scholarly journals In Ovo Effects of Perfluorohexane Sulfonate and Perfluorohexanoate on Pipping Success, Development, mRNA Expression, and Thyroid Hormone Levels in Chicken Embryos

2012 ◽  
Vol 127 (1) ◽  
pp. 216-224 ◽  
Author(s):  
Cristina G. Cassone ◽  
Viengtha Vongphachan ◽  
Suzanne Chiu ◽  
Kim L. Williams ◽  
Robert J. Letcher ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Mrna Expression ◽  
In Ovo ◽  
Chicken Embryos ◽  
Hormone Levels ◽  
Thyroid Hormone Levels

Interaction of PCBs with Thyroid Hormone Levels and Time of Hatching in Chicken Embryos

2005 ◽  
Vol 1040 (1) ◽  
pp. 224-226 ◽  
Author(s):  
V. BECK ◽  
S A ROELENS ◽  
J MAERVOET ◽  
P SCHEPENS ◽  
V.M DARRAS
Keyword(s):  
Thyroid Hormone ◽  
Chicken Embryos ◽  
Hormone Levels ◽  
Thyroid Hormone Levels

scholarly journals TDCPP exposure affects the concentrations of thyroid hormones in zebrafish

2017 ◽  
Author(s):  
Jingxin Song
Keyword(s):  
Thyroid Hormone ◽  
Mrna Expression ◽  
Survival Rates ◽  
Mrna Levels ◽  
Expression Levels ◽  
Hormone Levels ◽  
Zebrafish Larvae ◽  
Thyroid Hormone Levels ◽  
Hpt Axis ◽  
Mrna Expression Levels

AbstractPrevious studies show that TDCPP may interrupt the thyroid endocrine system, however, the potential mechanisms involved in these processes were largely unknown. In this study, zebrafish embryos/larvae were exposed to TDCPP until 120 hpf, by which time most of the organs of the larvae have completed development. In this study, the effects of TDCPP on HPT axis were examined and the thyroid hormone levels were measured after TDCPP treatment. Zebrafish (Danio rerio) embryos were treated with a series concentration of TDCPP (10, 20, 40, 80, 160 and 320 μg/L) from 1 day post-fertilization (dpf) to 5 dpf. Exposure concentrations of TDCPP were determined based on the survival rates in each group. Total mRNA were isolated, first-strand cDNA were synthesis and qPCR were performed to detect the mRNA expression levels in hypothalamic-pituitary-thyroid (HPT) axis. The mRNA expression levels of genes involved in thyroid hormone homeostasis were increased in the TDCPP-treated larvae. The mRNA levels of genes involved in thyroid hormone synthesis were also increased in the embryos treated with TDCPP. Furthermore, exposure to TDCPP led to a dose-dependent effect on zebrafish development, including diminished hatching and survival rates, increased malformation. TDCPP treatment significantly reduced the T4 concentration in the 5 dpf zebrafish larvae, but increased the concentration of T3, suggesting the function of thyroid endocrine were interrupted in the TDCPP-exposed zebrafish. Taken together, these data indicated that TDCPP affected the thyroid hormone levels in the zebrafish larvae and could increased the mRNA expression levels of genes related to HPT axis, which further impaired the endocrine homeostasis and thyroid system.

Evaluation of Positive Inotropic Drug Effects on Thyroid Hormone Levels after Open Heart Surgery

2015 ◽  
Vol 16 (2) ◽  
pp. 78
Author(s):  
Umit Kervan ◽  
Anil Ozen ◽  
Utku Unal ◽  
Irfan Tasoglu ◽  
Mahmut Mustafa Ulas ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Thyroid Hormone ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Inotropic Drug ◽  
Hormone Levels ◽  
Inotropic Drugs ◽  
Positive Inotropic Drug ◽  
Thyroid Hormone Levels

<p><b>Objective:</b> The aim of this study was to examine the effects of positive inotropic drugs, including adrenaline, dopamine, and dobutamine on thyroid hormone levels following open heart surgery.</p><p><b>Methods:</b> We analyzed free thyroid hormones (FT3 and FT4) and thyroid-stimulating hormones (TSH) in 200 consecutive patients undergoing open heart surgery. Patients were divided into 5 groups according to the inotropic drug administration as follows: Group A (n = 46) received dopamine alone; Group B (n = 40), dopamine and dobutamine; Group C (n = 36), dopamine, dobutamine, and adrenaline; Group D (n = 32), adrenaline alone; and Group E (n = 46), placebo. Procedural factors affecting thyroid hormones were recorded and included cardiopulmonary bypass (CPB) time, cross-clamping time, degree of hypothermia, and the duration and doses of positive inotropic drugs. Blood samples for hormone assays were collected before initiation of inotropic drug therapy (baseline) and postoperatively at 24, 72, and 120 hours after drug therapy.</p><p><b>Results:</b> FT3, FT4, and TSH levels at baseline were similar in all groups. Although there was a trend showing very slight increases in thyroid hormone levels from baseline to the 24th, 72nd, and 120th postoperative hours after drug therapy, these changes were not significant, and there were also no significant differences between the groups. There was also no significant statistical difference in CPB time, cross-clamping time, degree of hypothermia, and duration and doses of positive inotropic drugs between groups.</p><p><b>Conclusion:</b> Although thyroid hormone levels were affected by positive inotropic drug usage after open heart surgery, this effect was not significant and thyroid hormone levels remained within normal ranges.</p>

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