scholarly journals Consistent altered internal capsule white matter microstructure in insomnia disorder

SLEEP ◽  
2020 ◽  
Vol 43 (8) ◽  
Author(s):  
Tom Bresser ◽  
Jessica C Foster-Dingley ◽  
Rick Wassing ◽  
Jeanne Leerssen ◽  
Jennifer R Ramautar ◽  
...  
Keyword(s):  
White Matter ◽  
Internal Capsule ◽  
Mixed Effect ◽  
Significant Group ◽  
Consistent Finding ◽  
White Matter Microstructure ◽  
Insomnia Disorder ◽  
Underlying Mechanisms ◽  
The Right ◽  
Insomnia Severity

Abstract Study Objectives Suggested neural correlates of insomnia disorder have been hard to replicate. Even the most consistent finding, altered white matter microstructure in the anterior limb of the internal capsule, is based on handful studies. The urge for replicable targets to understand the underlying mechanisms of insomnia made us study white matter fractional anisotropy (FA) across three samples of cases and controls. Methods 3-Tesla MRI diffusion tensor imaging data of three independent samples were combined for analysis, resulting in n = 137 participants, of whom 73 were diagnosed with insomnia disorder and 64 were matched controls without sleep complaints. Insomnia severity was measured with the Insomnia Severity Index (ISI). White matter microstructure was assessed with FA. White matter tracts were skeletonized and analyzed using tract-based spatial statistics. We performed a region-of-interest analysis using linear mixed-effect models to evaluate case–control differences in internal capsule FA as well as associations between internal capsule FA and insomnia severity. Results FA in the right limb of the anterior internal capsule was lower in insomnia disorder than in controls (β = −9.76e−3; SE = 4.17e−3, p = .034). In the entire sample, a higher ISI score was associated with a lower FA value of the right internal capsule (β = −8.05e− 4 FA/ISI point, SE = 2.60e− 4, p = .008). Ancillary whole brain voxel-wise analyses showed no significant group difference or association with insomnia severity after correction for multiple comparisons. Conclusions The internal capsule shows small but consistent insomnia-related alterations. The findings support a circuit-based approach to underlying mechanisms since this tract connects many brain areas previously implicated in insomnia.

White Matter Alteration Following SWAT Explosive Breaching Training and the Moderating Effect of a Neck Collar Device: A DTI and NODDI Study

2021 ◽  
Author(s):  
Weihong Yuan ◽  
Jonathan Dudley ◽  
Alexis B Slutsky-Ganesh ◽  
James Leach ◽  
Pete Scheifele ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Moderating Effect ◽  
Significant Group ◽  
Blast Exposure ◽  
Diffusion Weighted ◽  
Weighted Data ◽  
The Right ◽  
The Impact

ABSTRACT Introduction Special Weapons and Tactics (SWAT) personnel who practice breaching with blast exposure are at risk for blast-related head trauma. We aimed to investigate the impact of low-level blast exposure on underlying white matter (WM) microstructure based on diffusion tensor imaging (DTI) and neurite orientation and density imaging (NODDI) in SWAT personnel before and after breacher training. Diffusion tensor imaging is an advanced MRI technique sensitive to underlying WM alterations. NODDI is a novel MRI technique emerged recently that acquires diffusion weighted data from multiple shells modeling for different compartments in the microstructural environment in the brain. We also aimed to evaluate the effect of a jugular vein compression collar device in mitigating the alteration of the diffusion properties in the WM as well as its role as a moderator on the association between the diffusion property changes and the blast exposure. Materials and Methods Twenty-one SWAT personnel (10 non-collar and 11 collar) completed the breacher training and underwent MRI at both baseline and after blast exposure. Diffusion weighted data were acquired with two shells (b = 1,000, 2,000 s/mm2) on 3T Phillips scanners. Diffusion tensor imaging metrices, including fractional anisotropy, mean, axial, and radial diffusivity, and NODDI metrics, including neurite density index (NDI), isotropic volume fraction (fiso), and orientation dispersion index, were calculated. Tract-based spatial statistics was used in the voxel-wise statistical analysis. Post hoc analyses were performed for the quantification of the pre- to post-blast exposure diffusion percentage change in the WM regions with significant group difference and for the assessment of the interaction of the relationship between blast exposure and diffusion alteration. Results The non-collar group exhibited significant pre- to post-blast increase in NDI (corrected P < .05) in the WM involving the right internal capsule, the right posterior corona radiation, the right posterior thalamic radiation, and the right sagittal stratum. A subset of these regions showed significantly greater alteration in NDI and fiso in the non-collar group when compared with those in the collar group (corrected P < .05). In addition, collar wearing exhibited a significant moderating effect for the alteration of fiso for its association with average peak pulse pressure. Conclusions Our data provided initial evidence of the impact of blast exposure on WM diffusion alteration based on both DTI and NODDI. The mitigating effect of WM diffusivity changes and the moderating effect of collar wearing suggest that the device may serve as a promising solution to protect WM against blast exposure.

