scholarly journals Physical Activity and Exercise Outcomes in Huntington Disease (PACE-HD): Protocol for a 12-Month Trial Within Cohort Evaluation of a Physical Activity Intervention in People With Huntington Disease

2019 ◽  
Vol 99 (9) ◽  
pp. 1201-1210 ◽  
Author(s):  
Cheney J G Drew ◽  
Lori Quinn ◽  
Katy Hamana ◽  
Rhys Williams-Thomas ◽  
Lucy Marsh ◽  
...  
Keyword(s):  
Physical Activity ◽  
Observational Study ◽  
Huntington Disease ◽  
Physical Activity Intervention ◽  
The United States ◽  
Exercise Participation ◽  
Cohort Design ◽  
Longitudinal Observational Study ◽  
Physical Activity And Exercise

AbstractBackgroundExercise is emerging as an important aspect in the management of disease-related symptoms and functional decline in people with Huntington disease (HD). Long-term evaluation of physical activity and exercise participation in HD has yet to be undertaken.ObjectiveThe objective is to investigate the feasibility of a nested randomized controlled trial (RCT) alongside a longitudinal observational study of physical activity and exercise outcomes in people with HD.DesignThis will be a 12-month longitudinal observational study (n = 120) with a nested evaluation of a physical activity intervention (n = 30) compared with usual activity (n = 30) using a “trial within a cohort” design.SettingThe study will take place in HD specialist clinics in Germany, Spain, and the United States, with intervention delivery in community settings.ParticipantsThe participants will have early-mid–stage HD and be participating in the Enroll-HD study.InterventionThis will be a 12-month physical activity behavioral change intervention, delivered by physical therapists in 18 sessions, targeting uptake of aerobic exercise and increased physical activity.MeasurementsAll participants (n = 120) will complete Enroll-HD assessments (motor, cognitive, behavioral, and quality of life) at baseline and at 12 months. Additional Physical ACtivity and Exercise Outcomes in Huntington Disease (PACE-HD) assessments include fitness (predicted maximal oxygen uptake [V  o2max]), self-reported and quantitative measures of physical activity, disease-specific symptoms, and walking endurance. RCT participants (n = 60) will complete an additional battery of quantitative motor assessments and a 6-month interim assessment. Enroll-HD data will be linked to PACE-HD physical activity and fitness data.LimitationsThe limitations include that the embedded RCT is open, and assessors at RCT sites are not blinded to participant allocation.ConclusionPACE-HD will enable determination of the feasibility of long-term physical activity interventions in people with HD. The novel “trial within a cohort” design and incorporation of data linkage have potential to reduce participant burden. This design could be applied to other neurological diseases and movement disorders where recruitment and retention are challenging.

scholarly journals Effects of a 1-Year Physical Activity Intervention on Markers of Hemostasis among Breast Cancer Survivors: A Randomized Controlled Trial

TH Open ◽  
2021 ◽  
Vol 05 (01) ◽  
pp. e14-e23
Author(s):  
Siv Kjølsrud Bøhn ◽  
Inger Thune ◽  
Vidar Gordon Flote ◽  
Hanne Frydenberg ◽  
Gro Falkenér Bertheussen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Postmenopausal Women ◽  
Cancer Patients ◽  
Physical Activity Intervention ◽  
Intervention Group ◽  
Factor Vii ◽  
Breast Cancer Patients ◽  
Hemostatic Factors

Abstract Introduction Physical activity may reduce the development of breast cancer. Whereas hypercoagulability has been linked to adverse outcomes in breast cancer patients, the effects of physical activity on their hemostatic factors are unknown. The study aimed to assess whether long-term (1 year) physical activity can affect hemostatic factors in breast cancer patients. Methods Fifty-five women (35–75 years) with invasive breast cancer stage I/II were randomized to a physical activity intervention (n = 29) lasting 1 year or to a control group (n = 26), and analyzed as intention to treat. Fibrinogen, factor VII antigen, tissue factor pathway inhibitor, and von Willebrand factor (VWF) antigen as well as prothrombin fragment 1 + 2, the endogenous thrombin potential and D-dimer, were measured in plasma before intervention (baseline), and then after 6 and 12 months. Results Maximal oxygen uptake (measure of cardiorespiratory fitness) decreased the first 6 months among the controls, but remained stable in the intervention group. We found no significant differences between the two study groups regarding any of the hemostatic factors, except a significantly higher increase in factor VII antigen in the intervention group. The effect of the intervention on VWF was, however, significantly affected by menopausal stage, and a significant effect of the intervention was found on VWF among postmenopausal women, even after adjustment for dietary intake. Conclusion Long-term physical activity had no effect on the majority of the hemostatic factors measured, but led to increased plasma concentrations of factor VII antigen and prevented an increase in VWF concentration after breast cancer treatment in postmenopausal women. The clinical impact of these findings for risk of vascular thrombosis warrants further studies.

