scholarly journals Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?

2015 ◽  
Vol 149 (1) ◽  
pp. 237-250 ◽  
Author(s):  
Jason R. Slizgi ◽  
Yang Lu ◽  
Kenneth R. Brouwer ◽  
Robert L. St. Claire ◽  
Kimberly M. Freeman ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Contributing Factors ◽  
Hepatic Bile ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Bile Acid Transporters

scholarly journals Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

Metabolites ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 282
Author(s):  
Cristina Gómez ◽  
Simon Stücheli ◽  
Denise V. Kratschmar ◽  
Jamal Bouitbir ◽  
Alex Odermatt
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Bile Acids ◽  
Liver Tissue ◽  
Bioactive Molecules ◽  
Rodent Species ◽  
Drug Induced ◽  
Tissue Samples ◽  
Drug Induced Liver Injury ◽  
Bile Acid Profiles

Bile acids control lipid homeostasis by regulating uptake from food and excretion. Additionally, bile acids are bioactive molecules acting through receptors and modulating various physiological processes. Impaired bile acid homeostasis is associated with several diseases and drug-induced liver injury. Individual bile acids may serve as disease and drug toxicity biomarkers, with a great demand for improved bile acid quantification methods. We developed, optimized, and validated an LC-MS/MS method for quantification of 36 bile acids in serum, plasma, and liver tissue samples. The simultaneous quantification of important free and taurine- and glycine-conjugated bile acids of human and rodent species has been achieved using a simple workflow. The method was applied to a mouse model of statin-induced myotoxicity to assess a possible role of bile acids. Treatment of mice for three weeks with 5, 10, and 25 mg/kg/d simvastatin, causing adverse skeletal muscle effects, did not alter plasma and liver tissue bile acid profiles, indicating that bile acids are not involved in statin-induced myotoxicity. In conclusion, the established LC-MS/MS method enables uncomplicated sample preparation and quantification of key bile acids in serum, plasma, and liver tissue of human and rodent species to facilitate future studies of disease mechanisms and drug-induced liver injury.

scholarly journals Fasiglifam (TAK-875) alters bile acid homeostasis in rats and dogs: a potential cause of drug induced liver injury

2017 ◽  
pp. kfx018 ◽  
Author(s):  
Francis S. Wolenski ◽  
Andy Z. X. Zhu ◽  
Mike Johnson ◽  
Shaoxia Yu ◽  
Yuu Moriya ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats

2013 ◽  
Vol 268 (1) ◽  
pp. 79-89 ◽  
Author(s):  
Makoto Yamazaki ◽  
Manami Miyake ◽  
Hiroko Sato ◽  
Naoya Masutomi ◽  
Naohisa Tsutsui ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury

Medicine ◽  
2019 ◽  
Vol 98 (31) ◽  
pp. e16717 ◽  
Author(s):  
Zhenhua Ma ◽  
Xiaomei Wang ◽  
Peiyuan Yin ◽  
Ruihong Wu ◽  
Lina Zhou ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Novel Biomarkers

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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