Changes in mild cognitive impairment and its subtypes as seen on diffusion tensor imaging

2012 ◽  
Vol 24 (9) ◽  
pp. 1483-1493 ◽  
Author(s):  
Senthil Thillainadesan ◽  
Wei Wen ◽  
Lin Zhuang ◽  
John Crawford ◽  
Nicole Kochan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Multiple Testing ◽  
Diffusion Tensor ◽  
Internal Capsule ◽  
Anterior Cingulate ◽  
Corona Radiata ◽  
Amnestic Mci ◽  
Subcortical Regions ◽  
The Right

ABSTRACTBackground: Previous studies using diffusion tensor imaging (DTI) have observed microstructural abnormalities in white matter regions in both Alzheimer's disease and mild cognitive impairment (MCI). The aim of this work was to examine the abnormalities in white matter and subcortical regions of MCI and its subtypes in a large, community-dwelling older aged cohortMethods: A community-based sample of 396 individuals without dementia underwent medical assessment, neuropsychiatric testing, and neuroimaging. Of these, 158 subjects were classified as MCI and 238 as cognitively normal (controls) based on international MCI consensus criteria. Regional fractional anisotropy (FA) and mean diffusivity (MD) measures were calculated from the DTI and compared between groups. The false discovery rate correction was applied for multiple testing.Results: Subjects with MCI did not have significant differences in FA compared with controls after correction for multiple testing, but had increased MD in the right putamen, right anterior limb of the internal capsule, genu and splenium of the corpus callosum, right posterior cingulate gyrus, left superior frontal gyrus, and right and left corona radiata. When compared with controls, changes in left anterior cingulate, left superior frontal gyrus, and right corona radiata were associated with amnestic MCI (aMCI), whereas changes in the right putamen, right anterior limb of the internal capsule, and the right corona radiata were associated with non-amnestic MCI (naMCI). On logistic regression, the FA values in the left superior gyrus and MD values in the anterior cingulate distinguished aMCI from naMCI.Conclusions: MCI is associated with changes in white matter and subcortical regions as seen on DTI. Changes in some anterior brain regions distinguish aMCI from naMCI.

scholarly journals Microstructural anatomical differences between bilinguals and monolinguals

2017 ◽  
Vol 21 (5) ◽  
pp. 995-1008 ◽  
Author(s):  
NANDINI C. SINGH ◽  
ARCHITH RAJAN ◽  
ARCHANA MALAGI ◽  
KEERTHI RAMANUJAN ◽  
MATTEO CANINI ◽  
...  
Keyword(s):  
White Matter ◽  
Mean Diffusivity ◽  
English Speakers ◽  
Cerebral White Matter ◽  
Language Experience ◽  
Bilingual Speakers ◽  
White Matter Microstructure ◽  
Inferior Longitudinal Fasciculus ◽  
The Right ◽  
Anterior Thalamic Radiation

