scholarly journals Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model

2012 ◽  
Vol 126 (2) ◽  
pp. 578-588 ◽  
Author(s):  
Eric F. Lock ◽  
Nour Abdo ◽  
Ruili Huang ◽  
Menghang Xia ◽  
Oksana Kosyk ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
In Vitro Model ◽  
Population Based ◽  
Chemical Toxicity ◽  
Vitro Model

A high-throughput in vitro model of human embryo attachment

2012 ◽  
Vol 97 (4) ◽  
pp. 974-978 ◽  
Author(s):  
Huiting Ho ◽  
Harmeet Singh ◽  
Mohamad Aljofan ◽  
Guiying Nie
Keyword(s):  
High Throughput ◽  
Human Embryo ◽  
In Vitro Model ◽  
Vitro Model ◽  
Embryo Attachment

scholarly journals Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

2015 ◽  
Vol 123 (5) ◽  
pp. 458-466 ◽  
Author(s):  
Nour Abdo ◽  
Menghang Xia ◽  
Chad C. Brown ◽  
Oksana Kosyk ◽  
Ruili Huang ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Response Assessment ◽  
Population Based ◽  
1000 Genomes ◽  
Screening Study

scholarly journals Future Directions in the Treatment of Patients with Chronic Hepatitis C Virus Infection

1999 ◽  
Vol 13 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Robert G Gish
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
High Throughput Screening ◽  
In Vitro Model ◽  
Single Agent ◽  
Protein Translation ◽  
In Vitro Translation ◽  
Biotechnology Companies ◽  
Vitro Model

Hepatitis C virus (HCV) infects over 170 million people worldwide. While interferon is currently the most used single agent therapy, this drug may result in a sustained loss of virus from the blood in only up to 15% of patients; new options for treatment are needed. With the release of ribavirin in North America and Europe, a viral clearance rate or ‘cure’ may be attained in up to 40% of patients. Developing successful antiviral therapy that prevents or delays the development of cirrhosis, liver failure and liver cancer as well as decreasing the demand for liver transplantation are clearly identified goals. Unfortunately, there is no complete in vitro model of HCV replication or translation. Due to the lack of an animal or cell culture model of HCV infection, in vitro translation screening systems to identify inhibitors of HCV protein translation are being evaluated by a large number of biotechnology companies. With advancing computer technology, high throughput screening processes are now possible and can be joined to specific in vitro model testing systems. Along with examining some of the information known about HCV therapy and the HCV genome, the present review discusses potential targets for new therapies and identifies therapeutic agents that are nearing clinical application

scholarly journals Novel High-Throughput In Vitro Model for Identifying Hemodynamic-Induced Inflammatory Mediators of Cerebral Aneurysm Formation

Hypertension ◽  
2014 ◽  
Vol 64 (6) ◽  
pp. 1306-1313 ◽  
Author(s):  
Kamil W. Nowicki ◽  
Koji Hosaka ◽  
Yong He ◽  
Peter S. McFetridge ◽  
Edward W. Scott ◽  
...  
Keyword(s):  
Cerebral Aneurysm ◽  
High Throughput ◽  
Inflammatory Mediators ◽  
In Vitro Model ◽  
Aneurysm Formation ◽  
Vitro Model
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