scholarly journals Phenotypic Anchoring of Acetaminophen-Induced Oxidative Stress with Gene Expression Profiles in Rat Liver

2006 ◽  
Vol 93 (1) ◽  
pp. 213-222 ◽  
Author(s):  
Christine L. Powell ◽  
Oksana Kosyk ◽  
Pamela K. Ross ◽  
Robert Schoonhoven ◽  
Gunnar Boysen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Rat Liver ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Phenotypic Anchoring

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

2012 ◽  
Vol 86 (9) ◽  
pp. 1399-1411 ◽  
Author(s):  
Tatyana Y. Doktorova ◽  
Heidrun Ellinger-Ziegelbauer ◽  
Mathieu Vinken ◽  
Tamara Vanhaecke ◽  
Joost van Delft ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Rat Hepatocytes ◽  
Primary Rat Hepatocytes

Gene expression profiles predict the possible regulatory role of OPN-mediated signaling pathways in rat liver regeneration

Gene ◽  
2016 ◽  
Vol 576 (2) ◽  
pp. 782-790 ◽  
Author(s):  
Gaiping Wang ◽  
Shasha Chen ◽  
Congcong Zhao ◽  
Xiaofang Li ◽  
Ling Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Liver Regeneration ◽  
Signaling Pathways ◽  
Rat Liver ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Regulatory Role ◽  
Rat Liver Regeneration

Gene Expression Profiles in Rat Liver Slices Exposed to Hepatocarcinogenic Enzyme Inducers, Peroxisome Proliferators, and 17α-Ethinylestradiol

2006 ◽  
Vol 25 (5) ◽  
pp. 379-395 ◽  
Author(s):  
Gisela Werle-Schneider ◽  
Andreas Wölfelschneider ◽  
Marie Charlotte von Brevern ◽  
Julia Scheel ◽  
Thorsten Storck ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
Mode Of Action ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Peroxisome Proliferators ◽  
Liver Slices ◽  
Enzyme Inducers

Transcription profiling is used as an in vivo method for predicting the mode-of-action class of nongenotoxic carcinogens. To set up a reliable in vitro short-term test system DNA microarray technology was combined with rat liver slices. Seven compounds known to act as tumor promoters were selected, which included the enzyme inducers phenobarbital, α-hexachlorocyclohexane, and cyproterone acetate; the peroxisome proliferators WY-14,643, dehydroepiandrosterone, and ciprofibrate; and the hormone 17 α-ethinylestradiol. Rat liver slices were exposed to various concentrations of the compounds for 24 h. Toxicology-focused TOXaminer™ DNA microarrays containing approximately 1500 genes were used for generating gene expression profiles for each of the test compound. Hierarchical cluster analysis revealed that (i) gene expression profiles generated in rat liver slices in vitro were specific allowing classification of compounds with similar mode of action and (ii) expression profiles of rat liver slices exposed in vitro correlate with those induced after in vivo treatment (reported previously). Enzyme inducers and peroxisome proliferators formed two separate clusters, confirming that they act through different mechanisms. Expression profiles of the hormone 17 α-ethinylestradiol were not similar to any of the other compounds. In conclusion, gene expression profiles induced by compounds that act via similar mechanisms showed common effects on transcription upon treatment in vivo and in rat liver slices in vitro.

Gene expression profiles of drug-metabolizing enzymes (DMEs) in rat liver during pregnancy and lactation

2007 ◽  
Vol 83 (3) ◽  
pp. 428-434 ◽  
Author(s):  
Xi Jun He ◽  
Hirofumi Yamauchi ◽  
Kazuhiko Suzuki ◽  
Masaki Ueno ◽  
Hiroyuki Nakayama ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Pregnancy And Lactation

scholarly journals A new approach to construct pathway connected networks and its application in dose responsive gene expression profiles of rat liver regulated by 2,4DNT

BMC Genomics ◽  
2010 ◽  
Vol 11 (Suppl 3) ◽  
pp. S4 ◽  
Author(s):  
Sudhir Chowbina ◽  
Youping Deng ◽  
Junmei Ai ◽  
Xiaogang Wu ◽  
Xin Guan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
New Approach ◽  
Responsive Gene
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