scholarly journals The Effect of Epidural Steroid Injections on Bone Mineral Density and Vertebral Fracture Risk: A Systematic Review and Critical Appraisal of Current Literature

Pain Medicine ◽  
2018 ◽  
Vol 19 (3) ◽  
pp. 569-579 ◽  
Author(s):  
Panagiotis Kerezoudis ◽  
Lorenzo Rinaldo ◽  
Mohammed Ali Alvi ◽  
Christine L Hunt ◽  
Wenchun Qu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Systematic Review ◽  
Vertebral Fracture ◽  
Fracture Risk ◽  
Critical Appraisal ◽  
Mineral Density ◽  
Steroid Injections ◽  
Epidural Steroid Injections ◽  
Vertebral Fracture Risk ◽  
Epidural Steroid

352 The Effect of Epidural Steroid Injections on Bone Mineral Density and Vertebral Fracture Risk: A Systematic Review and Critical Appraisal of Current Literature

Neurosurgery ◽  
2017 ◽  
Vol 64 (CN_suppl_1) ◽  
pp. 280-280
Author(s):  
Panagiotis Kerezoudis ◽  
Lorenzo Rinaldo ◽  
Mohammed Ali Alvi ◽  
Sandy Goncalves ◽  
Christine Hunt ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Femoral Neck ◽  
Osteoporotic Fractures ◽  
Mineral Density ◽  
Steroid Injections ◽  
Epidural Steroid Injections ◽  
Vertebral Fracture Risk ◽  
Patients At Risk ◽  
One Year ◽  
Epidural Steroid

Abstract INTRODUCTION Epidural steroid injections (ESIs) are a common treatment for the management of patients with radicular back pain. It is also known that the long-term enteral administration of exogenous steroids disrupts bone health and skeletal micro-architecture METHODS A systematic and critical review of recent literature was conducted in accordance with PRISMA guidelines. RESULTS >A total of 8 studies were included in the analysis (6 retrospective, 2 prospective). A total of 7233 patients with a mean age ranging between 49 and 74 years and an average follow-up between 6 and 60 months were studied. Steroids that were used included triamcinolone, dexamethasone, and methylprednisolone (MP), with a mean number of injections ranging from 1 to 14.7 and average cumulative dose in MP equivalents between 80 and 8130 mg. A single ESI was shown to decrease BMD as measured at the femoral neck by 1.8%, and increase the risk of vertebral fracture by 21%. Significant reductions in BMD were associated with a cumulative MP dose of 200 mg over a one year period and 400 mg over three years, but not in doses of less than 200 mg of MP equivalents for postmenopausal women and at least 3 g for healthy men. The risk of osteopenia and osteoporosis was lower in patients that were receiving anti-osteoporotic medication during the treatment course. CONCLUSION ESIs can decrease BMD, both locally (lumbar spine) and systemically (femoral neck) and increase the risk of vertebral fracture. Therefore, ESIs should be recommended with caution, especially in patients at risk for osteoporotic fractures, such as women of postmenopausal age. Anti-osteoporotic medication might be considered prior to ESI.

Association of PLXNA2 polymorphisms with vertebral fracture risk and bone mineral density in postmenopausal Korean population

2006 ◽  
Vol 17 (11) ◽  
pp. 1592-1601 ◽  
Author(s):  
J. -Y. Hwang ◽  
J. -Y. Lee ◽  
M. -H. Park ◽  
K. -S. Kim ◽  
K. -K. Kim ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Korean Population ◽  
Mineral Density ◽  
Vertebral Fracture Risk

scholarly journals Association of CDX1 binding site of periostin gene with bone mineral density and vertebral fracture risk

2012 ◽  
Vol 23 (7) ◽  
pp. 1877-1887 ◽  
Author(s):  
S.-M. Xiao ◽  
Y. Gao ◽  
C.-L. Cheung ◽  
C. H. Bow ◽  
K.-S. Lau ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Fracture Risk ◽  
Binding Site ◽  
Bone Mineral ◽  
Mineral Density ◽  
Vertebral Fracture Risk

scholarly journals Relationships Between Bone Mineral Density and Incident Vertebral Fracture Risk with Raloxifene Therapy

2002 ◽  
Vol 17 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Somnath Sarkar ◽  
Bruce H. Mitlak ◽  
Mayme Wong ◽  
John L. Stock ◽  
Dennis M. Black ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Mineral Density ◽  
Incident Vertebral Fracture ◽  
Vertebral Fracture Risk

Relationships Between Bone Mineral Density and Incident Vertebral Fracture Risk With Raloxifene Therapy

2002 ◽  
Vol 57 (7) ◽  
pp. 446-448
Author(s):  
Somnath Sarkar ◽  
Bruce H. Mitlak ◽  
Mayme Wong ◽  
John L. Stock ◽  
Dennis M. Black ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Mineral Density ◽  
Incident Vertebral Fracture ◽  
Vertebral Fracture Risk

Vertebral Fracture Risk Is Reduced for Women Who Lose Femoral Neck Bone Mineral Density During Teriparatide Treatment

2008 ◽  
Vol 11 (3) ◽  
pp. 465 ◽  
Author(s):  
Nelson B. Watts ◽  
Paul D. Miller ◽  
Robert Marcus ◽  
Peiqi Chen ◽  
Jody Arsenault ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Femoral Neck ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Mineral Density ◽  
Teriparatide Treatment ◽  
Vertebral Fracture Risk

scholarly journals Effect of Lumbar Epidural Steroid Injections on Osteoporotic Fracture and Bone Mineral Density in Elderly Women with Diabetes Mellitus

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Minsoo Kim ◽  
Jiwon Bak ◽  
Sejin Kim ◽  
Hee-Jeong Son ◽  
Seong-Sik Kang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Elderly Women ◽  
Osteoporotic Fractures ◽  
Mineral Density ◽  
Steroid Injections ◽  
Epidural Steroid Injections ◽  
The Mean ◽  
Epidural Steroid

The incidence of osteoporosis and diabetes mellitus (DM) is known to increase with aging. DM is associated with osteoporotic fractures and decreased bone mineral metabolism. However, no studies have compared the effects of DM on the changes in bone mineral density (BMD) and osteoporotic fracture after epidural steroid injections (ESIs). The present study aimed to analyze the relationship between ESI and BMD changes in elderly women with and without DM. The medical records of elderly women who underwent ESI were retrospectively analyzed. All patients had radiographic and BMD assessments performed before and after receiving lumbar ESIs. A total of 172 patients were divided into two groups according to the presence of DM. The duration of BMD monitoring was 16.1 and 16.8 months in the non-DM and DM groups, respectively. The mean total number of ESIs was 3.4 and 3.2, and the mean cumulative administered dose of glucocorticoids (dexamethasone) was 17 and 16 mg in the non-DM and DM groups, respectively. There were no significant differences between baseline and posttreatment BMD in the lumbar spine, total femur, and femoral neck region in either group. The incidence of osteoporotic fractures at the hip joint and thoracolumbar spine was not significantly different in both groups. ESIs could be used without concerns regarding osteoporosis and fractures in elderly women with DM if low doses of glucocorticoids are used.

scholarly journals Association of Cdx1 binding site of periostin gene with bone mineral density and vertebral fracture risk

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S158-S159
Author(s):  
S.-M. Xiao ◽  
Y. Gao ◽  
C.-L. Cheung ◽  
C.H. Bow ◽  
K.-S. Lau ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vertebral Fracture ◽  
Fracture Risk ◽  
Binding Site ◽  
Bone Mineral ◽  
Mineral Density ◽  
Vertebral Fracture Risk
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