scholarly journals Study on repairing canine mandibular defect with porous Mg–Sr alloy combined with Mg–Sr alloy membrane

2020 ◽  
Vol 7 (3) ◽  
pp. 331-336
Author(s):  
Shanning Zhang ◽  
Xirao Sun ◽  
Chunyu Kang ◽  
Man Yang ◽  
Yuan Zhao ◽  
...  
Keyword(s):  
Volume Fraction ◽  
Bone Defects ◽  
Collagen Membrane ◽  
Bone Volume Fraction ◽  
Tomographic Images ◽  
Computed Tomographic ◽  
Membrane Bone ◽  
Group A ◽  
Mandibular Defect ◽  
Group B

Abstract To discuss the feasibility of the application of porous Mg–Sr alloy combined with Mg–Sr alloy membrane in the repair of mandibular defects in dogs. The second and third mandibular premolars on both sides were extracted from six dogs. The model of mandible buccal fenestration bone defects were prepared after the sockets healed. Twelve bone defects were randomly divided into groups A and B, then Mg–Sr alloy was implanted in bone defects of group A and covered by Mg–Sr alloy membrane while Mg–Sr alloy was implanted in bone defects of group B and covered by mineralized collagen membrane. Bone defects observed on cone beam computed tomographic images and comparing the gray value of the two groups after 4, 8 and 12 weeks. After 12 weeks, the healing of bone defects were evaluated by gross observation, X-ray microscopes and histological observation of hard tissue. Bone defects in each group were repaired. At 8 and 12 weeks, the gray value of group A was higher than that of group B (P < 0.05). At 12 weeks, the bone volume fraction of group A was higher than that of group B (P < 0.05). The newly woven bone in group A is thick and arranged staggered, which was better than that of group B. Porous Mg–Sr alloy combined with Mg–Sr alloy membrane could further promote the repair of mandibular defects, and obtain good osteogenic effect.

Repairing Rabbit Radius Bone Defects with Simvastatin Compound Biological Bone

2021 ◽  
Vol 11 (7) ◽  
pp. 1263-1270
Author(s):  
Zhong-Yu Liu ◽  
Jin-Li Zhang ◽  
Yang Zhang ◽  
Shi-Lian Kan ◽  
Jun Liang ◽  
...  
Keyword(s):  
Bone Defect ◽  
Maximum Stress ◽  
Biomechanical Testing ◽  
Bone Defects ◽  
Bending Test ◽  
Bone Material ◽  
X Ray ◽  
Group A ◽  
Group B ◽  
Group D

Objective: This study aimed to investigate the feasibility of repairing rabbit radius bone defects with simvastatin compound biological bone. Methods: Simvastatin biological bone material was prepared, and osteoblasts were cultured. A total of 42 New Zealand white rabbits were randomly divided into four groups, and a bone defect with a length of 15 mm was created at the middle part of the radial shaft of both limbs in each rabbit, thereby establishing a bone defect model. The grafts in group A were biological bones of osteoblasts combined with simvastatin; the grafts in group B were biological bones of simvastatin; the grafts in group C were biological compound bones of osteoblasts; and the grafts in group D were simple biological bones. In each group, four animals were randomly sacrificed at the sixth and twelfth week after surgery, and specimens were collected for gross observation, X-ray examination, histological observation, and biomechanical testing. In each group, two animals were randomly sacrificed at the twelfth week after surgery; a three-point bending test was performed using a biomechanical testing machine, and the results were compared with those of a normal radius. Results: The X-ray and histological examinations at 6 and 12 weeks after surgery revealed that the osteogenesis ability of the simvastatin biological bone and osteoblast-simvastatin biological bone was better than that of the osteoblast biological bone and simple biological bone, which was superior in group A and group B to group C and group D. The results of the biomechanical examination revealed that the maximum stress of the normal radius was significantly higher than that of the experimental groups. Among the experimental groups, the difference between group A and group B was not statistically significant, and the maximum stress was higher in groups A and B than in groups C and D. Conclusion: Simvastatin biological bone material can promote the repair of rabbit radius defects and increase the quality of bone healing.

