scholarly journals Laughter is in the air: involvement of key nodes of the emotional motor system in the anticipation of tickling

2019 ◽  
Vol 14 (8) ◽  
pp. 837-847 ◽  
Author(s):  
Elise Wattendorf ◽  
Birgit Westermann ◽  
Klaus Fiedler ◽  
Simone Ritz ◽  
Annetta Redmann ◽  
...  
Keyword(s):  
Sensory Processing ◽  
Anterior Insula ◽  
Anterior Cingulate ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Periaqueductal Gray Matter ◽  
Internal Globus Pallidus ◽  
Posterior Insula ◽  
Anticipatory Activity ◽  
The Brain

Abstract In analogy to the appreciation of humor, that of tickling is based upon the re-interpretation of an anticipated emotional situation. Hence, the anticipation of tickling contributes to the final outburst of ticklish laughter. To localize the neuronal substrates of this process, functional magnetic resonance imaging (fMRI) was conducted on 31 healthy volunteers. The state of anticipation was simulated by generating an uncertainty respecting the onset of manual foot tickling. Anticipation was characterized by an augmented fMRI signal in the anterior insula, the hypothalamus, the nucleus accumbens and the ventral tegmental area, as well as by an attenuated one in the internal globus pallidus. Furthermore, anticipatory activity in the anterior insula correlated positively with the degree of laughter that was produced during tickling. These findings are consistent with an encoding of the expected emotional consequences of tickling and suggest that early regulatory mechanisms influence, automatically, the laughter circuitry at the level of affective and sensory processing. Tickling activated not only those regions of the brain that were involved during anticipation, but also the posterior insula, the anterior cingulate cortex and the periaqueductal gray matter. Sequential or combined anticipatory and tickling-related neuronal activities may adjust emotional and sensorimotor pathways in preparation for the impending laughter response.

scholarly journals Controllability over stressor decreases responses in key threat-related brain areas

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Chirag Limbachia ◽  
Kelly Morrow ◽  
Anastasiia Khibovska ◽  
Christian Meyer ◽  
Srikanth Padmala ◽  
...  
Keyword(s):  
Posterior Cingulate Cortex ◽  
Anterior Insula ◽  
Stria Terminalis ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Brain Areas ◽  
Bed Nucleus ◽  
Posterior Insula ◽  
Brain And Behavior ◽  
And Behavior

AbstractControllability over stressors has major impacts on brain and behavior. In humans, however, the effect of controllability on responses to stressors is poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated how controllability altered responses to a shock-plus-sound stressor with a between-group yoked design, where participants in controllable and uncontrollable groups experienced matched stressor exposure. Employing Bayesian multilevel analysis at the level of regions of interest and voxels in the insula, and standard voxelwise analysis, we found that controllability decreased stressor-related responses across threat-related regions, notably in the bed nucleus of the stria terminalis and anterior insula. Posterior cingulate cortex, posterior insula, and possibly medial frontal gyrus showed increased responses during control over stressor. Our findings support the idea that the aversiveness of stressors is reduced when controllable, leading to decreased responses across key regions involved in anxiety-related processing, even at the level of the extended amygdala.

Is There a Common Network for Processing Reward and Aversion in the Brain?

2016 ◽  
Author(s):  
Jiameng Xu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Prefrontal Cortex ◽  
Magnetic Resonance ◽  
Meta Analysis ◽  
Anterior Cingulate ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Aversive Stimuli ◽  
Midcingulate Cortex ◽  
The Brain

How do our brains process and attach positive and negative value to the objects around us, the sensations we feel, and the experiences that we have? One method of examining these questions is to detect, using functional magnetic resonance imaging (fMRI), which areas of the human brain are activated when subjects are exposed to rewarding and aversive stimuli. Although many fMRI studies have concentrated on identifying a network of areas that become active in processing either reward or aversion, there is evidence of significant overlap between the “reward” and “aversion” networks, suggesting that the brain might process rewarding and aversive stimuli in a similar manner regardless of valence. Thus, a meta-analysis of fMRI studies involving rewarding and aversive stimuli was undertaken to determine the areas of the brain that are commonly and differentially activated by reward and aversion. The preliminary results indicate that regions of the prefrontal cortex, anterior cingulate cortex, amygdala, nucleus accumbens, hippocampus, and basal ganglia were commonly activated by rewarding and aversive stimuli, while areas including the insula, midcingulate cortex, and parts of the hippocampus were differentially activated. Locating such commonalities and differences might help in our understanding of how the brain ascribes value to our environment.  

