scholarly journals Impacts of Flunixin Meglumine injection on pain responses of either rubber ring castrated and tail docked lambs or surgically castrated and docked lambs

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. S48-S52
Author(s):  
Paige P Anderson ◽  
Amanda M Long ◽  
Alison R Crane ◽  
Travis W Hoffman ◽  
Gerald Stokka ◽  
...  
Keyword(s):  
Rubber Ring ◽  
Flunixin Meglumine ◽  
Pain Responses

scholarly journals PSI-41 Impacts of Flunixin Meglumine injection on wound score and swelling appearance of either rubber ring castrated and tail docked or surgically castrated and docked lambs

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 470-470
Author(s):  
Paige P Anderson ◽  
Amanda M Long ◽  
Alison R Crane ◽  
Travis W Hoffman ◽  
Gerald Stokka ◽  
...  
Keyword(s):  
Wound Healing ◽  
Post Treatment ◽  
Assessment Scale ◽  
Rubber Ring ◽  
Flunixin Meglumine ◽  
Randomized Design ◽  
Wound Assessment ◽  
Scrotal Swelling ◽  
Completely Randomized Design ◽  
Ram Lambs

Abstract Our hypothesis was that administering Flunixin Meglumine (FM) to lambs that were either rubber ring castrated and docked (RR) or surgically castrated and emasculator docked (SC) would decrease swelling and wound appearance score. Rambouillet ram lambs (n = 181) were allocated in a completely randomized design in a 2 x 2 factorial arrangement of treatments to determine the effects of RR or SC and emasculator docking on ram lambs with administration of FM (2.2 mg/kg of BW) or saline (S; 2.2 mg/kg of BW). Wounds were assessed on days 4 and 7 post-treatment. The Wound Assessment Scale ranged from 1 – 5 and was determined from levels of discharge, scabbing, and wound healing. The swelling score was also a 1 - 5 scale, varying from no swelling, large amounts, or healed. Scrotal wound exhibited a treatment x day interaction (P < 0.001), however tail wound score (P = 0.84) and scrotal swelling (P = 0.36) were not affected. The SC treated lambs had a higher wound score on day 4 and 7 when compared to the RR treated lambs for both the scrotum and tail score (P < 0.001). Flunixin Meglumine had no effect on wound score of the scrotum (P > 0.50) and tail (P > 0.43) for both RR and SC groups. However, RR treated lambs had higher swelling scores on day 4 and 7 (P < 0.001). Flunixin Meglumine administration did not influence swelling score in treated lambs (P > 0.43). Surgical castration resulted in an increase in wound score compared to rubber ring castrated and docked lambs, but rubber ring castrated and docked lambs had an increase in wound swelling. Flunixin Meglumine did not have an impact on either wound score or wound swelling, regardless of castration method.

scholarly journals 273 Impacts of Flunixin Meglumine injection on pain responses of either rubber ring castrated and tail docked or surgically castrated and docked lambs

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 189-190
Author(s):  
Paige P Anderson ◽  
Amanda M Long ◽  
Alison R Crane ◽  
Travis W Hoffman ◽  
Gerald Stokka ◽  
...  
Keyword(s):  
Physiological Stress ◽  
Average Daily Gain ◽  
Serum Cortisol ◽  
Post Treatment ◽  
Rubber Ring ◽  
Time Interaction ◽  
Flunixin Meglumine ◽  
Haptoglobin Concentration ◽  
Ram Lambs ◽  
Daily Gain

Abstract Our hypothesis was that administering Flunixin Meglumine (FM) to lambs that were either rubber ring castrated and docked or surgically castrated and emasculator docked would decrease behavioral stress, serum cortisol and haptoglobin concentration, but increase average daily gain. Rambouillet ram lambs (n = 181) were allocated with a completely randomized design in a 2 x 2 factorial arrangement of treatments. Treatment combinations included rubber ring castration and tail docking (RR; placement of rubber band at distal end of caudal fold and around the base of the testicles) or surgical castration (SC; surgical scissors removing the lower third of the scrotum and testicles removed manually) and emasculator docking (crushing the tail at the distal end of the caudal fold, followed by cutting of the tail) on ram lambs with administration of saline (S) or FM (2.2 mg/kg of BW; RR-S, RR-FM, SC-S, SC-FM). Ram lambs were castrated at 12.5 ± 5.5 days of age and observed for behavioral changes such as lying down, leg extension and walking for 180 min in 30-min increments. Blood samples were taken at -30, 30, 90- and 140-minutes post-treatment to observe cortisol and haptoglobin levels. Behavioral traits, physiological traits, and average daily gain were analyzed in PROC GENMOD (SAS Inst. Inc., Cary, NC). A treatment x time interaction (P < 0.001) occurred for lamb pain behavioral scale, where scores at 30, 60, and 180 minutes after castration and docking exhibited differences among treatments. Average daily gain was not affected by a treatment x time interaction (P = 0.22) or treatment (P = 0.50) main effect. Serum cortisol concentration exhibited a treatment x time interaction (P = 0.002). The SC-FM lambs had lower cortisol concentrations (P = 0.004) than all other treatments at 90 min post-treatment, with the SC-S lambs having higher concentrations (P < 0.001) at 140 min post-treatment. Haptoglobin concentration did not exhibit a treatment x time interaction (P = 0.99); however, treatment and age were significant (P < 0.004). The RR-S lambs had an increase concentration of haptoglobin with SC-FM lambs being intermediate. Overall, results indicate that the method of castration and docking in lambs affected short lived behavioral and physiological stress, with the administration of FM decreasing stress regardless of castration and docking method.

