scholarly journals Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714

2009 ◽  
Vol 108 (2) ◽  
pp. 492-500 ◽  
Author(s):  
Bo Feng ◽  
Jinghai J. Xu ◽  
Yi-An Bi ◽  
Rouchelle Mireles ◽  
Ralph Davidson ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Hepatic Transporters ◽  
Her2 Tyrosine Kinase Inhibitor

scholarly journals Studies on the Role of Metabolic Activation in Tyrosine Kinase Inhibitor–Dependent Hepatotoxicity: Induction of CYP3A4 Enhances the Cytotoxicity of Lapatinib in HepaRG Cells

2013 ◽  
Vol 42 (1) ◽  
pp. 162-171 ◽  
Author(s):  
Klarissa D. Hardy ◽  
Michelle D. Wahlin ◽  
Ioannis Papageorgiou ◽  
Jashvant D. Unadkat ◽  
Allan E. Rettie ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Metabolic Activation ◽  
Heparg Cells
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