scholarly journals The relationship between glycated haemoglobin levels and the risk of giant cell arteritis – a case–control study

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Chetan Mukhtyar ◽  
Holly Myers ◽  
Colin Jones ◽  
Ketan Dhatariya
Keyword(s):  
Diabetes Mellitus ◽  
Case Control Study ◽  
Glycated Haemoglobin ◽  
Primary Outcome Measure ◽  
Case Control ◽  
Retrospective Case ◽  
Core Dataset ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study

Abstract Objectives The EULAR core dataset for observational studies in GCA does not include glycated haemoglobin (HbA1c). A multivariable score to stratify the pre-test probability of GCA also does not include HbA1c. There have been contradictory reports about diabetes mellitus being a risk factor for GCA. We report the first study analysing the relationship of pre-diagnosis HbA1c with the risk of GCA. Methods This was a single-centre retrospective case–control study conducted in Norfolk, UK. All GCA cases were diagnosed with imaging or biopsy. Each case was assigned two age- and sex-matched controls. The primary outcome measure was the glycaemic status (HbA1c categorized into euglycaemia, pre-diabetes or diabetes mellitus) at diagnosis between cases and controls. The HbA1c was compared between two groups using the Mann–Whitney U test. The glycaemic categorization was compared using the χ2 test. Results One hundred and twelve cases and 224 controls were included. The median (interquartile range) of HbA1c of cases and controls was 40 (37, 43) and 41 (39, 47) mmol/mol (P < 0.001), respectively. Ten of 112 cases and 52 of 224 controls had diabetes mellitus. The χ2 test demonstrated a significant interaction between glycaemic state and GCA (P = 0.006). Individuals with diabetes mellitus had an odds ratio (95% CI) of 0.32 (0.13, 0.74) (P = 0.008) of having GCA compared with euglycaemic individuals. Conclusion HbA1c in the diabetic range reduces the probability of GCA. HbA1c should be considered in any multivariable score to calculate the risk of GCA, and in future development of diagnostic and classification criteria. There is a need for an epidemiological study looking at the possibility of a protective nature of diabetes mellitus against GCA or whether it is only a mimic.

scholarly journals Association of Higher Circulating Insulin Antibody with Increased Mean Amplitude Glycemic Excursion in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional, Retrospective Case-Control Study

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Jian Zhu ◽  
Lu Yuan ◽  
Wen-ji Ni ◽  
Yong Luo ◽  
Jian-hua Ma
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Case Control Study ◽  
Mean Amplitude ◽  
Case Control ◽  
Retrospective Case ◽  
Cross Sectional ◽  
The Relationship ◽  
Control Study

Insulin antibody (IA) may potentially affect a patient’s glycemic control due to its variability in both binding and/or releasing insulin. However, the association between IA titer and daily glycemic variability (GV) is still unknown. We thus performed this cross-sectional, retrospective case-control study to assess the relationship between IA titer and mean amplitude glycemic excursion (MAGE) in type 2 diabetes mellitus (T2DM) patients using a continuous glucose monitoring (CGM) system. We recruited 100 eligible patients (IA>5%, IA positive) and divided them into two groups—a low (L) group and a high (H) group—based on their IA titer. The control (C) group consisted of 47 patients (IA≤5%, IA negative) matched for age, BMI, gender, and glycosylated hemoglobin A1c (HbA1c). The CGM determined the GV of enrolled patients. The primary outcome was the relationship between the IA titer and the MAGE, and the secondary outcome was the differences of GV among the three groups. We found that patients in the H group had higher levels of blood glucose fluctuation parameters than those in the L and C groups. The Ln(IA) was positively correlated with Ln(MAGE) even after adjusting for age, gender, BMI, HbA1c, and fasting and postprandial C-peptide(r=0.423, p<0.001). Multiple linear stepwise regression analysis revealed that Ln(IA) was an independent factor of Ln(MAGE) (beta=0.405, p<0.001). In conclusion, the higher circulating IA titer was associated with increased MAGE in T2DM patients, indicating that those patients with elevated IA titer should receive GV assessment and individualized treatment.

scholarly journals Relationship of Tuberculosis Radiographic Manifestation in Diabetic Patients with HbA1c Levels

2019 ◽  
Vol 39 (3) ◽  
pp. 154-159
Author(s):  
Dana Jauhara Layali ◽  
Bintang YM Sinaga ◽  
Parluhutan Siagian ◽  
Putri Chairani Eyanoer
Keyword(s):  
Diabetes Mellitus ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Pulmonary Tb ◽  
Relationship Of ◽  
The Relationship ◽  
Significant Health ◽  
Control Study ◽  
Hba1c Levels

Background: The relationship between diabetes mellitus (DM) and tuberculosis (TB) is a significant health problem and more prominent in developing countries where TB is endemic and DM prevalence increases. The prevalence of pulmonary TB increases with increasing prevalence of DM. Uncontrolled diabetic patients with high hemoglobin (HbA1c) levels cause TB to become more severe and are associated with higher mortality and also have a significant effect on radiological manifestations of pulmonary TB. Methods: The was a case-control study conducted between January to December 2016 at RSUP H Adam Malik, Medan to 43 with TB-DM patients and 41 TB-without DM patients was studied from. Radiological examination with chest radiograph was done in both groups of samples. The HbA1c levels was examined in the TB with DM group. Result: Compared with TB-without DM group, the TB with DM group significantly had far advanced tuberculosis lesions (OR=3.8; 95% CI=1.37-10.47; P=0.01), more atypical lesions atipikal (OR=6.29; 95% CI=2.43-16.25; P

scholarly journals The Relationship of Residential Environment with The Risk of Leptospirosis in Sleman Regency

2017 ◽  
Vol 1 (2) ◽  
pp. 85-92
Author(s):  
Maya Sofiyani ◽  
M Imron Mawardi ◽  
P Sigit Purnomo ◽  
Hariza Adnani
Keyword(s):  
Environmental Factors ◽  
Case Control Study ◽  
Case Control ◽  
Survey Method ◽  
Control Programs ◽  
The Government ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study ◽  
Made In

The effort of leptospirosis prevention in Sleman currently only limited to counseling and treatment of the patient, while the patient search, ways of transmission of leptospirosis from rats to humans, have never implemented in an integrated manner. The study aimed to investigated the relationship between the environmental residential condition with the risk of leptospirosis in Sleman Regency. The research used a survey method  with case control study design. The results showed that environmental factors, which are not proved to have a relationship with the risk of leptospirosis were residential condition ({p=0,108} OR=3,818 {95%CI:0,922–15,811}), the trash bin condition ({p=1,000} OR=1,138 {95%CI:0,420–3,081}) and the sewer condition ({p=0,415} OR=0,551 {95%CI:0,187–1,624}). Environmental factors that associated with the risk of leptospirosis was the presence of rats ({p=0,001} OR=13,594 {95%CI:2,754–67,107}). The effort should be made in order to prevent the increasement of Leptospirosis cases by sanitation improvement and avoiding direct contact with rats as well as it litter. The Government should be pay more attention in the vector control programs, especially in leptospirosis prone areas so the prevention effort to be able run effectively and efficiently.

The Relationship of Drug Therapy to Aplastic Anemia in Pakistan: A Hospital-Based Case Control Study

2021 ◽  
Vol Volume 17 ◽  
pp. 903-908
Author(s):  
Muhammad Asif Syed ◽  
Aneela Atta Ur Rahman ◽  
Muhammad Nadeem Shah Syed ◽  
Naveed Masood Memon
Keyword(s):  
Drug Therapy ◽  
Aplastic Anemia ◽  
Case Control Study ◽  
Case Control ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study
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