358: Intravesical Botulinum Toxin a Administration Produces Analgesia Against Acetic Acid Induced Bladder Pain Responses in Rats

2004 ◽  
Vol 171 (4S) ◽  
pp. 94-94
Author(s):  
Yao-Chi Chuang ◽  
Naoki Yoshimura ◽  
Chao-Cheng Huang ◽  
Po-Hui Chiang ◽  
Michael B. Chancellor
Keyword(s):  
Acetic Acid ◽  
Botulinum Toxin ◽  
Botulinum Toxin A ◽  
Toxin A ◽  
Bladder Pain ◽  
Pain Responses

scholarly journals Investigation of an EHV-1 Outbreak in the United States Caused by a New H752 Genotype

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 747
Author(s):  
Nicola Pusterla ◽  
Samantha Barnum ◽  
Julia Miller ◽  
Sarah Varnell ◽  
Barbara Dallap-Schaer ◽  
...  
Keyword(s):  
Early Stage ◽  
Clinical Signs ◽  
Amino Acid Position ◽  
High Viral Load ◽  
The United States ◽  
Neurological Deficits ◽  
Diagnostic Challenge ◽  
Genotype I ◽  
Flunixin Meglumine ◽  
Nasal Secretions

Here we report on an EHV-1 outbreak investigation caused by a novel genotype H752 (histidine in amino acid position 752 of the ORF 30 gene). The outbreak involved 31 performance horses. Horses were monitored over a period of 35 days for clinical signs, therapeutic outcome and qPCR results of EHV-1 in blood and nasal secretions. The morbidity of the EHV-1 outbreak was 84% with 26 clinically infected horses displaying fever and less frequently anorexia and distal limb edema. Four horses showed mild transient neurological deficits. Clinically diseased horses experienced high viral load of EHV-1 in blood and/or nasal secretions via qPCR, while subclinically infected horses had detectable EHV-1 mainly in nasal secretions. The majority of infected horses showed a rise in antibody titers to EHV-1 during the outbreak. All 31 horses were treated with valacyclovir, while clinically infected horses further received flunixin meglumine and sodium heparin. This investigation highlights various relevant aspects of an EHV-1 outbreak caused by a new H752 genotype: (i) importance of early detection of EHV-1 infection; (ii) diagnostic challenge to assess H752 genotype; (iii) apparent benefit of valacyclovir use in the early stage of the outbreak; and (iv) weekly testing of blood and nasal secretions by qPCR in order to monitor individual infection status and lift quarantine.

Spinal and supraspinal modulation of pain responses by hypnosis, suggestions, and distraction

2021 ◽  
Vol 63 (4) ◽  
pp. 329-354
Author(s):  
Bérengère Houzé ◽  
Anouk Streff ◽  
Mathieu Piché ◽  
Pierre Rainville
Keyword(s):  
Pain Responses

scholarly journals Flunixin Meglumine Reduces Milk Isoprostane Concentrations in Holstein Dairy Cattle Suffering from Acute Coliform Mastitis

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 834
Author(s):  
Carsten C. F. Walker ◽  
Jill L. Brester ◽  
Lorraine M. Sordillo
Keyword(s):  
Medical Intervention ◽  
Systemic Involvement ◽  
Analgesic Effects ◽  
Markers Of Inflammation ◽  
Inflammatory Mediator Production ◽  
Flunixin Meglumine ◽  
Coliform Mastitis ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Oxidant Status

Dysfunctional inflammation contributes significantly to the pathogenesis of coliform mastitis and the classical pro-inflammatory enzyme cyclooxygenase-2 (COX-2) is the target of medical intervention using the non-steroidal anti-inflammatory drug (NSAID) flunixin meglumine (FM). Inhibition of COX-2 by FM can decrease concentrations of pro-inflammatory fatty acid-based mediators called eicosanoids, providing antipyretic and analgesic effects in dairy cows suffering from coliform mastitis. However, approximately 50% of naturally occurring coliform mastitis with systemic involvement results in death of the animal, even with NSAID treatment. Inadequate antioxidant potential (AOP) to neutralize reactive oxygen species (ROS) produced during excessive inflammation allows for oxidative stress (OS), contributing to tissue damage during coliform mastitis. Biomarkers of lipid peroxidation by ROS, called isoprostanes (IsoP), were used in humans and cattle to quantify the extent of OS. Blood IsoP were shown to be elevated and correlate with oxidant status during acute coliform mastitis. However, the effect of FM treatment on oxidant status and markers of OS has not been established. Blood IsoP concentrations were used to quantify systemic OS, whereas milk was used to assess local OS in the mammary gland. Results indicate that FM treatment had no effect on blood markers of inflammation but reduced the oxidant status index (OSi) by increasing blood AOP from pre- to post-FM treatment. Milk AOP significantly increased from pre- to post-FM treatment, whereas ROS decreased, resulting in a decreased OSi from pre- to post-FM treatment. The only blood IsoP concentration that was significantly different was 5-iso-iPF2α-VI, with a decreased concentration from pre- to post-FM treatment. Conversely, milk 5-iso-iPF2α-VI, 8,12-iso-iPF2α-VI, and total IsoP concentrations were decreased following FM treatment. These results indicated that administration of FM did improve systemic and local oxidant status and reduced local markers of OS. However, differential effects were observed between those animals that survived the infection and those that died, indicating that pre-existing inflammation and oxidant status greatly affect efficacy of FM and may be the key to reducing severity and mortality associated with acute coliform infections. Supplementation to improve AOP and anti-inflammatory mediator production may significantly improve efficacy of FM treatment.

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