DTI is an established method to study cerebral white-matter microstructure. Two established measures of DTI are fractional anisotropy (FA) and mean diffusivity (MD) and both differ for bilingual and monolingual speakers. Less is known about differences in two other measures called radial (RD) and axial diffusivity (AD). We report differences in mean RD and AD-values in the right superior longitudinal fasciculus (SLF) and forceps minor between bilingual (Hindi–English) and monolingual (English) speakers as well as differences in mean FA-values in the anterior thalamic radiation, right inferior fronto-occipital and inferior longitudinal fasciculus (ILF) and mean MD-values in forceps minor and bilateral SLF. Noteworthy, a positive correlation between L2 proficiency and mean RD-values in the right SLF was observed. We suggest that changes in the geometry of white matter tracts reflect regular bilingual language experience and contend that neuroplasticity in right SLF results from demands on cognitive control for bilingual speakers.

scholarly journals Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents

2020 ◽  
Author(s):  
Kathrine Skak Madsen ◽  
Louise Baruël Johansen ◽  
Wesley K. Thompson ◽  
Hartwig R. Siebner ◽  
Terry L. Jernigan ◽  
...  
Keyword(s):  
White Matter ◽  
Children And Adolescents ◽  
Fractional Anisotropy ◽  
Motor Response ◽  
Stop Signal ◽  
Motor Area ◽  
Stop Signal Task ◽  
List Type ◽  
White Matter Microstructure ◽  
The Right

AbstractThe ability to effectively suppress motor response tendencies is essential for focused and goal-directed behavior. Here, we tested the hypothesis that developmental improvement in the ability to cancel a motor response is reflected by maturational changes in the white matter underlying the right presupplementary motor area (preSMA) and posterior inferior frontal gyrus (IFG), two cortical key areas of the fronto-basal ganglia “stopping” network. Eighty-eight typically-developing children and adolescents, aged 7-19 years, were longitudinally assessed with the stop-signal task (SST) and diffusion tensor imaging (DTI) of the brain over a period of six years. Participants were examined from two to nine times with an average of 6.6 times, resulting in 576 SST-DTI datasets. We applied tract-based spatial statistics to extract mean fractional anisotropy (FA) from regions-of-interest in the white matter underlying the right IFG (IFGFA) and right preSMA (preSMAFA) at each time point. Motor response cancelation performance, estimated with the stop-signal reaction time (SSRT), improved with age. Initially well performing children plateaued around the age of 11 years, while initially poor performers caught up at the age of 13-14 years. White matter microstructure continued to mature across the investigated age range. Males generally displayed linear maturational trajectories, while females displayed more curvilinear trajectories that leveled off around 12-14 years of age. Maturational increases in right preSMAFA but not right IFGFA were associated with developmental improvements in SSRT. This association differed depending on the mean right preSMAFA across the individual maturational trajectory. Children with lower mean right preSMAFA exhibited poorer SSRT performance at younger ages but steeper developmental trajectories of SSRT improvement. Children with higher mean right preSMAFA exhibited flatter trajectories of SSRT improvement along with faster SSRT already at the first assessments. The results suggest that no further improvement in motor response cancellation is achieved once a certain level of maturity in the white matter underlying the right preSMA is reached. Similar dynamics may apply to other behavioral read-outs and brain structures and, thus, need to be considered in longitudinal MRI studies designed to map brain structural correlates of behavioral changes during development.HighlightsMotor response cancellation, i.e. SSRT, improvement plateaued at 13-14 years of ageFractional anisotropy (FA) captured maturation of white matter (WM) microstructureFA in the WM underlying right preSMA (preSMAFA) reflected SSRT improvement with ageIndividual SSRT improvement depended on mean right preSMAFA across all DTI sessionsChildren with lower mean right preSMAFA had the steepest improvements in SSRT

scholarly journals Reorganizations of latency structure within white matter from wakefulness to sleep