scholarly journals Pain and breathlessness: Salient, somatosensory and similar, but not the same

2020 ◽  
Author(s):  
Olivia K. Harrison ◽  
Anja Hayen ◽  
Tor D. Wager ◽  
Kyle T. S. Pattinson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Healthy Subjects ◽  
Pain Perception ◽  
Brain Activity ◽  
Anterior Cingulate ◽  
Self Report ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Posterior Insula ◽  
Insight Into

AbstractQuantifying pain currently relies upon subjective self-report. Alongside the inherent variability embedded within these metrics, added complications include the influence of ambiguous or prolonged noxious inputs, or in situations when communication may be compromised. As such, there is continued interest in the development of brain biomarkers of pain, such as in the form of neural ‘signatures’ of brain activity. However, issues pertaining to pain-related specificity remain, and by understanding the current limits of these signatures we can both progress their development and investigate the potentially generalizable properties of pain to other salient and/or somatomotor tasks. Here, we utilized two independent datasets to test one of the established Neural Pain Signatures (the NPS (Wager et al. 2013)). In Study 1, brain activity was measured using functional magnetic resonance imaging (fMRI) in 40 healthy subjects during experimentally induced breathlessness, conditioned anticipation of breathlessness and a simple finger opposition task. In Study 2, brain activity was again measured during anticipation and breathlessness in 19 healthy subjects, as well as a modulation with the opioid remifentanil. We were able to identify significant NPS-related brain activity during anticipation and perception of breathlessness, as well as during finger opposition using the global NPS. Furthermore, localised NPS responses were found in early somatomotor regions, bilateral insula and dorsal anterior cingulate for breathlessness and finger opposition. In contrast, no conditions were able to activate the local signature in the dorsal posterior insula - thought to be critical for pain perception. These results provide properties of the present boundaries of the NPS, and offer insight into the overlap between breathlessness and somatomotor conditions with pain.

scholarly journals Perceiving actions before they happen: psychological dimensions scaffold neural action prediction

2020 ◽  
Author(s):  
Mark A Thornton ◽  
Diana I Tamir
Keyword(s):  
Magnetic Resonance Imaging ◽  
Functional Neuroimaging ◽  
Social World ◽  
Action Space ◽  
Action Prediction ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
The Social ◽  
Psychological Dimensions ◽  
The Brain

Abstract The social world buzzes with action. People constantly walk, talk, eat, work, play, snooze and so on. To interact with others successfully, we need to both understand their current actions and predict their future actions. Here we used functional neuroimaging to test the hypothesis that people do both at the same time: when the brain perceives an action, it simultaneously encodes likely future actions. Specifically, we hypothesized that the brain represents perceived actions using a map that encodes which actions will occur next: the six-dimensional Abstraction, Creation, Tradition, Food(-relevance), Animacy and Spiritualism Taxonomy (ACT-FAST) action space. Within this space, the closer two actions are, the more likely they are to precede or follow each other. To test this hypothesis, participants watched a video featuring naturalistic sequences of actions while undergoing functional magnetic resonance imaging (fMRI) scanning. We first use a decoding model to demonstrate that the brain uses ACT-FAST to represent current actions. We then successfully predicted as-yet unseen actions, up to three actions into the future, based on their proximity to the current action’s coordinates in ACT-FAST space. This finding suggests that the brain represents actions using a six-dimensional action space that gives people an automatic glimpse of future actions.

scholarly journals Integrating additional knowledge into the estimation of graphical models

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Yunqi Bu ◽  
Johannes Lederer
Keyword(s):  
Graphical Models ◽  
Tuning Parameter ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Graphical Modeling ◽  
Standard Methods ◽  
Neighborhood Selection ◽  
Selection For ◽  
The Brain