Gallium scans in the evaluation of residual masses after chemotherapy for seminoma.

1995 ◽  
Vol 13 (11) ◽  
pp. 2784-2788 ◽  
Author(s):  
G P Warren ◽  
L H Einhorn
Keyword(s):  
False Negative ◽  
Fibrous Tissue ◽  
Salvage Chemotherapy ◽  
First Line ◽  
Chemotherapy Group ◽  
Computed Tomographic ◽  
Group A ◽  
Residual Masses ◽  
Group B

PURPOSE To assess the ability of gallium scans to determine whether residual masses consist of viable tumor or necrotic fibrous tissue after chemotherapy for seminoma. PATIENTS AND METHODS Thirty-two patients were enrolled and 27 were assessable. Patients receiving first-line or salvage chemotherapy had gallium scans performed during their first and last scheduled course of chemotherapy and results were compared with restaging computed tomographic (CT) scans and subsequent clinical outcome. RESULTS Of 27 assessable patients, 22 received first-line chemotherapy (group A) and five salvage chemotherapy (group B). Eight patients were not gallium-avid before chemotherapy despite obvious clinical and radiographic evidence of metastatic seminoma. Eighteen of 19 gallium-positive patients had a persistent mass postchemotherapy on abdominal CT. Of 16 patients in group A whose tumors were gallium-avid, all 16 had normalized gallium scans after chemotherapy. However, two of these 16 patients recurred in their original disease site. In group B, there were three patients with gallium-avid tumors and all three had normalized scans postchemotherapy. Two patients who were not gallium-avid (one each in group A and B) also developed recurrent disease. Twenty-four of 27 patients are alive with no evidence of active disease at a median follow-up time of 18 months, including 20 with more than 1 year of follow-up data. CONCLUSION Eight of 27 patients had false-negative gallium scans at the time of diagnosis. All nineteen gallium scans that were initially positive reverted to normal after chemotherapy. Two of 19 patients' follow-up gallium scans were false-negative. We therefore feel that gallium scans have minimal value in the prechemotherapy or postchemotherapy evaluation of metastatic seminoma.

COMPARATIVE STUDY OF DECOMPRESSIVE CRANIECTOMY AFTER MASS LESION EVACUATION IN SEVERE HEAD INJURY

Neurosurgery ◽  
2009 ◽  
Vol 64 (5) ◽  
pp. 927-940 ◽  
Author(s):  
Bizhan Aarabi ◽  
Dale C. Hesdorffer ◽  
J. Marc Simard ◽  
Edward S. Ahn ◽  
Carla Aresco ◽  
...  
Keyword(s):  
Head Injury ◽  
Glasgow Coma Scale ◽  
Decompressive Craniectomy ◽  
Mass Lesion ◽  
Icp Monitoring ◽  
Computed Tomographic ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Mass Evacuation