Association of Behavioral Phenotypes With Changes in Sleep During a Workplace Wellness Program

2021 ◽  
pp. 089011712110150
Author(s):  
Kimberly J. Waddell ◽  
Sujatha Changolkar ◽  
Gregory Szwartz ◽  
Sarah Godby ◽  
Mitesh S. Patel
Keyword(s):  
Physical Activity ◽  
Sleep Duration ◽  
Physical Activity Intervention ◽  
Secondary Analysis ◽  
The United States ◽  
Behavioral Phenotype ◽  
Workplace Wellness ◽  
Wellness Program ◽  
Behavioral Phenotypes ◽  
Physically Active

Purpose: Examine changes in sleep duration by 3 behavioral phenotypes during a workplace wellness program with overweight and obese adults. Design: Secondary analysis of a randomized clinical trial Setting: Remotely monitored intervention conducted across the United States Subjects: 553 participants with a body mass index ≥25 Intervention: Participants were randomized to 1 of 4 study arms: control, gamification with support, gamification with collaboration, and gamification with competition to increase their physical activity. All participants were issued a wrist-worn wearable device to record their daily physical activity and sleep duration. Measures: The primary outcome was change in daily sleep duration from baseline during the 24 week intervention and follow-up period by study arm within behavioral phenotype class. Analysis: Linear mixed effects regression. Results: Participants who had a phenotype of less physically active and less social at baseline, in the gamification with collaboration arm, significantly increased their sleep duration during the intervention period (30.2 minutes [95% CI 6.9, 53.5], P = 0.01), compared to the control arm. There were no changes in sleep duration among participants who were more extroverted and motivated or participants who were less motivated and at-risk. Conclusions: Changes in sleep during a physical activity intervention varied by behavioral phenotype. Behavioral phenotypes may help to precisely identify who is likely to improve sleep duration during a physical activity intervention.

Utilization of Collaborations to Engage Children in Physical Activity: A Community-Based Research Approach

2017 ◽  
Vol 6 (4) ◽  
pp. 323-328
Author(s):  
Sheri J. Brock ◽  
Danielle Wadsworth ◽  
Shelby Foote ◽  
Mary E. Rudisill
Keyword(s):  
Physical Activity ◽  
The United States ◽  
Research Approach ◽  
Collaborative Partnerships ◽  
Community Based ◽  
Community Partners ◽  
Community Based Research ◽  
Quality Product ◽  
Long Term Impact

Institutions of higher education have a responsibility to prioritize the needs of society and local communities. One essential need prevalent in all communities is to address the rise of obesity and health risks due to lack of participation in physical activity. In the United States, children spend a small percentage of time engaged in physical activity, and engagement decreases further in adolescence and adulthood. Collaborative partnerships between kinesiology faculty at universities and community organizations are one avenue for engaging children in physical activity. Partnerships must be multilevel and community wide to evoke change and have long-term impact and sustainability. Within the context of community-based research, we propose a three-step framework for establishing collaborative partnerships: (1) determining the needs of partners; (2) discussing expertise, services, and philosophy; and (3) providing a quality product. In addition, we outline and illustrate our experiences when collaborating with community partners to promote physical activity.

Determining the Long-Term Effectiveness of a Group-Based Physical Activity Program

2018 ◽  
Vol 20 (3) ◽  
pp. 401-408
Author(s):  
Anamica Batra ◽  
Richard C. Palmer ◽  
Elena Bastida ◽  
H. Virginia McCoy ◽  
Hafiz M. R. Khan
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Healthy Aging ◽  
Population Level ◽  
The United States ◽  
South Florida ◽  
Community Based ◽  
Evidence Based Programs ◽  
The Impact