2021 ◽  
Author(s):  
Bin Guo ◽  
Fugen Zhou ◽  
Guangyuan Zou ◽  
Jun Jiang ◽  
Qihong Zou ◽  
...  
Keyword(s):  
White Matter ◽  
Resting State ◽  
Internal Capsule ◽  
Nrem Sleep ◽  
Sleep Stages ◽  
Mixed Effect ◽  
Corona Radiata ◽  
Cross Covariance ◽  
Latency Analysis ◽  
The Brain

AbstractPrevious studies based on resting-state fMRI (rsfMRI) data have revealed the existence of highly reproducible latency structure, reflecting the propagation of BOLD fMRI signals, in white matter (WM). Here, based on simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data collected from 35 healthy subjects who were instructed to sleep, we explored the alterations of propagations in WM across wakefulness and nonrapid eye movement (NREM) sleep stages. Lagged cross-covariance was computed among voxel-wise time series, followed by parabolic interpolation to determine the actual latency value in-between. In WM, regions including cerebellar peduncle, internal capsule, posterior thalamic radiation, genu of corpus callosum, and corona radiata, were found to change their temporal roles drastically, as revealed by applying linear mixed-effect model on voxel-wise latency projections across wakefulness and NREM sleep stages. Using these regions as seeds, further seed-based latency analysis revealed that variations of latency projections across different stages were underlain by inconsistent temporal shifts between each seed and the remaining part of WM. Finally, latency analysis on resting-state networks (RSNs), obtained by applying k-means clustering technique on group-level functional connectivity matrix, identified a path of signal propagations similar to previous findings in EEG during wakefulness, which propagated mainly from the brainstem upward to internal capsule and further to corona radiata. This path showed inter-RSN temporal reorganizations depending on the paired stages between which the brain transitioned, e.g., it changed, between internal capsule and corona radiata, from mainly unidirectional to clearly reciprocal when the brain transitioned from wakefulness to N3 stage. These findings suggested the functional role of BOLD signals in white matter as a slow process, dynamically modulated across wakefulness and NREM sleep stages, and involving in maintaining different levels of consciousness and cognitive processes.

scholarly journals White matter microstructure in women with acute and remitted anorexia nervosa: an exploratory neuroimaging study

2018 ◽  
Author(s):  
Amy Miles ◽  
Allan Kaplan ◽  
Leon French ◽  
Aristotle Voineskos
Keyword(s):  
Anorexia Nervosa ◽  
White Matter ◽  
Time Course ◽  
Mean Diffusivity ◽  
Internal Capsule ◽  
Developmental Time ◽  
White Matter Microstructure ◽  
Main Effect ◽  
Healthy Control ◽  
Neuroimaging Study

Anorexia nervosa (AN) is a highly heritable psychiatric disorder characterized by starvation and emaciation and associated with changes in brain structure. The precise nature of these changes remains unclear, as does their developmental time course and capacity for reversal with weight restoration. In this exploratory neuroimaging study, we sought to characterize changes in white matter microstructure in women with acute and remitted AN. Diffusion-weighted MRI data was collected from underweight women with a current diagnosis of AN (acAN: n=23), weight-recovered women with a past diagnosis of AN (recAN: n=23), and age-matched healthy control women (HC: n=24). Image processing and analysis were performed with Tract-Based Spatial Statistics, part of FSL, and group differences in voxel-wise, brain-wide fractional anisotropy (FA) and mean diffusivity (MD), indices of white matter microstructure, were tested with nonparametric permutation and threshold free cluster enhancement. No significant main effect of group on FA was identified. A significant main effect of group on MD was observed in a large cluster covering 9.2% of white matter and including substantial portions of the corpus callosum, corona radiata, internal capsule, and superior longitudinal fasciculus, and post hoc analyses revealed similar effects of group on axial diffusivity (AD) and radial diffusivity (RD). Cluster-wise MD was significantly higher in acAN participants (+3.8%) and recAN participants (+2.9%) than healthy controls, and the same was true for cluster-wise AD and RD. Trait-based increases in diffusivity, consistent with atypical myelination and impaired axon integrity, suggest a link between altered white matter microstructure and vulnerability to AN, and evidence of reduced oligodendrocyte density in AN provides further support for this hypothesis. Potential mechanisms of action include atypical neurodevelopment and systemic inflammation.