Abstract OBJECTIVE This study was conducted to evaluate outcome after decompressive craniectomy (DC) in the setting of mass evacuation with or without intracranial pressure (ICP) monitoring. METHODS Over a 48-month period (March 2000 to March 2004), 54 of 967 consecutive head injury patients underwent DC for evacuation of a mass lesion. DC was performed without ICP monitoring in 27 patients who required urgent decompression (group A) and in 27 patients who did not require urgent surgery and who had their ICP monitored for 1 to 14 days before surgery (group B). RESULTS In group A, the mean Glasgow Coma Scale score was 6.0; 80% had computed tomographic evidence of a shift greater than 5 mm; and 25 patients underwent DC immediately after resuscitation. In group B, the mean Glasgow Coma Scale score was 7.3; 40% had computed tomographic evidence of shift; and 75% underwent DC 24 hours or longer after presentation. Overall, 22 patients died (12 in group A and 10 in group B), 11 remained vegetative or severely disabled (3 in group A and 8 in group B), and 19 had good recovery (11 in group A and 8 in group B). Two patients were lost to follow-up. In 18 group B patients with ICP greater than 20 mm Hg before mass evacuation, ICP dropped an average of 13 mm Hg (P < 0.001). A mass lesion greater than 50 mL (odds ratio [OR], 2.86; 95% confidence interval [CI], 1.04–7.89) and evidence of low attenuation on computed tomography before (OR, 3.3; 95% CI, 1.1–10.3) or after (OR, 2.92; 95% CI, 1.02–8.34) DC were predictors of death. A good outcome occurred in 42% of patients with and in 63% of patients without delayed traumatic injury (OR, 0.3; 95% CI, 0.1–1.1). Outcome was favorable in 78.6% of patients who had no ICP monitoring before DC versus 47.1% of patients with ICP monitoring (OR, 0.2; 95% CI, 0.1–1.2). CONCLUSION In this study, mortality after DC for mass lesion was greater than expected, and outcome did not differ between patients with or without ICP monitoring.

Combined Encephaloduroarteriosynangiosis and Bifrontal Encephalogaleo(periosteal)synangiosis in Pediatric Moyamoya Disease

Neurosurgery ◽  
2002 ◽  
Vol 50 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Seung-Ki Kim ◽  
Kyu-Chang Wang ◽  
In-One Kim ◽  
Dong Soo Lee ◽  
Byung-Kyu Cho
Keyword(s):  
Moyamoya Disease ◽  
Cerebral Artery ◽  
Anterior Cerebral Artery ◽  
Single Photon ◽  
Photon Emission ◽  
Single Photon Emission ◽  
Computed Tomographic ◽  
Group A ◽  
Single Photon Emission Computed ◽  
Group B

ABSTRACT OBJECTIVE We compared the surgical results of simple encephaloduroarteriosynangiosis (EDAS) and EDAS with bifrontal encephalogaleo(periosteal)synangiosis for the treatment of pediatric moyamoya disease. METHODS Data for 159 children (up to 15 yr of age, 76 boys and 83 girls) who underwent indirect revascularization procedures for the treatment of moyamoya disease between 1987 and 1998 were retrospectively reviewed. Group A patients underwent simple EDAS (n = 67). Group B patients underwent EDAS with bifrontal encephalogaleo(periosteal)synangiosis (n = 92). The surgical results for each group were compared, in terms of clinical outcomes, neuroimaging changes, extent of revascularization evident on angiograms, and hemodynamic changes evident on single-photon emission computed tomographic scans. The average follow-up periods were 45 months for Group A and 22 months for Group B. RESULTS The overall clinical outcomes and neuroimaging changes tended to be better for Group B. In terms of single-photon emission computed tomographic changes of the whole brain after surgery, Group B patients exhibited more favorable outcomes than did Group A patients (62 versus 36%, P = 0.003). The surgical results for the anterior cerebral artery territory were significantly better for Group B than for Group A, with respect to outcomes of anterior cerebral artery symptoms (81 versus 40%, P = 0.015), revascularization on angiograms (79 versus 16%, P < 0.001), and hemodynamic changes on single-photon emission computed tomographic scans (70 versus 52%, P = 0.002). The incidences of postoperative infarctions were not significantly different between the two groups. CONCLUSION EDAS with bifrontal encephalogaleo(periosteal)synangiosis is a more effective surgical modality for the treatment of pediatric moyamoya disease, compared with simple EDAS, because it covers both the middle cerebral artery and anterior cerebral artery territories of the brain.

scholarly journals Axial Vascularization of Nano-HA/Collagen/PLA Composites by Arteriovenous Bundle

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hai Wang ◽  
Xiao Chang ◽  
Guixing Qiu ◽  
Fuzhai Cui ◽  
Xisheng Weng ◽  
...  
Keyword(s):  
Autologous Bone Marrow ◽  
Bone Defects ◽  
Phase 2 ◽  
Large Defect ◽  
Group A ◽  
Group B ◽  
Axial Vascularization ◽  
Vascularized Bone ◽  
Av Bundle ◽  
Sufficient Oxygen

