scholarly journals High Risk of Embryo-Fetal Toxicity: Placental Transfer of T-2 Toxin and Its Major Metabolite HT-2 Toxin in BeWo Cells

2013 ◽  
Vol 137 (1) ◽  
pp. 168-178 ◽  
Author(s):  
Xu Wang ◽  
Weiwei Wang ◽  
Guyue Cheng ◽  
Lingli Huang ◽  
Dongmei Chen ◽  
...  
Keyword(s):  
High Risk ◽  
Placental Transfer ◽  
Major Metabolite ◽  
Bewo Cells ◽  
Fetal Toxicity

PDGFRα monoclonal antibody: Assessment of embryo-fetal toxicity and time-dependent placental transfer of a murine surrogate antibody of olaratumab in mice

2018 ◽  
Vol 110 (18) ◽  
pp. 1358-1371 ◽  
Author(s):  
Debra Luffer-Atlas ◽  
Vijayapal R. Reddy ◽  
Kim G. Hilbish ◽  
Curtis E. Grace ◽  
William J Breslin
Keyword(s):  
Monoclonal Antibody ◽  
Placental Transfer ◽  
Time Dependent ◽  
Fetal Toxicity

Placental transfer and biological effect of zearalenone on BeWo cells: ABC transporter implication and regulation

2008 ◽  
Vol 180 ◽  
pp. S56
Author(s):  
Caroline Prouillac ◽  
Bernadette Videmann ◽  
Michelle Mazallon ◽  
Jonathan Tep ◽  
Sylvaine Lecoeur
Keyword(s):  
Abc Transporter ◽  
Biological Effect ◽  
Placental Transfer ◽  
Bewo Cells

Effect of oxygen concentrations on sodium iodide symporter expression and iodide uptake and hCG expression in human choriocarcinoma BeWo cells

2011 ◽  
Vol 300 (6) ◽  
pp. E1085-E1091 ◽  
Author(s):  
Huika Li ◽  
Kelly Landers ◽  
Jatin Patel ◽  
Kerry Richard ◽  
Robin H. Mortimer
Keyword(s):  
Sodium Iodide ◽  
Placental Transfer ◽  
First Trimester ◽  
Iron Chelator ◽  
Sodium Iodide Symporter ◽  
Iodide Uptake ◽  
Oxygen Levels ◽  
Bewo Cells ◽  
Effect Of Oxygen ◽  
The Impact

Normal human fetal development requires an adequate supply of thyroid hormone from conception. Until about 16 wk gestation this is supplied entirely by placental transfer of maternal hormone. Subsequently, the fetal thyroid synthesizes thyroid hormones, requiring a supply of maternal iodide. Trophoblast iodide transfer is mediated by the apical sodium iodide symporter (NIS). Placental oxygen levels are low in early pregnancy (∼1%), rising with placental vascularisation to a plateau of ∼8% at about 16 wk. Although the impact of these changing oxygen levels on placental implantation is well recognized, effects on trophoblast materno-fetal exchange are less understood. We investigated expression of the NIS regulator hCG, NIS mRNA expression, and I125 uptake in choriocarcinoma BeWo cells (a model of the trophoblast) cultured in 1 and 8% oxygen and in room air (21% oxygen). Expression of NIS and hCG mRNA and protein was low at 1% oxygen but rose significantly at 8 and at 21%. This was reflected in significant increases in I125 uptake. Desferrioxamine, an iron chelator and hypoxia mimic, decreased NIS and hCG expression and I125 uptake in BeWo cells. NIS expression and I125 uptake in cells grown at 1% oxygen were not increased by addition of hCG (2,500 IU/l). We infer that placental NIS mRNA and protein expression are regulated by oxygen, rising with vascularization of the placenta in the late first trimester, a time when fetal iodide requirements are increasing.

scholarly journals Maternal Antibodies to Pneumolysin but Not to Pneumococcal Surface Protein A Delay Early Pneumococcal Carriage in High-Risk Papua New Guinean Infants