scholarly journals Patients With Chronic Migraine Without History of Medication Overuse Are Characterized by a Peculiar White Matter Fiber Bundle Profile

2020 ◽  
Author(s):  
Gianluca Coppola ◽  
Antonio Di Renzo ◽  
Emanuele Tinelli ◽  
Barbara Petolicchio ◽  
Cherubino Di Lorenzo ◽  
...  
Keyword(s):  
White Matter ◽  
Chronic Migraine ◽  
Diffusion Tensor ◽  
Internal Capsule ◽  
Posterior Limb ◽  
History Of ◽  
The Right ◽  
Normal White Matter ◽  
Microstructural Integrity ◽  
The Brain

Abstract Background: We investigated intracerebral fiber bundles using a tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) datato investigate microstructural integrity in patients with episodic (MO) and chronic migraine (CM).Methods: We performed DTI in 19 patients with MO within interictal periods, 18 patients with CM without any history of drug abuse, and 18 healthy controls (HCs) using a 3T magnetic resonance imaging scanner. We calculated diffusion metrics, including fractional anisotropy (FA), axial diffusion (AD), radial diffusion (RD), and mean diffusion (MD).Results: TBSS revealed no significant differences in the FA, MD, RD, and AD maps between the MO and HC groups. In comparison to the HC group, theCM group exhibited widespread increased RD (bilateral superior [SCR] and posterior corona radiata [PCR], bilateral genu of the corpus callosum [CC], bilateral posterior limb of internal capsule [IC], bilateral superior longitudinal fasciculus [LF]) and MD values (tracts of the right SCR and PCR, right superior LF, and right splenium of the CC). In comparison to theMO group, theCM group showed decreased FA (bilateral SCR and PCR, bilateral body of CC, right superior LF, right forceps minor) and increased MD values (bilateral SCR and right PCR, right body of CC, right superior LF, right splenium of CC, and right posterior limb of IC). Conclusion: Our results suggest that chronic migraine can be associated withthe widespread disruption of normal white matter integrity in the brain.

scholarly journals White Matter Microstructure Correlates of General and Specific Second-Order Factors of Psychopathology

2018 ◽  
Author(s):  
Kendra E. Hinton ◽  
Benjamin B. Lahey ◽  
Victoria Villalta-Gil ◽  
Francisco A. C. Meyer ◽  
Leah L. Burgess ◽  
...  
Keyword(s):  
White Matter ◽  
Corpus Callosum ◽  
Internal Capsule ◽  
Case Control ◽  
Second Order ◽  
The Body ◽  
General Factor ◽  
Diagnostic Categories ◽  
White Matter Microstructure ◽  
Control Designs

AbstractIncreasing data indicate that prevalent forms of psychopathology can be organized into second-order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Despite this organization, and high levels of comorbidity between diagnoses, most existing studies on the neural correlates of psychopathology employ case-control designs that treat diagnoses as independent categories. Thus, for instance, although perturbations in white matter microstructure have been identified across a range of disorders, the majority of such studies have used case-control designs, leaving it unclear whether observed relations reflect disorder specific characteristics, or transdiagnostic patterns. Using a representative community twin sample of 410 young adults, we tested the hypothesis that some relations between white matter microstructure properties in major tracts are related to second-order factors of psychopathology. We examined fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). White matter correlates of all second-order factors were identified after controlling for multiple tests, including the general factor (FA in the body of the corpus callosum), specific internalizing (AD in the fornix), and specific externalizing (AD in the splenium of the corpus callosum, sagittal stratum, anterior corona radiata, and internal capsule). These findings suggest that features of white matter within specific tracts are associated with broad transdiagnostic dimensions of psychopathology rather than being restricted to individual diagnostic categories.

