scholarly journals Correlating Nanoscale Titania Structure with Toxicity: A Cytotoxicity and Inflammatory Response Study with Human Dermal Fibroblasts and Human Lung Epithelial Cells

2006 ◽  
Vol 92 (1) ◽  
pp. 174-185 ◽  
Author(s):  
Christie M. Sayes ◽  
Rajeev Wahi ◽  
Preetha A. Kurian ◽  
Yunping Liu ◽  
Jennifer L. West ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Response ◽  
Human Lung ◽  
Dermal Fibroblasts ◽  
Lung Epithelial Cells ◽  
Human Dermal Fibroblasts ◽  
Lung Epithelial ◽  
Human Lung Epithelial Cells

Dexamethasone inhibits inflammatory response via down regulation of AP-1 transcription factor in human lung epithelial cells

Gene ◽  
2018 ◽  
Vol 645 ◽  
pp. 85-94 ◽  
Author(s):  
Rajeshwari H. Patil ◽  
M. Naveen Kumar ◽  
K.M. Kiran Kumar ◽  
Rashmi Nagesh ◽  
K. Kavya ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Epithelial Cells ◽  
Inflammatory Response ◽  
Human Lung ◽  
Lung Epithelial Cells ◽  
Down Regulation ◽  
Lung Epithelial ◽  
Human Lung Epithelial Cells

Styrene induces an inflammatory response in human lung epithelial cells via oxidative stress and NF-κB activation

2008 ◽  
Vol 231 (2) ◽  
pp. 241-247 ◽  
Author(s):  
Carmen Röder-Stolinski ◽  
Gundula Fischäder ◽  
Gertie Janneke Oostingh ◽  
Ralph Feltens ◽  
Franziska Kohse ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Inflammatory Response ◽  
Human Lung ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Human Lung Epithelial Cells

scholarly journals Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway

2017 ◽  
Vol 43 (1) ◽  
pp. 17-30 ◽  
Author(s):  
Katharina Mörs ◽  
Jason-Alexander Hörauf ◽  
Shinwan Kany ◽  
Nils Wagner ◽  
Ramona Sturm ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Inflammatory Response ◽  
Acute Inflammation ◽  
Human Lung ◽  
A549 Cells ◽  
Lung Epithelial Cells ◽  
Neutrophil Adhesion ◽  
Lung Epithelial ◽  
Nuclear Levels ◽  
Human Lung Epithelial Cells

Background/Aims: Alcohol (ethanol, EtOH) as significant contributor to traumatic injury is linked to suppressed inflammatory response, thereby influencing clinical outcomes. Alcohol-induced immune-suppression during acute inflammation (trauma) was linked to nuclear factor-kappaB (NF-ĸB). Here, we analyzed alcohol`s effects and mechanisms underlying its influence on NF-ĸB-signaling during acute inflammation in human lung epithelial cells. Methods: A549-cells were stimulated with interleukin (IL)-1β, or sera from trauma patients (TP) or healthy volunteers, with positive/negative blood alcohol concentrations (BAC), and subsequently exposed to EtOH (170 Mm, 1h). IL-6-release and neutrophil adhesion to A549 were analyzed. Specific siRNA-NIK mediated downregulation of non-canonical, and IKK-NBD-inhibition of canonical NF-ĸB signaling were performed. Nuclear levels of activated p50 and p52 NF-ĸB-subunits were detected using TransAm ELISA. Results: Both stimuli significantly induced IL-6-release (39.79±4.70 vs. 0.58±0.8 pg/ml) and neutrophil adhesion (132.30±8.80 vs. 100% control, p<0.05) to A549-cells. EtOH significantly decreased IL-6-release (22.90±5.40, p<0.05) and neutrophil adherence vs. controls (105.40±14.5%, p<0.05). IL-1β-induced significant activation of canonical/p50 and non-canonical/p52 pathways. EtOH significantly reduced p50 (34.90±23.70 vs. 197.70±36.43, p<0.05) not p52 activation. Inhibition of canonical pathway was further increased by EtOH (less p50-activation), while p52 remained unaltered. Inhibition of non-canonical pathway was unchanged by EtOH. Conclusion: Here, alcohol`s anti-inflammatory effects are mediated via decreasing nuclear levels of activated p50-subunit and canonical NF-ĸB signaling pathway.

Legionella pneumophila induced microRNA expression in human lung epithelial cells

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
B Schmeck ◽  
B Dolniak ◽  
I Pollock ◽  
C Schulz ◽  
W Bertrams ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Legionella Pneumophila ◽  
Human Lung ◽  
Microrna Expression ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Human Lung Epithelial Cells
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