scholarly journals Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects Are Diminished in Adrenalectomized Rats

2016 ◽  
Vol 150 (2) ◽  
pp. 312-322 ◽  
Author(s):  
Desinia B. Miller ◽  
Samantha J. Snow ◽  
Mette C. Schladweiler ◽  
Judy E. Richards ◽  
Andrew J. Ghio ◽  
...  
Keyword(s):  
Metabolic Effects ◽  
Adrenalectomized Rats

Possible involvement of glucocorticoids in the reduction of serum insulin levels by interleukin-1 in the rat

1992 ◽  
Vol 132 (3) ◽  
pp. 419-423 ◽  
Author(s):  
H. Shimizu ◽  
Y. Uehara ◽  
Y. Tanaka ◽  
Y. Shimomura ◽  
I. Kobayashi
Keyword(s):  
Plasma Glucose ◽  
Serum Insulin ◽  
Protective Action ◽  
Interleukin 1 ◽  
Inflammatory Cells ◽  
Metabolic Effects ◽  
Immunoreactive Insulin ◽  
Glucose Levels ◽  
Adrenalectomized Rats ◽  
Intact Rats

ABSTRACT Evidence is accumulating that adrenal steroids may be involved in the metabolic effects of cytokines. We evaluated the possible involvement of glucocorticoids in the inhibition of pancreatic insulin secretion by interleukin-1β (IL-1β), one of the cytokines produced by inflammatory cells. In the first group of experiments, adrenalectomized rats showed a significant reduction in basal and glucose (0·5 g/kg, i.v.)-stimulated immunoreactive insulin (IRI) levels after injection of IL-1β (1·0 μg/kg), but intact rats did not. Pretreatment with IL-1β increased plasma glucose levels 2 and 15 min after an i.v. bolus of glucose in adrenalectomized rats. In the second group of experiments, dexamethasone supplement (0·1 mg/kg) given to adrenalectomized rats cancelled the reduction in plasma glucose levels by IL-1β, and rats treated with 1·0 mg dexamethasone/kg showed a significant increase in basal IRI levels and enhanced serum IRI levels after IL-1β injection. However, 1·0 mg deoxycorticosterone/kg given daily for 7 days failed to cancel the effect of IL-1β on the reduction of serum IRI levels, although it attenuated the weight loss after adrenalectomy. The data suggested that withdrawal of glucocorticoids after adrenalectomy potentiates the effect of IL-1β on the reduction of serum IRI levels. Glucocorticoids may have a protective action against the reduction of serum IRI levels by IL-1β. Journal of Endocrinology (1992) 132, 419–423

A NOTE ON METABOLIC EFFECTS OF HYPOTHERMIA IN ADRENALECTOMIZED RATS

1963 ◽  
Vol 41 (1) ◽  
pp. 2038-2041
Author(s):  
D. M. McComiskey ◽  
J. R. Beaton
Keyword(s):  
Metabolic Effects ◽  
Adrenalectomized Rats

Null

Distribution of newly formed hepatic glycogen in adrenalectomized rats as observed by radioautography after injection of 3H-galactose

1984 ◽  
Vol 42 ◽  
pp. 228-229
Author(s):  
J. E. Michaels ◽  
J. T. Hung ◽  
E. L. Cardell ◽  
R. R. Cardell
Keyword(s):  
Glycogen Synthesis ◽  
Hepatic Glycogen ◽  
Electron Microscopic ◽  
Routine Procedures ◽  
Silver Grains ◽  
Synthetic Glucocorticoid ◽  
Adrenalectomized Rats

In order to study early events of glycogen synthesis, we have used adrenalectomized (ADX) rats fasted overnight and injected with the synthetic glucocorticoid dexamethasone (DEX) to stimulate glycogen synthesis. Rats were given DEX 0-5 hr prior to sacrifice and injected with 2 mCi 3H-galactose 1 hr prior to sacrifice. Liver was prepared for light (LM) and electron microscopic (EM) radioautography by routine procedures.The concentration of silver grains over hepatic cytoplasm was measured in LM radioautographs using a Zeiss Videoplan. The hepatocytes were categorized as unlabeled if no silver grains (gr) were present, lightly labeled (<10gr/100 μm2 cytoplasm) or intensely labeled (>10 gr/1002 μm cytoplasm). Although very few hepatocytes showed heavy labeling after 1 hr treatment with DEX, by 2 hr after DEX treatment 8% of the cells distributed throughout the lobule were intensely labeled.

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