scholarly journals Subchronic Toxicity of Triethylenetetramine Dihydrochloride in B6C3F1 Mice and F344 Rats

1996 ◽  
Vol 29 (2) ◽  
pp. 185-193
Author(s):  
DAVID L. GREENMAN ◽  
ROBERT L. MORRISSEY ◽  
WILLIAM BLAKEMORE ◽  
JAMES CROWELL ◽  
PAUL SIITONEN ◽  
...  
Keyword(s):  
Subchronic Toxicity ◽  
B6c3f1 Mice ◽  
F344 Rats

scholarly journals Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Inder Sehgal ◽  
Wallace D. Winters ◽  
Michael Scott ◽  
Andrew David ◽  
Glenn Gillis ◽  
...  
Keyword(s):  
Clinical Chemistry ◽  
Aloe Vera ◽  
Feed Consumption ◽  
Acute Administration ◽  
Subchronic Toxicity ◽  
Subacute Toxicity ◽  
National Toxicology Program ◽  
B6c3f1 Mice ◽  
F344 Rats ◽  
Leaf Juice

Aloe vera, a common ingredient in cosmetics, is increasingly being consumed as a beverage supplement. Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasia and ultimately malignancy. We tested a decolorized whole leaf (DCWL) aloe vera, treated with activated charcoal to remove the latex portion of the plant, for genotoxicity in bacteria, acute/subacute toxicity in B6C3F1 mice, and subchronic toxicity in F344 rats. We found this DCWL aloe vera juice to be nongenotoxic in histidine reversion and DNA repair assays. Following acute administration, mice exhibited no adverse signs at 3- or 14-day evaluation periods. When fed to male and female F344 rats over 13 weeks, DCWL aloe led to no toxicity as assessed by behavior, stools, weight gain, feed consumption, organ weights, and hematologic or clinical chemistry profiles. These rats had intestinal mucosal morphologies—examined grossly and microscopically—that were similar to controls. Our studies show that oral administration of this DCWL aloe juice has a different toxicology profile than that of the untreated aloe juice at exposures up to 13 weeks.

Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice[Cancer Lett. 193 (2003) 119–125]

2004 ◽  
Vol 207 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Ming W Chou ◽  
Jian Yan ◽  
Jasyl Nichols ◽  
Qingsu Xia ◽  
Frederick A Beland ◽  
...  
Keyword(s):  
Adduct Formation ◽  
Dna Adduct ◽  
B6c3f1 Mice ◽  
F344 Rats

scholarly journals Subchronic Toxicity Assessment of Phytolacca americana L. (Phytolaccaceae) in F344 Rats

2020 ◽  
Vol 15 (7) ◽  
pp. 1934578X2094165
Author(s):  
Hyoung-Yun Han ◽  
Kang-Hyun Han ◽  
Jun-Ho Ahn ◽  
Se-Myo Park ◽  
Soojin Kim ◽  
...  
Keyword(s):  
Body Weight ◽  
Adverse Effects ◽  
Clinical Chemistry ◽  
Toxicity Assessment ◽  
Phytolacca Americana ◽  
Subchronic Toxicity ◽  
Experimental Conditions ◽  
Male And Female ◽  
Long Term Treatment ◽  
F344 Rats

Phytolacca americana L. is traditionally used in Korea, Japan, and China as a diuretic, antibacterial, antiviral, anticancer, and anti-inflammatory agent, and also in the treatment of hepatitis B, psoriasis, edema, and rheumatism. In this study, we evaluated the subchronic toxicity of an aqueous extract of P. americana (PAAE) in male and female F344 rats. The rats were orally administered PAAE (0, 500, 1000, and 2000 mg/kg body weight) once daily for 13 weeks. Mortality rate, body weight, food consumption, and organ weights were measured and assessed. Additionally, ophthalmological, hematological, and histopathological parameters were evaluated. Urinalysis and necropsy were also performed. The clinical chemistry values for potassium in the treated female groups (500, 1000, and 2000 mg/kg/ body weight/day) were higher than those in the control. Further, the relative weights of the kidneys in the treated female groups (1000 and 2000 mg/kg/ body weight/day) were higher than those in the control. However, these changes were not consistent in either sex, and no abnormalities were found in the corresponding pathological findings. Thus the results showed no adverse effects in all the parameters assessed. The findings show that after 13 weeks of treatment, the “no-observed-adverse-effect level” of PAAE is 2000 mg/kg body weight in both male and female F344 rats under the experimental conditions applied. Although treatment-related adverse effects were not seen, potassium-level changes in the blood should be examined to establish the safety profile of PAAE after long-term treatment.

Subchronic Toxicity of Propantheline Bromide Administered in the Feed to Fischer 344/N Rates and B6C3F1 Mice

1987 ◽  
Vol 9 (3) ◽  
pp. 496-503
Author(s):  
JUNE K. DUNNICK ◽  
C. W. JAMESON ◽  
CHARLES A. MONTGOMERY
Keyword(s):  
Subchronic Toxicity ◽  
Fischer 344 ◽  
B6c3f1 Mice ◽  
N Rates ◽  
Propantheline Bromide

scholarly journals Metabolism and Disposition of Phenolphthalein in Male and Female F344 Rats and B6C3F1 Mice

1998 ◽  
Vol 42 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Robert J. Griffin ◽  
Veronica B. Godfrey ◽  
Leo T. Burka
Keyword(s):  
Male And Female ◽  
B6c3f1 Mice ◽  
F344 Rats

13‐Week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice

1987 ◽  
Vol 22 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Masa‐Aki Shibata ◽  
Yasushi Kurata ◽  
Seiko Tamano ◽  
Tadashi Ogiso ◽  
Shoji Fukushima ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Toxicity Study ◽  
Acid Salt ◽  
Subchronic Toxicity ◽  
B6c3f1 Mice

Subchronic toxicity study of gallic acid by oral administration in F344 rats

2001 ◽  
Vol 39 (11) ◽  
pp. 1063-1070 ◽  
Author(s):  
N Niho ◽  
M Shibutani ◽  
T Tamura ◽  
K Toyoda ◽  
C Uneyama ◽  
...  
Keyword(s):  
Oral Administration ◽  
Gallic Acid ◽  
Toxicity Study ◽  
Subchronic Toxicity ◽  
F344 Rats
Sign in / Sign up

Export Citation Format

Share Document