scholarly journals Deregulation of Cell Proliferation by Polycyclic Aromatic Hydrocarbons in Human Breast Carcinoma MCF-7 Cells Reflects Both Genotoxic and Nongenotoxic Events

2004 ◽  
Vol 83 (2) ◽  
pp. 246-256 ◽  
Author(s):  
M. Pliskova
Keyword(s):  
Cell Proliferation ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Breast Carcinoma ◽  
Aromatic Hydrocarbons ◽  
Human Breast Carcinoma ◽  
Human Breast ◽  
Polycyclic Aromatic ◽  
Mcf 7

Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells

2004 ◽  
Author(s):  
Young-Ae Kim ◽  
Byung Choi ◽  
Yong Lee ◽  
Dong Park ◽  
Sook-Hee Rhee ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Breast Carcinoma ◽  
Human Breast Carcinoma ◽  
Human Breast ◽  
Mcf 7

scholarly journals In Vitro Study on Apoptosis Induced by Strontium-89 in Human Breast Carcinoma Cell Line

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Cheng Wang ◽  
Jing Wang ◽  
Han Jiang ◽  
Min Zhu ◽  
Baoguo Chen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Breast Carcinoma ◽  
Transmembrane Potential ◽  
Human Breast Carcinoma ◽  
Inhibition Rate ◽  
Human Breast ◽  
Radioactive Concentration ◽  
Mcf 7

Many radiopharmaceuticals used for medical diagnosis and therapy are beta emitters; however, the mechanism of the cell death caused by beta-irradiation is not well understood. The objective of this study was to investigate the apoptosis of human breast carcinoma MCF-7 cell lines induced by Strontium-89 (89Sr) and its regulation and control mechanism. High-metastatic Breast Carcinoma MCF-7 cells were cultured in vitro using89Sr with different radioactive concentration. The inhibition rate of cell proliferation was measured by MTT color matching method. The cell cycle retardation, apoptosis conditions, mitochondrion transmembrane potential difference and Fas expression were tested and analyzed. The genes P53 and bcl-2 expressions was also analyzed using immunity histochemical analysis. After being induced by89Sr with various of radioactive concentration, it was found that the inhibition of cell proliferation of MCF-7 cells was obviously, the retardation of cell cycle occurred mainly in G2-M. It was also found that the obvious apoptosis occurred after being induced by89Sr, the highest apoptosis rate reached 46.28%. The expressions of Fas acceptor and P53 gene increased, while bcl-2 gene expression decreasesd. These findings demonstrate that in the ranges of a certain radioactive concentration, the inhibition rate of MCF-7 cell proliferation and retardation of cell cycle had positive correlation with the concentration of89Sr. And the mitochondrion transmembrane potential decrease would induce the apoptosis of MCF-7 cell notably, which were controlled by P53 and bcl-2 genes, involved with the Fas acceptor.

scholarly journals Estradiol Exposure Differentially Alters Monolayer versus Microtissue MCF-7 Human Breast Carcinoma Cultures

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0157997 ◽  
Author(s):  
Marguerite M. Vantangoli ◽  
Samantha J. Madnick ◽  
Shelby Wilson ◽  
Kim Boekelheide
Keyword(s):  
Breast Carcinoma ◽  
Human Breast Carcinoma ◽  
Human Breast ◽  
Mcf 7
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