scholarly journals Editor’s Highlight: Modifying Role of Endothelial Function Gene Variants on the Association of Long-Term PM2.5 Exposure With Blood DNA Methylation Age: The VA Normative Aging Study

2017 ◽  
Vol 158 (1) ◽  
pp. 116-126 ◽  
Author(s):  
Jamaji C. Nwanaji-Enwerem ◽  
Marie-Abele Bind ◽  
Lingzhen Dai ◽  
Youssef Oulhote ◽  
Elena Colicino ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Endothelial Function ◽  
Gene Variants ◽  
Normative Aging Study ◽  
Aging Study ◽  
Dna Methylation Age ◽  
Normative Aging ◽  
Pm2.5 Exposure

scholarly journals Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study

2016 ◽  
Vol 2 (2) ◽  
pp. dvw006 ◽  
Author(s):  
Jamaji C. Nwanaji-Enwerem ◽  
Elena Colicino ◽  
Letizia Trevisi ◽  
Itai Kloog ◽  
Allan C. Just ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Normative Aging Study ◽  
Aging Study ◽  
Dna Methylation Age ◽  
Normative Aging ◽  
Ambient Particle

scholarly journals Associations between long-term exposure to PM2.5 component species and blood DNA methylation age in the elderly: The VA normative aging study

2017 ◽  
Vol 102 ◽  
pp. 57-65 ◽  
Author(s):  
Jamaji C. Nwanaji-Enwerem ◽  
Lingzhen Dai ◽  
Elena Colicino ◽  
Youssef Oulhote ◽  
Qian Di ◽  
...  
Keyword(s):  
Dna Methylation ◽  
The Elderly ◽  
Normative Aging Study ◽  
Aging Study ◽  
Dna Methylation Age ◽  
Normative Aging

scholarly journals Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study

2020 ◽  
Author(s):  
Jamaji C Nwanaji-Enwerem ◽  
Elena Colicino ◽  
Xu Gao ◽  
Cuicui Wang ◽  
Pantel Vokonas ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Vitamin B6 ◽  
Regression Models ◽  
Biological Aging ◽  
Kernel Machine ◽  
Normative Aging Study ◽  
Kernel Machine Regression ◽  
Aging Study ◽  
Dna Methylation Age ◽  
Normative Aging

Abstract One-carbon metabolism is an important contributor to aging-related diseases; nevertheless, relationships of one-carbon metabolites with novel DNA methylation-based measures of biological aging remain poorly characterized. We examined relationships of one-carbon metabolites with 3 DNA methylation-based measures of biological aging: DNAmAge, GrimAge, and PhenoAge. We measured plasma levels of 4 common one-carbon metabolites (vitamin B6, vitamin B12, folate, and homocysteine) in 715 VA Normative Aging Study participants with at least 1 visit between 1999 and 2008 (observations = 1153). DNA methylation age metrics were calculated using the HumanMethylation450 BeadChip. We utilized Bayesian Kernel Machine Regression models adjusted for chronological age, lifestyle factors, age-related diseases, and study visits to determine metabolites important to the aging outcomes. Bayesian Kernel Machine Regression models allowed for the estimation of the relationships of single metabolites and the cumulative metabolite mixture with methylation age. Log vitamin B6 was selected as important to PhenoAge (β = −1.62 years, 95% CI: −2.28, −0.96). Log folate was selected as important to GrimAge (β = 0.75 years, 95% CI: 0.41, 1.09) and PhenoAge (β = 1.62 years, 95% CI: 0.95, 2.29). Compared to a model where each metabolite in the mixture is set to its 50th percentile, the log cumulative mixture with each metabolite at its 30th (β = −0.13 years, 95% CI: −0.26, −0.005) and 40th percentile (β = −0.06 years, 95% CI: −0.11, −0.005) was associated with decreased GrimAge. Our results provide novel characterizations of the relationships between one-carbon metabolites and DNA methylation age in a human population study. Further research is required to confirm these findings and establish their generalizability.

scholarly journals Epigenome-wide DNA Methylation in Leukocyte and Toenail Metals: the Normative Aging Study

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Cuicui Wang ◽  
Anna Kosheleva ◽  
Yaguang Wei ◽  
Brent A. Coull ◽  
David Sparrow ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging

Short-Term Exposure to Ambient Particulate Elements and Epigenome-Wide DNA Methylation in Older Men: The Normative Aging Study

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Cuicui Wang ◽  
Andrea Baccarelli ◽  
Lifang Hou ◽  
Elena Colicino ◽  
Jincheng Shen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Older Men ◽  
Short Term ◽  
Normative Aging Study ◽  
Short Term Exposure ◽  
Aging Study ◽  
Normative Aging

scholarly journals Air Pollution and DNA Methylation: Interaction by Psychological Factors in the VA Normative Aging Study

2012 ◽  
Vol 176 (3) ◽  
pp. 224-232 ◽  
Author(s):  
Jaime Madrigano ◽  
Andrea Baccarelli ◽  
Murray A. Mittleman ◽  
David Sparrow ◽  
Avron Spiro ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Air Pollution ◽  
Psychological Factors ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging
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