scholarly journals Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

2013 ◽  
Vol 136 (1) ◽  
pp. 97-106 ◽  
Author(s):  
Mathieu Vinken ◽  
Brigitte Landesmann ◽  
Marina Goumenou ◽  
Stefanie Vinken ◽  
Imran Shah ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Adverse Outcome ◽  
Adverse Outcome Pathway ◽  
Bile Salt Export Pump ◽  
Cholestatic Liver Injury

Omics-based in vitro verification of an adverse outcome pathway of cholestatic liver injury

2017 ◽  
Vol 280 ◽  
pp. S254
Author(s):  
Robim M. Rodrigues ◽  
Laxmikanth Kollipara ◽  
Umesh Chaudhari ◽  
Agapios Sachinidis ◽  
René P. Zahedi ◽  
...  
Keyword(s):  
Liver Injury ◽  
Adverse Outcome ◽  
Adverse Outcome Pathway ◽  
Cholestatic Liver Injury

scholarly journals Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury

2020 ◽  
Vol 94 (4) ◽  
pp. 1151-1172 ◽  
Author(s):  
Eva Gijbels ◽  
Vânia Vilas‐Boas ◽  
Pieter Annaert ◽  
Tamara Vanhaecke ◽  
Lindsey Devisscher ◽  
...  
Keyword(s):  
Liver Injury ◽  
Adverse Outcome ◽  
Adverse Outcome Pathway ◽  
Robustness Testing ◽  
Cholestatic Liver Injury

scholarly journals Cholestatic Drug Induced Liver Injury: A Function of Bile Salt Export Pump Inhibition and Farnesoid X Receptor Antagonism

2018 ◽  
Vol 4 (3) ◽  
pp. 265-279 ◽  
Author(s):  
Jonathan P. Jackson ◽  
Kimberly M. Freeman ◽  
Robert L. St. Claire ◽  
Chris B. Black ◽  
Kenneth R. Brouwer
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Farnesoid X Receptor ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Receptor Antagonism ◽  
Drug Induced Liver Injury

scholarly journals Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance

Hepatology ◽  
2021 ◽  
Author(s):  
Jelena Remetic ◽  
Ahmed Ghallab ◽  
Zaynab Hobloss ◽  
Lisa Brackhagen ◽  
Reham Hassan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump

scholarly journals Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

2018 ◽  
Vol 104 (5) ◽  
pp. 916-932 ◽  
Author(s):  
J. Gerry Kenna ◽  
Kunal S. Taskar ◽  
Christina Battista ◽  
David L. Bourdet ◽  
Kim L.R. Brouwer ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Liver Injury ◽  
Bile Salt ◽  
Injury Risk ◽  
Bile Salt Export Pump ◽  
Drug Discovery And Development

Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury

2013 ◽  
Vol 33 (9) ◽  
pp. 1378-1385 ◽  
Author(s):  
Eugenia Ulzurrun ◽  
Camilla Stephens ◽  
Esperanza Crespo ◽  
Francisco Ruiz-Cabello ◽  
Julia Ruiz-Nuñez ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Chemical Structures
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