scholarly journals Loading necrostatin-1 composite bone cement inhibits necroptosis of bone tissue in rabbit

2019 ◽  
Vol 6 (2) ◽  
pp. 113-119 ◽  
Author(s):  
Xiang Ji ◽  
Feng Xu ◽  
Guoling Dong ◽  
Chongzhe Jia ◽  
Pu Jia ◽  
...  
Keyword(s):  
Bone Cement ◽  
Bone Tissue ◽  
Composite Bone

scholarly journals Comparative evaluation of polymethylmethacrylate and composite bone cements. Review of the experimental studies results

2021 ◽  
pp. 86-91
Author(s):  
Oleg Vyrva ◽  
Olexii Goncharuk ◽  
Natalia Lysenko
Keyword(s):  
Bone Cement ◽  
Bone Tissue ◽  
Experimental Studies ◽  
Bone Cements ◽  
Main Task ◽  
Composite Cement ◽  
Bone Fragments ◽  
Intensive Work ◽  
Composite Bone

Current article is a review of experimental studies of different bone cements types and their combinations. Providing of bone fragments  stable fixation  at osteosynthesis  in cases of difficult multifragmental fractures, arthroplasties and other implants using especially in the osteoporosis conditions is a main task of orthopaedic surgery procedures. Polymethylmethacrylate (PMMA) is the first material that is answered to these requirements. The evolution of bone cements resulted in creation of a new composite substance — combination of PMMA and β-threecalciumphosfates (β-TCPh). Combination of these two components allowed to provide high bioabsorbal, osteoconductive and osteointegrative properties along with sufficient durability. In the analyzed works the properties of composite cement CalCemex were evaluated in vivo experiment. It was found that in the case of PMMA penetration of bone tissue into the polymer structure did not occur. Under the conditions of using bone cement with β-TCF admixture, the formation of bone tissue was observed not only on the surface of the implant, but also in the external and internal pores. It is the presence of pores in CalCemex that the authors explain the possibility of penetration of cellular elements, blood vessels and bone formation. Moreover, β-TCPh is included into this material and it is bioresorbed by osteoclasts. This leads to the release of calcium and phosphorus ions and, consequently, simplifies the attachment of the newly formed bone to the bone cement. We assume that composite cement like CalCemex type is a promising material for the treatment of various types of fractures and replacement of bone defects. It should be mentioned that research in this area is ongoing and intensive work is underway to synthesize and study the results of clinical application of composite bone cements with maximum bioactive properties that will not only strengthen bone tissue but also perform osteointegrative function. Key words. Bone cement, polymethylmethacrylate, β-threecalciumphosfates, experiment.

scholarly journals Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Che Nor Zarida Che Seman ◽  
Zamzuri Zakaria ◽  
Zunariah Buyong ◽  
Mohd Shukrimi Awang ◽  
Ahmad Razali Md Ralib @ Md Raghib
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Tissue ◽  
Bone Repair ◽  
Critical Size ◽  
Healing Process ◽  
Bone Defects ◽  
Calcium Phosphate Bone Cement ◽  
Rabbit Tibia

Introduction: A novel injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tricalcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could be a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

Preparation and in vivo evaluation of a silicate-based composite bone cement

2017 ◽  
Vol 32 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Bing Ma ◽  
Zhiguang Huan ◽  
Chen Xu ◽  
Nan Ma ◽  
Haibo Zhu ◽  
...  
Keyword(s):  
Bone Cement ◽  
In Vivo Evaluation ◽  
Composite Bone

scholarly journals Controlled release properties and final macroporosity of a pectin microspheres–calcium phosphate composite bone cement

2010 ◽  
Vol 6 (6) ◽  
pp. 2294-2300 ◽  
Author(s):  
S. Girod Fullana ◽  
H. Ternet ◽  
M. Freche ◽  
J.L. Lacout ◽  
F. Rodriguez
Keyword(s):  
Controlled Release ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Composite Bone

The structural changes in the bone tissue and regional lymph nodes when using bone cement

2017 ◽  
Author(s):  
D. V. Zhukov ◽  
A. M. Zajdman ◽  
V. M. Prohorenko ◽  
N. V. Ustikova
Keyword(s):  
Lymph Nodes ◽  
Bone Cement ◽  
Bone Tissue ◽  
Structural Changes ◽  
Regional Lymph Nodes

scholarly journals A promising material for bone repair: PMMA bone cement modified by dopamine-coated strontium-doped calcium polyphosphate particles

2019 ◽  
Vol 6 (10) ◽  
pp. 191028 ◽  
Author(s):  
Xing Liu ◽  
Can Cheng ◽  
Xu Peng ◽  
Hong Xiao ◽  
Chengrui Guo ◽  
...  
Keyword(s):  
Bone Cement ◽  
Bone Repair ◽  
Bone Cements ◽  
The Novel ◽  
Calcium Polyphosphate ◽  
Pmma Bone Cement ◽  
Repair Materials ◽  
Biological Performance ◽  
Bone Repair Materials ◽  
Composite Bone

Polymethyl methacrylate (PMMA) bone cement has been widely used in clinics as bone repair materials for its excellent mechanical properties and good injection properties. However, it also has defects such as poor biological performance, high temperature, and the monomer has certain toxicity. Our study tried to modify the PMMA bone cement by doping with various particle weight fractions (5, 10 and 15%) of SCPP particles and polydopamine-coated SCPP particles (D/SCPP) to overcome its clinical application disadvantages. Our study showed that all results of physical properties of samples are in accordance with ISO 5833. The 15% D/SCPP/PMMA composite bone cement had much better biocompatibility compared with pure PMMA bone cement and SCPP/PMMA composite bone cement due to the best cell growth-promoting mineralization deposition on the surface of 15% D/SCPP/PMMA composite bone cements and Sr 2+ released from SCPP particles. Our research also revealed that the reaction temperature was found to be reduced with an increase in doped particles after incorporating the particles into composite bone cements. The novel PMMA bone cements modified by D/SCPP particles are promising materials for bone repair.

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