scholarly journals Comparison of Effects of 3 and 7% Hypertonic Saline Nebulization on Lung Function in Children with Cystic Fibrosis: A Double-Blind Randomized, Controlled Trial

2012 ◽  
Vol 58 (5) ◽  
pp. 375-381 ◽  
Author(s):  
S. Gupta ◽  
F. Ahmed ◽  
R. Lodha ◽  
Y. K. Gupta ◽  
S. K. Kabra
Keyword(s):  
Cystic Fibrosis ◽  
Randomized Controlled Trial ◽  
Lung Function ◽  
Hypertonic Saline ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals A multi-centre, randomized, controlled trial on coaching and telemonitoring in patients with cystic fibrosis: conneCT CF

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Stephanie Thee ◽  
Mirjam Stahl ◽  
Rainald Fischer ◽  
Sivagurunathan Sutharsan ◽  
Manfred Ballmann ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Randomized Controlled Trial ◽  
Lung Function ◽  
Hospital Admissions ◽  
Controlled Trial ◽  
Forced Expiratory Volume ◽  
Inhalation Therapy ◽  
Secondary Outcome ◽  
Randomized Controlled ◽  
Behavior Change Interventions

Abstract Background The extend of lung disease remains the most important prognostic factor for survival in patients with cystic fibrosis (CF), and lack of adherence is the main reason for treatment failure. Early detection of deterioration in lung function and optimising adherence are therefore crucial in CF care. We implement a randomized controlled trial to evaluate efficacy of telemonitoring of adherence, lung function, and health condition in combination with behavior change interventions using innovative digital technologies. Methods This is a multi-centre, randomized, controlled, non-blinded trial aiming to include 402 patients ≥ 12 years-of-age with CF. A standard-of-care arm is compared to an arm receiving objective, continuous monitoring of adherence to inhalation therapies, weekly home spirometry using electronic devices with data transmission to patients and caring physicians combined with video-conferencing, a self-management app and professional telephone coaching. The duration of the intervention phase is 18 months. The primary endpoint is time to the first protocol-defined pulmonary exacerbation. Secondary outcome measures include number of and time between pulmonary exacerbations, adherence to inhalation therapy, changes in forced expiratory volume in 1 s from baseline, number of hospital admissions, and changes in health-related quality of life. CF-associated medical treatment and care, and health care related costs will be assessed by explorative analysis in both arms. Discussion This study offers the opportunity to evaluate the effect of adherence interventions using telemedicine capable devices on adherence and lung health, possibly paving the way for implementation of telemedicine in routine care for patients with CF. Trial registration: This study has been registered with the German Clinical Trials Register (Identifier: DRKS00024642, date of registration 01 Mar 2021, URL: https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00024642).

Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial

2001 ◽  
Vol 26 (1) ◽  
pp. 67-71 ◽  
Author(s):  
S. A. Ahmadi-Abhari ◽  
S. Akhondzadeh ◽  
S. M. Assadi ◽  
O. L. Shabestari ◽  
Z. M. Farzanehgan ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Side Effects ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled
Sign in / Sign up

Export Citation Format

Share Document