scholarly journals Maternal Fenvalerate Exposure Induces Fetal Intrauterine Growth Restriction Through Disrupting Placental Thyroid Hormone Receptor Signaling

2017 ◽  
Vol 157 (2) ◽  
pp. 377-386 ◽  
Author(s):  
Bo Wang ◽  
Ji-Jie Liu ◽  
Yan Wang ◽  
Lin Fu ◽  
Ru Shen ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Intrauterine Growth Restriction ◽  
Thyroid Hormone Receptor ◽  
Growth Restriction ◽  
Receptor Signaling ◽  
Intrauterine Growth

Thyroid Hormone Receptor Signaling in Normal and Failing Heart

2009 ◽  
pp. 79-88
Author(s):  
Koichiro Kinugawa ◽  
Mark Y. Jeong ◽  
Michael R. Bristow ◽  
Carlin S. Long
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Signaling ◽  
Failing Heart

Human testicular orphan receptor 4 enhances thyroid hormone receptor signaling

2010 ◽  
Vol 222 (2) ◽  
pp. 347-356 ◽  
Author(s):  
Ya-Hui Huang ◽  
Chen-Hsin Liao ◽  
Ruey-Nan Chen ◽  
Chia-Jung Liao ◽  
Kwang-Huei Lin
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Orphan Receptor ◽  
Receptor Signaling

Abnormal thyroid hormone receptor signaling in osteoarthritic osteoblasts regulates microangiogenesis in subchondral bone

Life Sciences ◽  
2019 ◽  
Vol 239 ◽  
pp. 116975 ◽  
Author(s):  
Lei Li ◽  
Meng Li ◽  
Yiqun Pang ◽  
Jun Wang ◽  
Yunpeng Wan ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Subchondral Bone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Signaling

scholarly journals MCT8 expression in human fetal cerebral cortex is reduced in severe intrauterine growth restriction

2013 ◽  
Vol 220 (2) ◽  
pp. 85-95 ◽  
Author(s):  
Shiao Y Chan ◽  
Laura A Hancox ◽  
Azucena Martín-Santos ◽  
Laurence S Loubière ◽  
Merlin N M Walter ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Thyroid Hormone ◽  
Intrauterine Growth Restriction ◽  
Occipital Cortex ◽  
Growth Restriction ◽  
Receptor Expression ◽  
Cortical Plate ◽  
Human Fetuses ◽  
Intrauterine Growth ◽  
Significant Difference

The importance of the thyroid hormone (TH) transporter, monocarboxylate transporter 8 (MCT8), to human neurodevelopment is highlighted by findings of severe global neurological impairment in subjects withMCT8(SLC16A2) mutations. Intrauterine growth restriction (IUGR), usually due to uteroplacental failure, is associated with milder neurodevelopmental deficits, which have been partly attributed to dysregulated TH actionin uterosecondary to reduced circulating fetal TH concentrations and decreased cerebral thyroid hormone receptor expression. We postulate that altered MCT8 expression is implicated in this pathophysiology; therefore, in this study, we sought to quantify changes in cortical MCT8 expression with IUGR. First, MCT8 immunohistochemistry was performed on occipital and parietal cerebral cortex sections obtained from appropriately grown for gestational age (AGA) human fetuses between 19 weeks of gestation and term. Secondly, MCT8 immunostaining in the occipital cortex of stillborn IUGR human fetuses at 24–28 weeks of gestation was objectively compared with that in the occipital cortex of gestationally matched AGA fetuses. Fetuses demonstrated widespread MCT8 expression in neurons within the cortical plate and subplate, in the ventricular and subventricular zones, in the epithelium of the choroid plexus and ependyma, and in microvessel wall. When complicated by IUGR, fetuses showed a significant fivefold reduction in the percentage area of cortical plate immunostained for MCT8 compared with AGA fetuses (P<0.05), but there was no significant difference in the proportion of subplate microvessels immunostained. Cortical MCT8 expression was negatively correlated with the severity of IUGR indicated by the brain:liver weight ratios (r2=0.28;P<0.05) at post-mortem. Our results support the hypothesis that a reduction in MCT8 expression in the IUGR fetal brain could further compromise TH-dependent brain development.

scholarly journals Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction

Placenta ◽  
2010 ◽  
Vol 31 (4) ◽  
pp. 295-304 ◽  
Author(s):  
L.S. Loubière ◽  
E. Vasilopoulou ◽  
J.N. Bulmer ◽  
P.M. Taylor ◽  
B. Stieger ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Human Placenta ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth
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