In previous studies, nano-hydroxyapatite/collagen/poly(L-lactic acid) (nHAC/PLA) composites have been prepared and confirmed to repair small sized bone defects. However, they are restricted to repair a large defect without sufficient oxygen and nutrition for cell survival. The result of this study confirmed that nHAC/PLA composites could be axially vascularized by being implanted intramuscularly with arteriovenous (AV) bundle (Group A) in the groins of rabbits. The combination with autologous bone marrow (Group B) could not enhance it the vascularization in early phase (2 weeks,P>0.05), but it could enhance in middle and later phases (6 and 10 weeks,P<0.01). It meant that nHAC/PLA could be prefabricated as a vascularized bone substitute for grafting.

Comparison of Virtual and Conventional Endoscopy of Nose and Paranasal Sinuses

2003 ◽  
Vol 112 (2) ◽  
pp. 139-142 ◽  
Author(s):  
Lino Di Rienzo ◽  
Guido Coen Tirelli ◽  
Francesco Garaci ◽  
Piergiorgio Turchio ◽  
Marco Guazzaroni
Keyword(s):  
Paranasal Sinuses ◽  
Nasal Fossa ◽  
Noninvasive Technique ◽  
Computed Tomographic ◽  
Fiberoptic Endoscopy ◽  
Sinus Cavity ◽  
History Of ◽  
Group A ◽  
Nose And Paranasal Sinuses ◽  
Group B

We compared computed tomographic virtual rhinosinus endoscopy (VRS) and conventional fiberoptic endoscopy (FE) for the detection of inflammatory-obstructive rhinosinusal disease. We recruited 158 patients; 100 (group A) had inflammatory-obstructive rhinosinus disease, and 58 (group B) had a history of rhinosinus surgery. All patients underwent VRS within 2 to 6 hours of FE, and VRS was able to demonstrate the anatomic details of the nasal fossa and rhinopharynx with a high correspondence to FE. A satisfying representation of anatomic detail was found in both groups A and B. The VRS was able to visualize invasiveness of the endosinusal cavities, which was not accessible to FE. The VRS is a fast, relatively easy, and noninvasive technique that could be integrated into FE or used as an alternative when FE is unfeasible. Because of the ability to explore the sinus cavity, we suggest that virtual rhinosinusoscopy should be considered as the appropriate term, instead of virtual rhinoscopy.

scholarly journals Novel piston technique versus Ilizarov technique for the repair of bone defect after lower limb infection

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jiafei Du ◽  
Zifei Yin ◽  
Pengfei Cheng ◽  
Pei Han ◽  
Hao Shen
Keyword(s):  
Bone Healing ◽  
Lower Limb ◽  
Joint Stiffness ◽  
Functional Results ◽  
Bone Defects ◽  
Ilizarov Technique ◽  
Group A ◽  
The Mean ◽  
Group B

Abstract Background We aimed to compare the effectiveness and complications of a novel piston technique versus the Ilizarov technique for the repair of bone defects after lower limb infection. Patients and methods We retrospectively reviewed 41 patients who had been treated at our department for lower extremity bone defects following osteomyelitis. There were 38 men and three women with a mean age of 43.41 (range, 12–69 years). The infected bone defects involved 36 tibias and five femurs. The piston technique (PT, group A) was used in 12 patients and the Ilizarov technique (IT, group B) in 29 patients. The mean follow-up period was 28.50 months (PT) and 29.90 months (IT). The modified Application of Methods of Illizarov (ASAMI) criteria was used to evaluate bone healing and functional recovery. Results Complete eradication of the infection and union of docking sites were accomplished in both groups. The mean external fixator index (EFI) was 42.32 days/cm in group A versus 58.85 days/cm in group B (p < 0.001). The bone outcomes were similar between groups A and B (p = 0.558) (excellent [9 vs. 19], good [3 vs.10]); group A showed better functional outcomes than group B (p < 0.05) (excellent [7 vs. 6], good [4 vs. 12], fair [0 vs. 10] and poor [1 vs. 1]). Pain was the most common complaint during follow-up, and group A had fewer cases of pin tract infection (1 vs. 6), adjacent joint stiffness (3 vs. 8), and delayed healing of the joint (0 vs. 3). Conclusions Satisfactory bone healing can be achieved by using both PT and IT, although PT demonstrated better functional results, lower EFI, and allowed early removal of the external fixation. We found that this novel piston technique can improve the comfort of patients, reduce the incidence of complications, and provide rapid and convenient rehabilitation.

