scholarly journals Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors

2020 ◽  
Vol 7 (6) ◽  
pp. 567-575
Author(s):  
Chong Gao ◽  
Zhi-Ye Qiu ◽  
Jian-Wen Hou ◽  
Wei Tian ◽  
Jian-Ming Kou ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Grafting ◽  
Bone Tumors ◽  
Statistical Difference ◽  
Bone Matrix ◽  
Autogenous Bone ◽  
Allogeneic Bone ◽  
Musculoskeletal Tumor Society ◽  
Benign Bone Tumors ◽  
Mineralized Collagen

Abstract Curettage of benign bone tumor is a common cause for bone defect. For such bone defect repair, autogenous bone, allogeneic bone and traditional artificial bone graft substitutes have many disadvantages. In recent years, a biomimetic mineralized collagen (MC) with similar composition and microstructures to the natural bone matrix was developed and used for treating various bone defects. In this work, a retrospective study analyzed clinical outcomes of patients treated with curettage of benign bone tumors and bone grafting with MC, in comparison to another group treated with the same surgical method and autogenous bone. Lane–Sandhu X-ray score of the autogenous bone group was superior to the MC group at 1 month after the operation, but the two groups had no statistical difference at 6 and 12 months. The MC group was better in Musculoskeletal Tumor Society scoring at 1 and 6 months after the operation, and the two groups had no statistical difference at 12 month. Therefore, the MC performed not as good as autogenous bone in early stage of bone healing but achieved comparable outcomes in long-term follow-ups. Moreover, the MC has advantages in function recovery and avoided potential complications induced by harvesting autogenous bone.

scholarly journals Histopathological and Radiographical Evaluation of Caprine Demineralized Bone Matrix in a Critical Ulnar Defect in a Rabbit Model

2021 ◽  
Author(s):  
Olawale Alimi Alimi ◽  
Adamu Abdul Abuabakar ◽  
Abubakar Sadiq Yakubu ◽  
Sani Abdullahi Shehu ◽  
Salman Zubairu Abdulkadir
Keyword(s):  
Bone Defect ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Rabbit Model ◽  
Negative Control ◽  
Autogenous Bone ◽  
Level Of Evidence ◽  
Defect Sites ◽  
Significant Difference ◽  
Demineralized Bone

Abstract Background: Caprine species satisfy the conditions of an ideal donor animal when compared to bovine species that has been extensively studied and commercialized for bone xenograft. Histopathological and radiological evaluations of caprine demineralized bone matrix (CDBM) were therefore carried out for fracture healing properties for its possible use in bone grafting procedures. Materials and Methods: Twenty-four rabbits were used for this study and were divided randomly into three groups of eight (n=8) rabbits each. Critical bone defect was created on the ulnar diaphysis under xylazine-ketamine anaesthesia for autogenous bone graft (ABG) group, CDBM group and the last group was left unfilled as negative control (NC). Immediate post-grafting radiograph was taken and repeated on days 14, 28, 42 and 56 to monitor the evidence of radiographic healing. The animals were euthanized on day 56 and defect sites were harvested for histopathology. Results: There was a progressive evidence of radiographic healing and bone formation in all the groups with significance difference (P=0.0064). When compared with ABG, NC differ significantly (P<0.0001) whereas the CDBM did not differ significantly (P=0.6765). The histopathology sections of ABG and CDBM showed normal bone tissue while the NC section was predominated by fibrous connective tissue. There was therefore an overall significant difference (P=0.0001) in which CDBM did not differ from ABG (P=0.2946) while NC did (P=0.0005). Conclusion: The ABG and CDBM groups showed a similar healing effect in the critical bone defect. Therefore, CDBM could be used as an effective alternative to ABG in orthopaedics to circumvent the limitations and complications associated with it. Level of Evidence: Not applicable.

scholarly journals Reconstruction of alveolar cleft with allogenous bone graft: clinical considerations

2013 ◽  
Vol 18 (6) ◽  
pp. 138-147 ◽  
Author(s):  
Omar Gabriel da Silva Filho ◽  
Terumi Okada Ozawa ◽  
Cláudia Bachega ◽  
Marco Aurélio Bachega
Keyword(s):  
Bone Grafting ◽  
Iliac Crest ◽  
Mixed Dentition ◽  
Autogenous Bone ◽  
Allogeneic Bone ◽  
Routine Procedure ◽  
Bone Bank ◽  
Alveolar Cleft ◽  
Autogenous Bone Grafting ◽  
Clinical Considerations

INTRODUCTION: Secondary bone grafting consists in a routine procedure on the treatment of patients with alveolar cleft. Usually, it is performed by the end of the mixed dentition, when the permanent canine is erupting, with autogenous cancellous bone from the iliac crest. OBJECTIVE: The present article discusses the alternative of autogenous bone grafting with allogeneic bone, obtained from human bone bank, illustrating the result with the presentation of a clinical case of left unilateral alveolar cleft.

scholarly journals Immunogenicity of Bone Graft Using Xenograft Freeze-Dried Cortical Bovine, Allograft Freeze-Dried Cortical New Zealand White Rabbit, Xenograft Hydroxyapatite Bovine, And Xenograft Demineralized Bone Matrix Bovine In Bone Defect Of Femoral Diaphysis White Rabbit Experimental Study In Vivo

