scholarly journals In Vitro Exposure of Precision-Cut Lung Slices to 2-(4-Amino-3-Methylphenyl)-5-Fluorobenzothiazole Lysylamide Dihydrochloride (NSC 710305, Phortress) Increases Inflammatory Cytokine Content and Tissue Damage

2012 ◽  
Vol 131 (2) ◽  
pp. 470-479 ◽  
Author(s):  
Holger P. Behrsing ◽  
Michael J. Furniss ◽  
Myrtle Davis ◽  
Joseph E. Tomaszewski ◽  
Ralph E. Parchment
Keyword(s):  
Tissue Damage ◽  
Inflammatory Cytokine ◽  
In Vitro Exposure ◽  
Precision Cut Lung Slices

The effect of antidepressants on inflammatory markers in animal models of depression

2011 ◽  
Vol 26 (S2) ◽  
pp. 2091-2091
Author(s):  
A. Harkin ◽  
T.J. Connor
Keyword(s):  
Animal Models ◽  
Inflammatory Cytokines ◽  
Glial Cells ◽  
Inflammatory Cytokine ◽  
Animal Models Of Depression ◽  
In Vitro Exposure ◽  
Anti Inflammatory ◽  
Pro Inflammatory Cytokines

Considering the evidence that pro-inflammatory cytokines play a causal role in depressive illness, the ability of antidepressants to induce anti-inflammatory effects is a subject of considerable interest. In an in vivo context we observe that antidepressants that enhance noradrenaline availability are the most effective anti-inflammatory agents; a fact consistent with the established anti-inflammatory actions of noradrenaline. Specifically, we have observed that noradrenaline reuptake inhibitors (NRIs) inhibit microglial activation and inhibit expression of pro-inflammatory cytokines (IL-1beta and TNF-alpha), iNOS, and inflammatory chemokines (IP-10 and RANTES) in rat brain following a systemic inflammatory challenge. These in vivo anti-inflammatory actions of NRIs are mimicked by in vitro exposure of primary glial cells to noradrenaline, but not by in vitro exposure of glial cells to the drugs themselves. These data suggest that NRIs promote an anti-inflammatory environment in rat brain in vivo by increasing noradrenaline availability at glial cells. We have also observed that even in the absence of any overt inflammation, chronic treatment with the NRI reboxetine promotes an anti-inflammatory phenotype in the CNS characterised by reduced expression of pro-inflammatory cytokine IFN-gamma, and increased expression of the anti-inflammatory cytokine IL-10. Current experiments are focused on the activation of the inflammatory response system in animal models of depression secondary to inflammation. The models are used subsequently to assess the anti-inflammatory effects of antidepressants in vivo.

Alterations in the non-neuronal cholinergic system induced by in-vitro exposure to diazoxon in spleen mononuclear cells of Nile tilapia (O. niloticus)

2021 ◽  
Vol 108 ◽  
pp. 134-141
Author(s):  
G.A. Toledo-Ibarra ◽  
M.I. Girón-Pérez ◽  
C.E. Covantes-Rosales ◽  
G.H. Ventura-Ramón ◽  
G. Pérez-Sánchez ◽  
...  
Keyword(s):  
Cholinergic System ◽  
Nile Tilapia ◽  
Mononuclear Cells ◽  
In Vitro Exposure

scholarly journals Zearalenone alters the excitability of rat neuronal networks after acute in vitro exposure

2021 ◽  
Author(s):  
Veronika Bódi ◽  
Vivien Csikós ◽  
Tímea Májer ◽  
Attila Tóth ◽  
Árpád Dobolyi ◽  
...  
Keyword(s):  
Neuronal Networks ◽  
In Vitro Exposure

Excimer, Ho:YAG, and Q-switched Ho:YAG ablation of aorta: a comparison of temperatures and tissue damage in vitro

1993 ◽  
Vol 32 (4) ◽  
pp. 526 ◽  
Author(s):  
E. Duco Jansen ◽  
Tuong H. Le ◽  
Ashley J. Welch
Keyword(s):  
Tissue Damage

Azithromycin suppresses P. gingivalis LPS-induced pro-inflammatory cytokine and chemokine production by human gingival fibroblasts in vitro

2014 ◽  
Vol 19 (2) ◽  
pp. 221-227 ◽  
Author(s):  
C. J. Doyle ◽  
T. R. Fitzsimmons ◽  
C. Marchant ◽  
A. A. S. S. K. Dharmapatni ◽  
R. Hirsch ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Chemokine Production

scholarly journals Aberrant DNA methylation of imprinted loci in hepatocellular carcinoma and after in vitro exposure to common risk factors

2015 ◽  
Vol 7 (1) ◽  
pp. 15 ◽  
Author(s):  
Marie-Pierre Lambert ◽  
Pierre-Benoit Ancey ◽  
Davide Esposti ◽  
Marie-Pierre Cros ◽  
Athena Sklias ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
In Vitro Exposure ◽  
Common Risk Factors ◽  
Aberrant Dna Methylation
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