scholarly journals Classification and morphology of middle mesial canals of mandibular first molars in a Southern Chinese subpopulation: a cone-beam computed tomographic study

2020 ◽  
Author(s):  
Yeqing Yang ◽  
Ming Chen ◽  
Junkai Zeng ◽  
Buling Wu
Keyword(s):  
Incidence Rate ◽  
Root Canal ◽  
Cone Beam ◽  
Inclusion Criteria ◽  
Canal System ◽  
Computed Tomographic ◽  
Southern Chinese ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Background：Cone-beam computed tomography (CBCT) was used to study the morphology and curvature of the middle mesial canals (MMCs) of the mandibular first molars (MFMs).Methods：CBCT scanning was performed on the MFMs of 1100 patients. The pa tients' images which met the inclusion criteria were divided into group A (<40 years old) and group B (≥40 years old) for further study. To study the incidence of the MMCs at different ages, to measure the curvature of MMCs of mesiodistal and buccolingual direction by Schneider method, and to observe the anatomical morphology of the mesial root canal system.Results：In 875 patients, 1750 MFM images met the inclusion criteria, among which 158 MFMs contained a MMC, with an incidence rate of 9.03%. The incidence rate of MMCs was 11.22% in group A and 6.61% in group B, with statistically significant differences (P<0.05). The curvature in group A was 29.39±8.53° in mesiodistal direction while group B was 26.06±8.50 °, with statistical differences (P＜0.05). It has been shown that curved regions in group A and B were often found out in the middle 1/3. There is no significant difference in the distance between MMC orifices and mesiobuccal canal orifices or mesiolingual canal orifices (P>0.05). The most common mesial root canal morphology type was type II (3-2) (53.80%). Conclusion：The incidence of MMCs in MFMs was showed to decline along with the increase of age. The canal system of MMCs was varied and complex, mostly with mesiodistal curve obviously. CBCT is an outstanding assistant examination to the root canal therapy.

scholarly journals Results of the Study of Bone Tissue Density in Patients of the Study Groups at the Restoration of Bone Defects by Various Osteoplastic Materials

2021 ◽  
Vol 6 (2) ◽  
pp. 158-162
Author(s):  
A. V. Bambuliak ◽  
◽  
N. B. Kuzniak ◽  
R. R. Dmitrenko ◽  
S. V. Tkachik ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Density ◽  
Bone Tissue ◽  
Bone Defect ◽  
Maxillofacial Surgery ◽  
Bone Defects ◽  
X Ray ◽  
Group A ◽  
X Ray Computed ◽  
Group B