2009 ◽  
Vol 16 (11) ◽  
pp. 1633-1638 ◽  
Author(s):  
Jacinta P. Francis ◽  
Peter C. Richmond ◽  
William S. Pomat ◽  
Audrey Michael ◽  
Helen Keno ◽  
...  
Keyword(s):  
High Risk ◽  
Placental Transfer ◽  
Protein A ◽  
Surface Protein ◽  
Upper Respiratory Tract ◽  
Specific Antibodies ◽  
Pneumococcal Carriage ◽  
Pneumococcal Surface Protein A ◽  
Antibody Titers ◽  
High Risk Infants

ABSTRACT Immunization of pregnant women can be an efficient strategy to induce early protection in infants in developing countries. Pneumococcal protein-based vaccines may have the capacity to induce pneumococcal serotype-independent protection. To understand the potential of maternal pneumococcal protein-specific antibodies in infants in high-risk areas, we studied the placental transfer of naturally acquired antibodies to pneumolysin (Ply) and pneumococcal surface protein A family 1 and 2 (PspA1 and PspA2) in relation to onset of pneumococcal nasopharyngeal carriage in infants in Papua New Guinea (PNG). In this study, 76% of the infants carried Streptococcus pneumoniae in the upper respiratory tract within the first month of life, at a median age of 19 days. Maternal and cord blood antibody titers to Ply (ρ = 0.824, P < 0.001), PspA1 (ρ = 0.746, P < 0.001), and PspA2 (ρ = 0.631, P < 0.001) were strongly correlated. Maternal pneumococcal carriage (hazard ratio [HR], 2.60; 95% confidence interval [CI], 1.25 to 5.39) and younger maternal age (HR, 0.74; 95% CI, 0.54 to 1.00) were independent risk factors for early carriage, while higher cord Ply-specific antibody titers predicted a significantly delayed onset (HR, 0.71; 95% CI, 0.52 to 1.00) and cord PspA1-specific antibodies a significantly younger onset of carriage in PNG infants (HR, 1.57; 95% CI, 1.03 to 2.40). Maternal vaccination with a pneumococcal protein-based vaccine should be considered as a strategy to protect high-risk infants against pneumococcal disease by reducing carriage risks in both mothers and infants.

Ultrastructure of Choriocarcinoma in Vitro

1969 ◽  
Vol 27 ◽  
pp. 362-363
Author(s):  
John C. Garancis ◽  
R. A. Pattillo
Keyword(s):  
Cell Line ◽  
Physiological Function ◽  
Cell System ◽  
Bewo Cell ◽  
Bewo Cells ◽  
Gestational Choriocarcinoma ◽  
Bewo Cell Line

Growth of cell system (BeWo-cell line) derived from human gestational choriocarcinoma has been established and continuously maintained in-vitro. Furthermore, it is evident from the previous studies that this cell line has retained the physiological function of the placental trophoblasts, namely the synthesis of human chorionic gonadotrophil(HCG).The BeWo cells were relatively small and possessed single nuclei, thus indicating that this cell line consists exclusively of cytotrophoblasts. In some instances cells appeared widely separated and their lateral surfaces were provided with numerous microvilli (Fig.1).

A Community Based High Risk Register for Hearing Loss

1982 ◽  
Vol 47 (4) ◽  
pp. 373-375 ◽  
Author(s):  
James L. Fitch ◽  
Thomas F. Williams ◽  
Josephine E. Etienne
Keyword(s):  
Hearing Loss ◽  
System Identification ◽  
High Risk ◽  
Language Learning ◽  
Education Program ◽  
Communication System ◽  
Auditory Signal ◽  
Early Age ◽  
Community Based ◽  
Children With Hearing Loss

The critical need to identify children with hearing loss and provide treatment at the earliest possible age has become increasingly apparent in recent years (Northern & Downs, 1978). Reduction of the auditory signal during the critical language-learning period can severely limit the child's potential for developing a complete, effective communication system. Identification and treatment of children having handicapping conditions at an early age has gained impetus through the Handicapped Children's Early Education Program (HCEEP) projects funded by the Bureau of Education for the Handicapped (BEH).

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