scholarly journals Tract Profiles of The Cerebellar Peduncles In Children Who Stutter

2021 ◽  
Author(s):  
Chelsea Johnson ◽  
Yanni Liu ◽  
Noah Waller ◽  
Soo-Eun Chang
Keyword(s):  
White Matter ◽  
Group Differences ◽  
Cerebellar White Matter ◽  
Significant Group ◽  
Input Processing ◽  
Structural Differences ◽  
Cerebellar Peduncles ◽  
The Right ◽  
Early Developmental ◽  
Structural Aspects

Abstract Cerebellar-cortical loops comprise critical neural circuitry that supports self-initiated movements and motor adjustments in response to perceived errors, functions that are affected in stuttering. It is unknown whether structural aspects of cerebellar circuitry are affected in stuttering, in particular in children close to symptom onset. Here we examined white matter diffusivity characteristics of the three cerebellar peduncles (CP) based on diffusion MRI (dMRI) data collected from 41 children who stutter (CWS) and 42 controls in the 3-11 year range. We hypothesized that CWS would exhibit decreased fractional anisotropy (FA) in the right CPs given the contralateral connectivity of the cerebellar-cortical loops and past reports of structural differences in left cortical areas in stuttering speakers. Automatic Fiber Quantification (AFQ) was used to track and segment cerebellar white matter pathways and to extract diffusivity measures. We found significant group differences for FA in the right Inferior CP (ICP) only: controls showed significantly higher FA in the right ventral ICP compared to CWS, controlling for age, sex, and verbal IQ. Furthermore, FA of right ICP was negatively correlated with stuttering frequency in CWS. These results suggest an early developmental difference in the right ICP for CWS compared to age-matched peers, which may indicate an alteration in error processing, a function previously linked to the ICP. Lower FA here may impact error monitoring and sensory input processing to guide motor corrections. Further longitudinal investigations in children may provide additional insights into how CP development links to stuttering persistence and recovery.

scholarly journals Patients with chronic migraine without history of medication overuse are characterized by a peculiar white matter fiber bundle profile

2020 ◽  
Author(s):  
Gianluca Coppola ◽  
Antonio Di Renzo ◽  
Emanuele Tinelli ◽  
Barbara Petolicchio ◽  
Cherubino Di Lorenzo ◽  
...  
Keyword(s):  
White Matter ◽  
Chronic Migraine ◽  
Diffusion Tensor ◽  
Internal Capsule ◽  
Posterior Limb ◽  
History Of ◽  
The Right ◽  
Normal White Matter ◽  
Microstructural Integrity ◽  
The Brain

Abstract Background: We investigated intracerebral fiber bundles using a tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) data to investigate microstructural integrity in patients with episodic (MO) and chronic migraine (CM).Methods: We performed DTI in 19 patients with MO within interictal periods, 18 patients with CM without any history of drug abuse, and 18 healthy controls (HCs) using a 3T magnetic resonance imaging scanner. We calculated diffusion metrics, including fractional anisotropy (FA), axial diffusion (AD), radial diffusion (RD), and mean diffusion (MD).Results: TBSS revealed no significant differences in the FA, MD, RD, and AD maps between the MO and HC groups. In comparison to the HC group, the CM group exhibited widespread increased RD (bilateral superior [SCR] and posterior corona radiata [PCR], bilateral genu of the corpus callosum [CC], bilateral posterior limb of internal capsule [IC], bilateral superior longitudinal fasciculus [LF]) and MD values (tracts of the right SCR and PCR, right superior LF, and right splenium of the CC). In comparison to the MO group, the CM group showed decreased FA (bilateral SCR and PCR, bilateral body of CC, right superior LF, right forceps minor) and increased MD values (bilateral SCR and right PCR, right body of CC, right superior LF, right splenium of CC, and right posterior limb of IC). Conclusion: Our results suggest that chronic migraine can be associated with the widespread disruption of normal white matter integrity in the brain.

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