The restoration processes of damaged or lost bone tissue are an important and topical issue of surgical dentistry and maxillofacial surgery today. According to statistics, diseases that are accompaning by destructive changes in bone tissue occupy one of the dominant places among the nosologies of MFA. Along with the use of updated methods of surgical technique, both before and now the problem of choice of bone-plastic material is relevant, because it is known that osteoplasty opens up great opportunities for complete rehabilitation of patients. The purpose of the study was to determine the effectiveness of our developed osteoplastic composition for the restoration of bone defects in dentistry. Materials and methods. X-ray computed tomography to determine bone density was performed in 26 patients with bone defect replacement "Kolapan-L" (group A), 28 people during augmentation of our proposed osteoplastic composition "Kolapan-L" + multipotent mesenchymal stromal cells + platelet-rich plasma) (group B), and 25 patients where the healing of the bone defect occurred spontaneously (group B). X-ray computed tomography was performed on a 16-slice spiral computed tomography Siemens Somatom Emotionc. Image processing was performed using the program "Dicom". Statistical processing of research results was carried out using conventional methods of variation statistics. Results and discussion. After 1 year of research, the average value of the bone density in patients of group B was probably higher: 1.5 times and 1.8 times relative to the corresponding data in groups A and B. At the same time, the minimum value of the bone density in patients of subgroups A and B was 1.5 times and 1.8 times lower than in persons of group B (p <0.01, p1 <0.01). At the same time, the maximum values of the bone density in patients of group B, where the augmentation of bone defects was performed using our proposed composition, were 1.4 times (p <0.01) and 1.8 times (p <0.05, p1 <0.01) higher than in group A, in the replacement of bone defects "Kolapan-L" and in group B, where the healing of the bone defect was spontaneous, respectively. It was found that in patients of group B after 12 months of studies, the average density of osteoregeneration was 1036.69±55.53 (HU), which was 1.5 times and 1.8 times more than in group A (p <0.01) and in group B patients (p <0.05, p1 <0.01) respectively. Conclusion. The use of tissue equivalent of bone tissue, proposed by us to replace a bone defect based on multipotent mesenchymal adipose tissue cells, contributed to the maximum increase in bone density, with a slightly lower effect of increasing bone density in the augmentation of bone defects

scholarly journals Comparative Study on the Application of Mesenchymal Stromal Cells Combined with Tricalcium Phosphate Scaffold into Femoral Bone Defects

2018 ◽  
Vol 27 (10) ◽  
pp. 1459-1468 ◽  
Author(s):  
Pavel Šponer ◽  
Tomáš Kučera ◽  
Jindra Brtková ◽  
Karel Urban ◽  
Zuzana Kočí ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Control Group ◽  
Graft Material ◽  
Synthetic Graft ◽  
Group A ◽  
Group B ◽  
And Control

This prospective study sought to evaluate the healing quality of implanted ultraporous β-tricalcium phosphate sown with expanded autologous mesenchymal stromal cells (MSCs) into femoral defects during revision hip arthroplasty. A total of 37 osseous defects in 37 patients were treated and evaluated concerning bone regeneration. Nineteen subjects received β-tricalcium phosphate graft material serving as a carrier of expanded autologous MSCs (the trial group A), nine subjects received β-tricalcium phosphate graft material only (the study group B) and nine subjects received cancellous allografts only (the control group C). Clinical and radiographic evaluations were scheduled at 6 weeks, 3, 6, and 12 months post-operatively, and performed at the most recent visit as well. All observed complications were recorded during follow-up to assess the use of an ultraporous β-tricalcium phosphate synthetic graft material combined with expanded MSCs in bone defect repair. The resulting data from participants with accomplished follow-up were processed and statistically evaluated with a Freeman–Halton modification of the Fischer’s exact test, a P < 0.05 value was considered to be significant. Whereas no significant difference was observed between the trial group A with β-tricalcium phosphate synthetic graft material serving as a carrier of expanded autologous MSCs and control group C with cancellous impaction allografting in terms of the bone defect healing, significant differences were documented between the study group B with β-tricalcium phosphate graft material only and control group C. Regarding adverse effects, six serious events were recorded during the clinical trial with no causal relationship to the cell product. β-tricalcium phosphate synthetic graft material serving as a carrier of expanded autologous MSCs appears safe and promotes the healing of bone defects in a jeopardized and/or impaired microenvironment. This clinical trial was registered at the EU Clinical Trials Register before patient recruitment (Registration number: EudraCT number 2012-005599-33; Date of registration: 2013-02-04).

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