Autoimmune/inflammatory syndrome induced by buttock augmentation with silicone
Abstract A 37-year-old lady presented to Rheumatology with a three-year history of arthralgia, night sweats, and bilateral swollen buttocks. She described unusual levels of fatigue, memory disturbance and low-grade fevers without lymphadenopathy. She had silicone buttock augmentation 10 years earlier. Inflammatory markers, ANA, ENA, ANCA, ACE, immunoglobulins and IgG subclasses were normal; urinalysis was negative. Pelvic MRI demonstrated extensive abnormal signal change in keeping with silicone deposition within the buttocks, and an inflammatory response extending into the gluteus maximus muscles and surrounding subcutaneous fat. Areas of reduced T2 signal suggested a secondary granulomatous reaction.