Enhanced Expression of Metallothionein Isoform 3 Protein in Tumor Heterotransplants Derived from As+3- and Cd+2-Transformed Human Urothelial Cells

Xu Dong Zhou; Mary Ann Sens; Scott H. Garrett; Seema Somji; Seongmi Park; Volkan Gurel; Donald A. Sens

doi:10.1093/toxsci/kfl065

Enhanced Expression of Metallothionein Isoform 3 Protein in Tumor Heterotransplants Derived from As+3- and Cd+2-Transformed Human Urothelial Cells

Toxicological Sciences ◽

10.1093/toxsci/kfl065 ◽

2006 ◽

Vol 93 (2) ◽

pp. 322-330 ◽

Cited By ~ 10

Author(s):

Xu Dong Zhou ◽

Mary Ann Sens ◽

Scott H. Garrett ◽

Seema Somji ◽

Seongmi Park ◽

...

Keyword(s):

Urothelial Cells ◽

Enhanced Expression ◽

Metallothionein Isoform 3

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Enhanced expression of TGFβ, collagen, and TIMP-1 genes in esophageal stricture

Gastroenterology ◽

10.1016/s0016-5085(01)80755-1 ◽

2001 ◽

Vol 120 (5) ◽

pp. A153-A153

Author(s):

M KLINE ◽

Z ZANG ◽

K PATEL ◽

S FRENCH ◽

H TSUKAMOTO

Keyword(s):

Esophageal Stricture ◽

Enhanced Expression

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56: Substance P-Induced Expression of CD74 (Receptor for Macrophage Migration Inhibitory Factor) on the cell Surface of Urothelial cells in vivo

The Journal of Urology ◽

10.1016/s0022-5347(18)30321-5 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 19-19

Author(s):

Katherine L. Meyer-Siegler ◽

Pedro L. Vera

Keyword(s):

Substance P ◽

Cell Surface ◽

Migration Inhibitory Factor ◽

Macrophage Migration Inhibitory Factor ◽

Inhibitory Factor ◽

Macrophage Migration ◽

Urothelial Cells ◽

Induced Expression

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150: The Effect of Epidermal Growth Factor (EGF) on Inward Potassium Rectifying Currents in Bladder Urothelial Cells

The Journal of Urology ◽

10.1016/s0022-5347(18)34415-x ◽

2005 ◽

Vol 173 (4S) ◽

pp. 41-41

Author(s):

P. Sean Van Zijl ◽

Yan Sun ◽

Mingkui Chen ◽

Marc Simard ◽

Toby C. Chai

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Urothelial Cells ◽

Epidermal Growth

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976: Overexpression of Aurora A / STK15/ BTAK Induces Chromosomal Missegregation and Aneuploidy in Urothelial Cells

The Journal of Urology ◽

10.1016/s0022-5347(18)38213-2 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 258-259

Author(s):

Noriyoshi Tanaka ◽

Subrata Sen ◽

Bogdan A. Czerniak ◽

H. Barton Grossman

Keyword(s):

Aurora A ◽

Urothelial Cells

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Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000048 ◽

2011 ◽

Vol 81 (1) ◽

pp. 34-42 ◽

Cited By ~ 1

Author(s):

Joel Deneau ◽

Taufeeq Ahmed ◽

Roger Blotsky ◽

Krzysztof Bojanowski

Keyword(s):

Dna Microarrays ◽

Human Fibroblasts ◽

Diabetic Animal ◽

In Vitro Tests ◽

Diabetic Mice ◽

Fossil Material ◽

Expression Of Genes ◽

Enhanced Expression ◽

Genetically Diabetic Mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

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