scholarly journals Internalization of Libby Amphibole Asbestos and Induction of Oxidative Stress in Murine Macrophages

2007 ◽  
Vol 99 (1) ◽  
pp. 277-288 ◽  
Author(s):  
D. J. Blake ◽  
C. M. Bolin ◽  
D. P. Cox ◽  
F. Cardozo-Pelaez ◽  
J. C. Pfau
Keyword(s):  
Oxidative Stress ◽  
Murine Macrophages ◽  
Amphibole Asbestos ◽  
Libby Amphibole

Exposure-response modeling of non-cancer effects in humans exposed to Libby Amphibole Asbestos; update

2015 ◽  
Vol 73 (3) ◽  
pp. 780-789 ◽  
Author(s):  
Robert Benson ◽  
David Berry ◽  
James Lockey ◽  
William Brattin ◽  
Timothy Hilbert ◽  
...  
Keyword(s):  
Exposure Response ◽  
Amphibole Asbestos ◽  
Libby Amphibole ◽  
Response Modeling

Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2

2013 ◽  
Vol 1830 (10) ◽  
pp. 4650-4659 ◽  
Author(s):  
Guadalupe Martel-Gallegos ◽  
Griselda Casas-Pruneda ◽  
Filiberta Ortega-Ortega ◽  
Sergio Sánchez-Armass ◽  
Jesús Alberto Olivares-Reyes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
P2x7 Receptor ◽  
Receptor Stimulation ◽  
Murine Macrophages

Comparative health effects in mice of Libby amphibole asbestos and a fibrous amphibole from Arizona

2017 ◽  
Vol 334 ◽  
pp. 24-34 ◽  
Author(s):  
Jean C. Pfau ◽  
Brenda Buck ◽  
Rodney V. Metcalf ◽  
Zoie Kaupish ◽  
Caleb Stair ◽  
...  
Keyword(s):  
Health Effects ◽  
Amphibole Asbestos ◽  
Libby Amphibole

Influence of dietary fat on oxidative stress and inflammation in murine macrophages

Nutrition ◽  
2009 ◽  
Vol 25 (5) ◽  
pp. 548-554 ◽  
Author(s):  
Rocío de la Puerta ◽  
Ana Marquez-Martin ◽  
Angeles Fernandez-Arche ◽  
Valentina Ruiz-Gutierrez
Keyword(s):  
Oxidative Stress ◽  
Dietary Fat ◽  
Murine Macrophages

N-Acetyl-tryptophan glucoside (NATG) protects J774A.1 murine macrophages against gamma radiation-induced cell death by modulating oxidative stress

2018 ◽  
Vol 447 (1-2) ◽  
pp. 9-19 ◽  
Author(s):  
Poonam Malhotra ◽  
Ashutosh K. Gupta ◽  
Darshana Singh ◽  
Saurabh Mishra ◽  
Shravan K. Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Gamma Radiation ◽  
Murine Macrophages ◽  
Radiation Induced

Abstract 253: Di-n-butyl Phthalate: An Indoor Pollutant Induces Murine Macrophages Oxidative Stress and Inflammation, a Potential Atheropathogenesis Modulator

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Zahra Mazhar ◽  
Dhuha Alsayrafi ◽  
Tong Wu ◽  
Mahdi Garelnabi
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Tnf Alpha ◽  
Gene Expressions ◽  
Compensatory Response ◽  
Murine Macrophages ◽  
Atherosclerosis Progression ◽  
Indoor Pollutant ◽  
Human Cardiovascular System ◽  
Butyl Phthalate

Di-n-butyl phthalate (DBP) is used in air fresheners. It is a colorless oily compound which also used for manufacturing bendable plastics. DBP can cause low acute or chronic toxicity; however, the effect of DBP on humans in the form of air fresheners is not well studied. The effect of DBP on the human cardiovascular system has not been studied. Macrophages are involved in atherosclerosis progression and development; murine macrophages (RAW 264.7) were used for this study. The macrophages were treated with 10uM, 20uM and 50uM DBP for 6 hours, 12 hours and 24 hours. Genes involved in inflammation and antioxidant activity like TNF-a, MCP-1, VCAM-1, NF-kB, PON1, SOCS were analyzed after treatment. macrophages showed statistically significant increases in TNF-alpha expression (p≤ 0.05) after 24 hour treatment with DBP. The expression of NF-kB showed a significant increase in response to DBP treatment (p≤ 0.05) at 24 hours. MCP-1 and VCAM-1 gene expressions were also upregulated after exposure to DBP. Interestingly, catalase gene expression was upregulated in all treatments after 24 hours of exposure however PON-1 gene expression showed differential upregulation responses. Our data clearly suggest that DBP induces inflammation in macrophages. PON1 and catalase upregulated gene expression indicative of a compensatory response to oxidative stress associated with the treatment. Oxidative stress and inflammation mediated macrophages responses strongly linked to atherosclerosis pathogenesis.

Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation

Shock ◽  
2015 ◽  
Vol 44 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Patrick S. Tawadros ◽  
Kinga A. Powers ◽  
Menachem Ailenberg ◽  
Simone E. Birch ◽  
John C. Marshall ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Murine Macrophages ◽  
Ceramide Generation

Effect of Size Fractionation on the Toxicity of Amosite and Libby Amphibole Asbestos

2010 ◽  
Vol 118 (2) ◽  
pp. 420-434 ◽  
Author(s):  
Kelly E. Duncan ◽  
Andrew J. Ghio ◽  
Lisa A. Dailey ◽  
Amy M. Bern ◽  
Eugene A. Gibbs-Flournoy ◽  
...  
Keyword(s):  
Size Fractionation ◽  
Amphibole Asbestos ◽  
Libby Amphibole
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