scholarly journals Aryl Hydrocarbon Receptor Targets Pathways Extrinsic to Bone Marrow Cells to Enhance Neutrophil Recruitment during Influenza Virus Infection

2007 ◽  
Vol 102 (1) ◽  
pp. 89-99 ◽  
Author(s):  
Sabine Teske ◽  
Andrea A. Bohn ◽  
Jason P. Hogaboam ◽  
B. Paige Lawrence
Keyword(s):  
Bone Marrow ◽  
Influenza Virus ◽  
Virus Infection ◽  
Aryl Hydrocarbon Receptor ◽  
Bone Marrow Cells ◽  
Influenza Virus Infection ◽  
Neutrophil Recruitment ◽  
Aryl Hydrocarbon ◽  
Receptor Targets ◽  
Marrow Cells

scholarly journals Aryl Hydrocarbon Receptor Activation Reduces Dendritic Cell Function during Influenza Virus Infection

2010 ◽  
Vol 116 (2) ◽  
pp. 514-522 ◽  
Author(s):  
Guang-Bi Jin ◽  
Amanda J. Moore ◽  
Jennifer L. Head ◽  
Joshua J. Neumiller ◽  
B. Paige Lawrence
Keyword(s):  
Influenza Virus ◽  
Dendritic Cell ◽  
Virus Infection ◽  
Aryl Hydrocarbon Receptor ◽  
Cell Function ◽  
Influenza Virus Infection ◽  
Receptor Activation ◽  
Dendritic Cell Function ◽  
Aryl Hydrocarbon

CXCR2 Is Required for Neutrophil Recruitment to the Lung during Influenza Virus Infection, But Is Not Essential for Viral Clearance

2007 ◽  
Vol 20 (3) ◽  
pp. 369-378 ◽  
Author(s):  
Mark D. Wareing ◽  
Ashley L. Shea ◽  
Chandra A. Inglis ◽  
Peter B. Dias ◽  
Sally R. Sarawar
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Viral Clearance ◽  
Neutrophil Recruitment

scholarly journals Toll-like receptor-4: Renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis

2005 ◽  
Vol 68 (6) ◽  
pp. 2582-2587 ◽  
Author(s):  
Prashant S. Patole ◽  
Soren Schubert ◽  
Kirsten Hildinger ◽  
Sascha Khandoga ◽  
Andrej Khandoga ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Neutrophil Recruitment ◽  
Toll Like Receptor ◽  
Renal Cells ◽  
Toll Like Receptor 4 ◽  
Marrow Cells

Defects in T-cell–mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector–mediated gene transfer into repopulating hematopoietic cells

Blood ◽  
2003 ◽  
Vol 102 (9) ◽  
pp. 3108-3116 ◽  
Author(s):  
Ted S. Strom ◽  
Stephen J. Turner ◽  
Samita Andreansky ◽  
Haiyan Liu ◽  
Peter C. Doherty ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Influenza Virus ◽  
T Cell ◽  
Cell Response ◽  
Bone Marrow Cells ◽  
T Cell Response ◽  
Lymphoid Cells ◽  
Wiskott Aldrich Syndrome ◽  
Marrow Cells

AbstractThe Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by immune dysfunction, thrombocytopenia, and eczema. We used a murine model created by knockout of the WAS protein gene (WASP) to evaluate the potential of gene therapy for WAS. Lethally irradiated, male WASP— animals that received transplants of mixtures of wild type (WT) and WASP— bone marrow cells demonstrated enrichment of WT cells in the lymphoid and myeloid lineages with a progressive increase in the proportion of WT T-lymphoid and B-lymphoid cells. WASP— mice had a defective secondary T-cell response to influenza virus which was normalized in animals that received transplants of 35% or more WT cells. The WASP gene was inserted into WASP— bone marrow cells with a bicistronic oncoretroviral vector also encoding green fluorescent protein (GFP), followed by transplantation into irradiated male WASP— recipients. There was a selective advantage for gene-corrected cells in multiple lineages. Animals with higher proportions of GFP+ T cells showed normalization of their lymphocyte counts. Gene-corrected, blood T cells exhibited full and partial correction, respectively, of their defective proliferative and cytokine secretory responses to in vitro T-cell–receptor stimulation. The defective secondary T-cell response to influenza virus was also improved in gene-corrected animals.

scholarly journals Bone Marrow B Cell Apoptosis During In Vivo Influenza Virus Infection Requires TNF-α and Lymphotoxin-α

2002 ◽  
Vol 169 (11) ◽  
pp. 6193-6201 ◽  
Author(s):  
Lisa M. Sedger ◽  
Sam Hou ◽  
Sarah R. Osvath ◽  
Moira B. Glaccum ◽  
Jacques J. Peschon ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Influenza Virus ◽  
Virus Infection ◽  
B Cell ◽  
Cell Apoptosis ◽  
Influenza Virus Infection ◽  
Tnf Α ◽  
Lymphotoxin Α

scholarly journals Susceptibility of bone marrow-derived macrophages to influenza virus infection is dependent on macrophage phenotype

2015 ◽  
Vol 96 (10) ◽  
pp. 2951-2960 ◽  
Author(s):  
Gillian M. Campbell ◽  
Marlynne Q. Nicol ◽  
Ian Dransfield ◽  
Darren J. Shaw ◽  
Anthony A. Nash ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
Macrophage Phenotype
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