scholarly journals Erratum to: Two ubiquitin-associated ER proteins interact with COPT copper transporters and modulate their accumulation

2021 ◽  
Author(s):  
Xifeng Li ◽  
Zhe Wang ◽  
Yunting Fu ◽  
Xi Cheng ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Copper Transporters

The role of copper transporters in the development of resistance to Pt drugs

2004 ◽  
Vol 98 (10) ◽  
pp. 1607-1613 ◽  
Author(s):  
Roohangiz Safaei ◽  
Alison K. Holzer ◽  
Kuniyuki Katano ◽  
Goli Samimi ◽  
Stephen B. Howell
Keyword(s):  
Copper Transporters ◽  
Development Of Resistance

Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification

2013 ◽  
Vol 454 (1) ◽  
pp. 147-156 ◽  
Author(s):  
Nataliya V. Dolgova ◽  
Sergiy Nokhrin ◽  
Corey H. Yu ◽  
Graham N. George ◽  
Oleg Y. Dmitriev
Keyword(s):  
Metal Binding ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Binding Domain ◽  
Binding Motif ◽  
Copper Chaperone ◽  
Copper Binding ◽  
Copper Transporters ◽  
Metal Binding Domain ◽  
Disease Protein

Human copper transporters ATP7B (Wilson's disease protein) and ATP7A (Menkes' disease protein) have been implicated in tumour resistance to cisplatin, a widely used anticancer drug. Cisplatin binds to the copper-binding sites in the N-terminal domain of ATP7B, and this binding may be an essential step of cisplatin detoxification involving copper ATPases. In the present study, we demonstrate that cisplatin and a related platinum drug carboplatin produce the same adduct following reaction with MBD2 [metal-binding domain (repeat) 2], where platinum is bound to the side chains of the cysteine residues in the CxxC copper-binding motif. This suggests the same mechanism for detoxification of both drugs by ATP7B. Platinum can also be transferred to MBD2 from copper chaperone Atox1, which was shown previously to bind cisplatin. Binding of the free cisplatin and reaction with the cisplatin-loaded Atox1 produce the same protein-bound platinum intermediate. Transfer of platinum along the copper-transport pathways in the cell may serve as a mechanism of drug delivery to its target in the cell nucleus, and explain tumour-cell resistance to cisplatin associated with the overexpression of copper transporters ATP7B and ATP7A.

scholarly journals ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase

2018 ◽  
Vol 293 (52) ◽  
pp. 20085-20098 ◽  
Author(s):  
Katharina Schmidt ◽  
Martina Ralle ◽  
Thomas Schaffer ◽  
Samuel Jayakanthan ◽  
Bilal Bari ◽  
...  
Keyword(s):  
Copper Transporters

scholarly journals Characterization of the Copper Transporters from Lotus spp. and Their Involvement under Flooding Conditions

2019 ◽  
Vol 20 (13) ◽  
pp. 3136 ◽  
Author(s):  
Francisco J. Escaray ◽  
Cristian J. Antonelli ◽  
Guillermo J. Copello ◽  
Sergi Puig ◽  
Lola Peñarrubia ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Higher Plants ◽  
Economic Losses ◽  
Copper Uptake ◽  
Copper Transporter ◽  
Copper Transporters ◽  
Transporter Family ◽  
Adaptive Mechanisms ◽  
High Prevalence ◽  
Natural Grassland

Forage legumes are an important livestock nutritional resource, which includes essential metals, such as copper. Particularly, the high prevalence of hypocuprosis causes important economic losses to Argentinian cattle agrosystems. Copper deficiency in cattle is partially due to its low content in forage produced by natural grassland, and is exacerbated by flooding conditions. Previous results indicated that incorporation of Lotus spp. into natural grassland increases forage nutritional quality, including higher copper levels. However, the biological processes and molecular mechanisms involved in copper uptake by Lotus spp. remain poorly understood. Here, we identify four genes that encode putative members of the Lotus copper transporter family, denoted COPT in higher plants. A heterologous functional complementation assay of the Saccharomyces cerevisiae ctr1∆ctr3∆ strain, which lacks the corresponding yeast copper transporters, with the putative Lotus COPT proteins shows a partial rescue of the yeast phenotypes in restrictive media. Under partial submergence conditions, the copper content of L. japonicus plants decreases and the expression of two Lotus COPT genes is induced. These results strongly suggest that the Lotus COPT proteins identified in this work function in copper uptake. In addition, the fact that environmental conditions affect the expression of certain COPT genes supports their involvement in adaptive mechanisms and envisages putative biotechnological strategies to improve cattle copper nutrition.

scholarly journals Two Chlamydomonas CTR Copper Transporters with a Novel Cys-Met Motif Are Localized to the Plasma Membrane and Function in Copper Assimilation

2009 ◽  
Vol 21 (3) ◽  
pp. 928-943 ◽  
Author(s):  
M. Dudley Page ◽  
Janette Kropat ◽  
Patrice P. Hamel ◽  
Sabeeha S. Merchant
Keyword(s):  
Plasma Membrane ◽  
Copper Transporters ◽  
And Function

scholarly journals Localization of copper and copper transporters in the human brain

Metallomics ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Katherine M. Davies ◽  
Dominic J. Hare ◽  
Veronica Cottam ◽  
Nicholas Chen ◽  
Leon Hilgers ◽  
...  
Keyword(s):  
Human Brain ◽  
Copper Transporters

scholarly journals Host Cell Copper Transporters CTR1 and ATP7A are important for Influenza A virus replication

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Jonathan C. Rupp ◽  
Manon Locatelli ◽  
Alexis Grieser ◽  
Andrea Ramos ◽  
Patricia J. Campbell ◽  
...  
Keyword(s):  
Host Cell ◽  
Influenza A Virus ◽  
Virus Replication ◽  
Influenza A ◽  
Copper Transporters

scholarly journals SLC31 (CTR) family of copper transporters in health and disease

2013 ◽  
Vol 34 (2-3) ◽  
pp. 561-570 ◽  
Author(s):  
Heejeong Kim ◽  
Xiaobin Wu ◽  
Jaekwon Lee
Keyword(s):  
Copper Transporters ◽  
Health And Disease
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