Objective. In 2015, only half (48%) of older adults in the United States (≥60 years) reported engaging in any kind of physical activity. Few studies examine the impact of evidence-based programs when adopted in community-based settings. The purpose of this study is to assess the effectiveness of EnhanceFitness (EF) upto 12-months. Method. EF was offered to older adults in South Florida. A total of 222 EF classes were offered between October 2008 and December 2014. Program consisted of a 1-hour session held three times a week. Even though participation was required for 4 months, 1,295 participants continued the program for at least 1 year. Results. All participants showed significant improvement in outcome measures. A mean change of 1.5, 1.7, and 1.9 was seen in number of chair stands at 4, 8, and 12 months (p < .001), respectively. The number of arm curls performed improved from 16.8 at baseline to 18.8, 18.8, and 19.2 at 4-, 8-, and 12-months, respectively. Participants improved their up-and-go time by decreasing from 9.1 (baseline) to 8.7 (4 months) to 8.6 (12 months; p = .001). Discussion. Randomized controlled trials are commonly used to determine the efficacy of an intervention. These interventions when disseminated at the population level have the potential to benefit large masses. EF is currently offered at more than 700 locations. This tremendous success of EF brings attention to an important question of continuous monitoring of these programs to ensure program consistency and intended outcomes. The model used by the Healthy Aging Regional Collaborative could be replicated by other communities.

scholarly journals Weight loss in conservative treatment of obesity in women is associated with physical activity and circadian phenotype: a longitudinal observational study

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Eva Fárková ◽  
Jakub Schneider ◽  
Michal Šmotek ◽  
Eduard Bakštein ◽  
Jitka Herlesová ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Conservative Treatment ◽  
Observational Study ◽  
Direct Relationship ◽  
Close Connection ◽  
Longitudinal Observational Study ◽  
Treatment Of Obesity ◽  
Rhythm Stability ◽  
Main Factor

Abstract Introduction The study investigates the association between circadian phenotype (CP), its stability (interdaily stability - IS) and physical activity (PA) in a weight loss (WL) programme. Methods Seventy-five women in WL conservative treatment (BMI ≥ 25 kg/m2) were measured (for about 3 months in between 2016 and 2018) by actigraphy. Results We observed a difference in time of acrophase (p = 0.049), but no difference in IS (p = 0.533) between women who lost and did not lose weight. There was a difference in PA (mesor) between groups of women who lost weight compared to those who gained weight (p = 0.007). There was a relationship between IS and PA parametres mesor: p0.001; and the most active 10 h of a day (M10): p < 0.001 - the more stable were women in their rhythm, the more PA they have. Besides confirming a relationship between PA and WL, we also found a relation between WL and CP based on acrophase. Although no direct relationship was found for the indicators of rhythm stability (IS), they can be considered very important variables because of their close connection to PA – a main factor that contributes to the success of the WL programme. Discussion According to the results of the study, screening of the CP and its stability may be beneficial in the creation of an individualized WL plan.

Providing Access to Physical Activity: The Intersection of Teaching, Outreach, and Scholarship

2015 ◽  
Vol 4 (4) ◽  
pp. 409-415
Author(s):  
Danielle D. Wadsworth ◽  
Mary E. Rudisill ◽  
Jared A. Russell ◽  
James R. McDonald ◽  
David D. Pascoe
Keyword(s):  
Physical Activity ◽  
Graduate Students ◽  
Service Learning ◽  
Social Ties ◽  
The United States ◽  
Learning Opportunities ◽  
Training Center ◽  
Research Projects ◽  
Team Handball

The School of Kinesiology at Auburn University unites teaching, research, and outreach efforts to provide access to physical activity for local, statewide, and global communities. This paper provides a brief overview of the programs as well as strategies to mobilize efforts for physical activity outreach within an academic setting. School-wide efforts include youth initiatives, physical activity assessments offered through our TigerFit program, and the United States Olympic Team Handball training center. All programs provide service-learning opportunities for undergraduate and graduate students as well as outreach outcomes. Furthermore, the programs provide a platform for scholarship in the form of publications, partnerships for grant submissions, and student research projects. Merging teaching, outreach, and scholarship has provided longevity for the programs, thereby establishing long-term social ties to the community and providing continued access to physical activity to promote public health.

scholarly journals Long-term efficacy of a printed or a Web-based tailored physical activity intervention among older adults

2013 ◽  
Vol 10 (1) ◽  
pp. 104 ◽  
Author(s):  
Denise Peels ◽  
Catherine Bolman ◽  
Rianne Henrica Johanna Golsteijn ◽  
Hein de Vries ◽  
Aart Mudde ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Physical Activity Intervention ◽  
Web Based ◽  
Term Efficacy
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