scholarly journals Assessment of Temporal Dose-Toxicity Relationship of Fumed Silica Nanoparticle in Human Lung A549 Cells by Conventional Cytotoxicity and 1H-NMR-Based Extracellular Metabonomic Assays

2014 ◽  
Vol 138 (2) ◽  
pp. 354-364 ◽  
Author(s):  
Adeel Irfan ◽  
Michael Cauchi ◽  
William Edmands ◽  
Nigel J. Gooderham ◽  
James Njuguna ◽  
...  
Keyword(s):  
1H Nmr ◽  
Fumed Silica ◽  
Human Lung ◽  
A549 Cells ◽  
Silica Nanoparticle ◽  
Relationship Of ◽  
Toxicity Relationship

scholarly journals Exposure‐toxicity relationship of cabozantinib in patients with renal cell cancer and salivary gland cancer

2021 ◽  
Author(s):  
Stefanie D. Krens ◽  
Wim Boxtel ◽  
Maike J. M. Uijen ◽  
Frank G. A. Jansman ◽  
Ingrid M. E. Desar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Renal Cell Cancer ◽  
Renal Cell ◽  
Cell Cancer ◽  
Salivary Gland Cancer ◽  
Relationship Of ◽  
Toxicity Relationship

scholarly journals Comparative Toxic Effects of Manufactured Nanoparticles and Atmospheric Particulate Matter in Human Lung Epithelial Cells

2020 ◽  
Vol 18 (1) ◽  
pp. 22
Author(s):  
Yun Wu ◽  
Mei Wang ◽  
Shaojuan Luo ◽  
Yunfeng Gu ◽  
Dongyang Nie ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Human Lung ◽  
A549 Cells ◽  
Lung Epithelial Cells ◽  
Atmospheric Particulate Matter ◽  
Toxic Effects ◽  
Ros Generation ◽  
Atmospheric Particulate ◽  
Significant Difference ◽  
Lung Epithelial

Although nanoparticles (NPs) have been used as simplified atmospheric particulate matter (PM) models, little experimental evidence is available to support such simulations. In this study, we comparatively assessed the toxic effects of PM and typical NPs (four carbonaceous NPs with different morphologies, metal NPs of Fe, Al, and Ti, as well as SiO2 NPs) on human lung epithelial A549 cells. The EC50 value of PM evaluated by cell viability assay was 148.7 μg/mL, closest to that of SiO2 NPs, between the values of carbonaceous NPs and metal NPs. All particles caused varying degrees of reactive oxygen species (ROS) generation and adenosine triphosphate (ATP) suppression. TiO2 NPs showed similar performance with PM in inducing ROS production (p < 0.05). Small variations between two carbonaceous NPs (graphene oxides and graphenes) and PM were also observed at 50 μg/mL. Similarly, there was no significant difference in ATP inhibition between carbonaceous NPs and PM, while markedly different effects were caused by SiO2 NP and TiO2 NP exposure. Our results indicated that carbonaceous NPs could be served as potential surrogates for urban PM. The identification of PM model may help us further explore the specific roles and mechanisms of various components in PM.

Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells

2017 ◽  
Vol 494 (3-4) ◽  
pp. 641-647 ◽  
Author(s):  
Yasukazu Takanezawa ◽  
Ryosuke Nakamura ◽  
Yuka Sone ◽  
Shimpei Uraguchi ◽  
Keisuke Kobayashi ◽  
...  
Keyword(s):  
Human Lung ◽  
A549 Cells

Enhancing Effect of Poly(amino acid)s on Albumin Uptake in Human Lung Epithelial A549 Cells

2013 ◽  
Vol 28 (6) ◽  
pp. 497-503 ◽  
Author(s):  
Ryoko Yumoto ◽  
Sayuri Suzuka ◽  
Saori Nishimoto ◽  
Junya Nagai ◽  
Mikihisa Takano
Keyword(s):  
Amino Acid ◽  
Human Lung ◽  
A549 Cells ◽  
Enhancing Effect ◽  
Lung Epithelial
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