2017 ◽  
Vol 3 (6) ◽  
pp. 344 ◽  
Author(s):  
Ferdiansyah Ferdiansyah ◽  
Dwikora Novembri Utomo ◽  
Heri Suroto
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Zealand White Rabbit ◽  
Femoral Diaphysis ◽  
Autogenous Bone ◽  
Rejection Reaction ◽  
Freeze Dried ◽  
Demineralized Bone

Bone defect remains a big challenge for orthopedic surgeon. Bone grafting nowadays become the second common transplantation after blood transfusion. Autogenous bone graft is the gold standard in treatment of bone defect, but it’s source limitation and donor site morbidity makes some surgeon were looking for allograft or xenograft. There are some issues with allo- and xenograft about difficulty in corporation and rejection reaction. This study explores the immunogenicity of allograft and xenograft. Keyword :  freeze-dried xenograft, freeze-dried allograft, hydroxyapatite xenograft, demineralized bone matrix xenograft.

Bioactive Glass Granules as Extender of Autogenous Bone Grafting in Cementless Intercalary Implant of the Canine Femur

2007 ◽  
Vol 96 (3) ◽  
pp. 243-251 ◽  
Author(s):  
P. Keränen ◽  
A. Itälä ◽  
J. Koort ◽  
I. Kohonen ◽  
M. Dalstra ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Graft ◽  
Bone Grafting ◽  
Paired Comparison ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Allogeneic Bone ◽  
Implant Surface ◽  
Autogenous Bone Grafting ◽  
Torsional Testing

Background and Aims: Ceramic bone graft substitutes have a potential to be used as replacement of allogeneic bone grafting and, under optimal distribution of particle size, they may even provide mechanical support. The current study examined the efficacy of bioactive glass granules as an extender of autogenous bone grafting in a segmental bone replacement model of the canine femur. Material and Method: A 16 mm long segment of the femur shaft was bilaterally replaced with an intercalary titanium implant in eight animals. The implant had cementless grooved proximal and distal stems. In one leg, the peri-implant space was packed with composite graft consisting of a mixture of bioactive glass granules and autogenous bone graft in proportion of 50:50. In the opposite leg, the peri-implant space was treated with autogenous bone graft alone. After surgery, unlimited functional loading was allowed. The outcome was evaluated at three months. Results: Eight out of sixteen autografted implants and seven out of sixteen composite-grafted implants were radiographically incorporated and clinically stable at three months. In the paired comparison, the proximal components of composite-grafted implants showed lower maximum load under torsional testing (p=0.068), less new bone in the longitudinal grooves of the stems (p=0.036) and lower affinity of new bone to implant surface (p=0.046). The distal components of the two sides showed a similar trend for less new bone in the grooves and lower bone affinity of new bone in the distal composite-grafted components. Conclusions: The current study suggests that supplementation of periprosthetic bone graft with bioactive ceramic particles may not help to promote healing of cementless implants under high dynamic loading conditions.

Treatment of Benign Bone Tumors of the Hand Using Demineralized Bone Matrix

2009 ◽  
Vol 123 (6) ◽  
pp. 214e-216e ◽  
Author(s):  
Jeffrey V. Manchio ◽  
Osak O. Omulepu ◽  
Jeffrey Weinzweig
Keyword(s):  
Bone Tumors ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Benign Bone Tumors ◽  
Tumors Of The Hand ◽  
Demineralized Bone

Bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors

2008 ◽  
Vol 90B (1) ◽  
pp. 131-136 ◽  
Author(s):  
Nina C. Lindfors ◽  
Jouni T. Heikkilä ◽  
Ilona Koski ◽  
Kimmo Mattila ◽  
Allan J. Aho
Keyword(s):  
Bioactive Glass ◽  
Bone Graft ◽  
Bone Tumors ◽  
Autogenous Bone ◽  
Benign Bone Tumors ◽  
Bone Graft Substitutes

Late sarcoma development after curettage and bone grafting of benign bone tumors

2011 ◽  
Vol 77 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Piero Picci ◽  
Gabriela Sieberova ◽  
Marco Alberghini ◽  
Alba Balladelli ◽  
Daniel Vanel ◽  
...  
Keyword(s):  
Bone Grafting ◽  
Bone Tumors ◽  
Benign Bone Tumors

scholarly journals A case of bone defect after removal of a radicular cyst that was implanted with autolyzed, antigen extracted, allogeneic bone matrix.

1997 ◽  
Vol 43 (10) ◽  
pp. 748-750
Author(s):  
Gaku YAMAMOTO ◽  
Keishi TAKIGAMI ◽  
Shin-ichi KAGAMI ◽  
Mitsunobu MORI ◽  
Yoshinori YAMAGUCHI ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Matrix ◽  
Allogeneic Bone ◽  
Radicular Cyst

scholarly journals Packing of Hydroxyapatite Alone Versus Autogenous Bone Graft for the Treatment of Benign Bone Tumors or Bone Cysts.

1998 ◽  
Vol 47 (3) ◽  
pp. 1037-1041
Author(s):  
Osamu Inoue ◽  
Hideyuki Sakamoto ◽  
Naoyuki Matsuda ◽  
Hiroki Maehara ◽  
Kunio Ibaraki
Keyword(s):  
Bone Graft ◽  
Bone Tumors ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Bone Cysts ◽  
Benign Bone Tumors
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