scholarly journals Teratogenic effects of in utero exposure to di-(2-ethylhexyl)-phthalate (DEHP) in B6:129S4 mice

2017 ◽  
pp. kfx019
Author(s):  
Erica Ungewitter ◽  
Emmi Rotgers ◽  
Tanika Bantukul ◽  
Yasuhiko Kawakami ◽  
Grace E. Kissling ◽  
...  
Keyword(s):  
In Utero ◽  
In Utero Exposure ◽  
Teratogenic Effects ◽  
Ethylhexyl Phthalate

scholarly journals In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy.

2003 ◽  
Vol 111 (14) ◽  
pp. 1783-1785 ◽  
Author(s):  
Giuseppe Latini ◽  
Claudio De Felice ◽  
Giuseppe Presta ◽  
Antonio Del Vecchio ◽  
Irma Paris ◽  
...  
Keyword(s):  
In Utero ◽  
In Utero Exposure ◽  
Human Pregnancy ◽  
Ethylhexyl Phthalate

Effect of in utero exposure to di-(2-ethylhexyl)phthalate: Distribution in the rat fetus and testosterone production by rat fetal testis in culture

2006 ◽  
Vol 44 (12) ◽  
pp. 2064-2069 ◽  
Author(s):  
Thomas Stroheker ◽  
Jean-François Regnier ◽  
Julie Lassurguere ◽  
Marie-Christine Chagnon
Keyword(s):  
In Utero ◽  
In Utero Exposure ◽  
Rat Fetus ◽  
Fetal Testis ◽  
Testosterone Production ◽  
Ethylhexyl Phthalate

scholarly journals In Utero Exposure to Di-(2-ethylhexyl) Phthalate Exerts Both Short-Term and Long-Lasting Suppressive Effects on Testosterone Production in the Rat1

2008 ◽  
Vol 78 (6) ◽  
pp. 1018-1028 ◽  
Author(s):  
Martine Culty ◽  
Raphael Thuillier ◽  
Wenping Li ◽  
Yan Wang ◽  
Daniel B. Martinez-Arguelles ◽  
...  
Keyword(s):  
In Utero ◽  
In Utero Exposure ◽  
Short Term ◽  
Testosterone Production ◽  
Ethylhexyl Phthalate

scholarly journals In Utero Exposure to the Antiandrogen Di-(2-Ethylhexyl) Phthalate Decreases Adrenal Aldosterone Production in the Adult Rat1

2011 ◽  
Vol 85 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Daniel B. Martinez-Arguelles ◽  
Theodore Guichard ◽  
Martine Culty ◽  
Barry R. Zirkin ◽  
Vassilios Papadopoulos
Keyword(s):  
In Utero ◽  
In Utero Exposure ◽  
Aldosterone Production ◽  
Ethylhexyl Phthalate

scholarly journals In Utero Exposure to the Endocrine Disruptor Di-(2-Ethylhexyl) Phthalate Induces Long-Term Changes in Gene Expression in the Adult Male Adrenal Gland

Endocrinology ◽  
2014 ◽  
Vol 155 (5) ◽  
pp. 1667-1678 ◽  
Author(s):  
D.B. Martinez-Arguelles ◽  
E. Campioli ◽  
C. Lienhart ◽  
J. Fan ◽  
M. Culty ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Analysis ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Gene Expression Analysis ◽  
In Utero ◽  
In Utero Exposure ◽  
Long Term Effects ◽  
Ethylhexyl Phthalate ◽  
Dehp Exposure

The plasticizer di-(2-ethylhexyl) phthalate (DEHP) is used to add flexibility to polyvinylchloride polymers and as a component of numerous consumer and medical products. DEHP and its metabolites have been detected in amniotic fluid and umbilical cord blood, suggesting fetal exposure. In the present study, we used an in utero exposure model in which pregnant rat dams were exposed to 1- to 300-mg DEHP/kg·d from gestational day 14 until birth. We previously reported that this window of exposure to environmentally relevant doses of DEHP resulted in reduced levels of serum testosterone and aldosterone in adult male offspring and that the effects on aldosterone were sustained in elderly rats and resulted in decreased blood pressure. Here, we characterized the long-term effects of in utero DEHP exposure by performing global gene expression analysis of prepubertal (postnatal d 21) and adult (postnatal d 60) adrenal glands. We found that the peroxisome proliferator-activated receptor and lipid metabolism pathways were affected by DEHP exposure. Expression of 2 other DEHP targets, hormone-sensitive lipase and phosphoenolpyruvate carboxykinase 1 (Pck1), correlated with reduced aldosterone levels and may account for the inhibitory effect of DEHP on adrenal steroid formation. The angiotensin II and potassium pathways were up-regulated in response to DEHP. In addition, the potassium intermediate/small conductance calcium-activated channel Kcnn2 and 2-pore-domain potassium channel Knck5 were identified as DEHP targets. Based on this gene expression analysis, we measured fatty acid-binding protein 4 and phosphoenolpyruvate carboxykinase 1 in sera from control and DEHP-exposed rats and identified both proteins as putative serum biomarkers of in utero DEHP exposure. These results shed light on molecular targets that mediate DEHP long-term effects and, in doing so, provide means by which to assess past DEHP exposure.

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