Abstract Graphical models such as brain connectomes derived from functional magnetic resonance imaging (fMRI) data are considered a prime gateway to understanding network-type processes. We show, however, that standard methods for graphical modeling can fail to provide accurate graph recovery even with optimal tuning and large sample sizes. We attempt to solve this problem by leveraging information that is often readily available in practice but neglected, such as the spatial positions of the measurements. This information is incorporated into the tuning parameter of neighborhood selection, for example, in the form of pairwise distances. Our approach is computationally convenient and efficient, carries a clear Bayesian interpretation, and improves standard methods in terms of statistical stability. Applied to data about Alzheimer’s disease, our approach allows us to highlight the central role of lobes in the connectivity structure of the brain and to identify an increased connectivity within the cerebellum for Alzheimer’s patients compared to other subjects.

scholarly journals Adaptive brain activity changes during tongue movement with palatal coverage from fMRI data

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuka Inamochi ◽  
Kenji Fueki ◽  
Nobuo Usui ◽  
Masato Taira ◽  
Noriyuki Wakabayashi
Keyword(s):  
Spatial Information ◽  
Brain Activity ◽  
Motor Impairment ◽  
Angular Gyrus ◽  
Tongue Movement ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Oral Environment ◽  
Motor Dexterity ◽  
The Brain

AbstractSuccessful adaptation to wearing dentures with palatal coverage may be associated with cortical activity changes related to tongue motor control. The purpose was to investigate the brain activity changes during tongue movement in response to a new oral environment. Twenty-eight fully dentate subjects (mean age: 28.6-years-old) who had no experience with removable dentures wore experimental palatal plates for 7 days. We measured tongue motor dexterity, difficulty with tongue movement, and brain activity using functional magnetic resonance imaging during tongue movement at pre-insertion (Day 0), as well as immediately (Day 1), 3 days (Day 3), and 7 days (Day 7) post-insertion. Difficulty with tongue movement was significantly higher on Day 1 than on Days 0, 3, and 7. In the subtraction analysis of brain activity across each day, activations in the angular gyrus and right precuneus on Day 1 were significantly higher than on Day 7. Tongue motor impairment induced activation of the angular gyrus, which was associated with monitoring of the tongue’s spatial information, as well as the activation of the precuneus, which was associated with constructing the tongue motor imagery. As the tongue regained the smoothness in its motor functions, the activation of the angular gyrus and precuneus decreased.

scholarly journals Talent in the taxi: a model system for exploring expertise

2009 ◽  
Vol 364 (1522) ◽  
pp. 1407-1416 ◽  
Author(s):  
Katherine Woollett ◽  
Hugo J. Spiers ◽  
Eleanor A. Maguire
Keyword(s):  
Model System ◽  
Neural Mechanisms ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Taxi Drivers ◽  
The Brain ◽  
Use Of Expertise ◽  
Widespread Interest ◽  
Key Questions ◽  
Extensive Practice

While there is widespread interest in and admiration of individuals with exceptional talents, surprisingly little is known about the cognitive and neural mechanisms underpinning talent, and indeed how talent relates to expertise. Because many talents are first identified and nurtured in childhood, it can be difficult to determine whether talent is innate, can be acquired through extensive practice or can only be acquired in the presence of the developing brain. We sought to address some of these issues by studying healthy adults who acquired expertise in adulthood. We focused on the domain of memory and used licensed London taxi drivers as a model system. Taxi drivers have to learn the layout of 25 000 streets in London and the locations of thousands of places of interest, and pass stringent examinations in order to obtain an operating licence. Using neuropsychological assessment and structural and functional magnetic resonance imaging, we addressed a range of key questions: in the context of a fully developed brain and an average IQ, can people acquire expertise to an exceptional level; what are the neural signatures, both structural and functional, associated with the use of expertise; does expertise change the brain compared with unskilled control participants; does it confer any cognitive advantages, and similarly, does it come at a cost to other functions? By studying retired taxi drivers, we also consider what happens to their brains and behaviour when experts stop using their skill. Finally, we discuss how the expertise of taxi drivers might relate to the issue of talent and innate abilities. We suggest that exploring talent and expertise in this manner could have implications for education, rehabilitation of patients with cognitive impairments, understanding individual differences and possibly conditions such as autism where exceptional abilities can be a feature.

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