scholarly journals Peroxisomes as Redox-Signaling Nodes in Intracellular Communication and Stress Responses

2021 ◽  
Author(s):  
Luisa M Sandalio ◽  
Maria Angeles Peláez-Vico ◽  
Eliana Molina-Moya ◽  
Maria C Romero-Puertas
Keyword(s):  
Stress Responses ◽  
Redox Signaling ◽  
Intracellular Communication

scholarly journals Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity, and Aging

2018 ◽  
Author(s):  
Collin Y. Ewald
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
Enzymatic Activity ◽  
Stress Responses ◽  
Healthy Aging ◽  
Model Organism ◽  
Redox Signaling ◽  
Small Gtpases ◽  
Endoplasmic Reticulum Membrane ◽  
Nadph Oxidases

An accumulating body of evidence suggests that physiological reactive oxygen species (ROS) generated by NADPH oxidases act as a redox signal to re-establish homeostasis, a capacity that progressively declines during aging, but is maintained in long-lived animals to promote healthy aging. In the model organism Caenorhabditis elegans, ROS generated by dual oxidases (Duox) are important for extracellular matrix integrity, pathogen defense, oxidative stress resistance, and longevity. The Duox enzymatic activity is tightly regulated and under cellular control. Developmental molting cycles, pathogen infections, toxins, mitochondrial-derived ROS, drugs, and small GTPases (RHO-1) can activate Duox (BLI-3) to generate ROS, whereas NADPH oxidase inhibitors and negative regulators, such as MEMO-1, can inhibit Duox to generate ROS. Three mechanisms-of-action have been discovered for the Duox/BLI-3-generated ROS: 1) enzymatic activity to catalyze cross-linking of free tyrosine ethyl ester in collagen bundles to stabilize extracellular matrices, 2) high ROS bursts/levels to kill pathogens, and 3) Redox signaling activating downstream kinase cascades to transcription factors orchestrating oxidative stress- and immunity responses to re-establish homeostasis. Although Duox function at the cell surface is well established, recent genetic and biochemical data also suggests a novel role for Duoxs at the endoplasmic reticulum membrane to control redox signaling. Evidence underlying these mechanisms initiated by ROS from NADPH oxidases and their relevance for human aging are discussed in this review. Appropriately controlling NADPH oxidase activity for local and physiological redox signaling to maintain cellular homeostasis might be a therapeutic strategy to promote healthy aging.

Glutathione, Stress Responses, and Redox Signaling in Lung Inflammation

2005 ◽  
Vol 7 (1-2) ◽  
pp. 42-59 ◽  
Author(s):  
Irfan Rahman ◽  
Saibal K. Biswas ◽  
Luis A. Jimenez ◽  
Martine Torres ◽  
H.J. Forman
Keyword(s):  
Stress Responses ◽  
Lung Inflammation ◽  
Redox Signaling

scholarly journals S-Nitrosoglutathione Reductase-Modulated Redox Signaling Controls Sodic Alkaline Stress Responses in Solanum lycopersicum L.

2014 ◽  
Vol 56 (4) ◽  
pp. 790-802 ◽  
Author(s):  
Biao Gong ◽  
Dan Wen ◽  
Xiufeng Wang ◽  
Min Wei ◽  
Fengjuan Yang ◽  
...  
Keyword(s):  
Solanum Lycopersicum ◽  
Stress Responses ◽  
Redox Signaling ◽  
Alkaline Stress ◽  
Solanum Lycopersicum L

scholarly journals Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging

Antioxidants ◽  
2018 ◽  
Vol 7 (10) ◽  
pp. 130 ◽  
Author(s):  
Collin Ewald
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
Enzymatic Activity ◽  
Stress Responses ◽  
Healthy Aging ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Redox Signaling ◽  
Small Gtpases ◽  
Endoplasmic Reticulum Membrane ◽  
Nadph Oxidases

An accumulating body of evidence suggests that transient or physiological reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases act as a redox signal to re-establish homeostasis. The capacity to re-establish homeostasis progressively declines during aging but is maintained in long-lived animals to promote healthy aging. In the model organism Caenorhabditis elegans, ROS generated by dual oxidases (Duox) are important for extracellular matrix integrity, pathogen defense, oxidative stress resistance, and longevity. The Duox enzymatic activity is tightly regulated and under cellular control. Developmental molting cycles, pathogen infections, toxins, mitochondrial-derived ROS, drugs, and small GTPases (e.g., RHO-1) can activate Duox (BLI-3) to generate ROS, whereas NADPH oxidase inhibitors and negative regulators, such as MEMO-1, can inhibit Duox from generating ROS. Three mechanisms-of-action have been discovered for the Duox/BLI-3-generated ROS: (1) enzymatic activity to catalyze crosslinking of free tyrosine ethyl ester in collagen bundles to stabilize extracellular matrices, (2) high ROS bursts/levels to kill pathogens, and (3) redox signaling activating downstream kinase cascades to transcription factors orchestrating oxidative stress and immunity responses to re-establish homeostasis. Although Duox function at the cell surface is well established, recent genetic and biochemical data also suggests a novel role for Duoxs at the endoplasmic reticulum membrane to control redox signaling. Evidence underlying these mechanisms initiated by ROS from NADPH oxidases, and their relevance for human aging, are discussed in this review. Appropriately controlling NADPH oxidase activity for local and physiological redox signaling to maintain cellular homeostasis might be a therapeutic strategy to promote healthy aging.

scholarly journals Redox signaling through zinc activates the radiation response in Deinococcus bacteria

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Romaric Magerand ◽  
Pascal Rey ◽  
Laurence Blanchard ◽  
Arjan de Groot
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Stress Responses ◽  
Redox Homeostasis ◽  
Redox Signaling ◽  
Molecular Signaling ◽  
Signaling Mechanism ◽  
Zinc Excess ◽  
Metalloprotease Activity ◽  
And Oxidative Stress

AbstractDeinococcus bacteria are extremely resistant to radiation and other DNA damage- and oxidative stress-generating conditions. An efficient SOS-independent response mechanism inducing expression of several DNA repair genes is essential for this resistance, and is controlled by metalloprotease IrrE that cleaves and inactivates transcriptional repressor DdrO. Here, we identify the molecular signaling mechanism that triggers DdrO cleavage. We show that reactive oxygen species (ROS) stimulate the zinc-dependent metalloprotease activity of IrrE in Deinococcus. Sudden exposure of Deinococcus to zinc excess also rapidly induces DdrO cleavage, but is not accompanied by ROS production and DNA damage. Further, oxidative treatment leads to an increase of intracellular free zinc, indicating that IrrE activity is very likely stimulated directly by elevated levels of available zinc ions. We conclude that radiation and oxidative stress induce changes in redox homeostasis that result in IrrE activation by zinc in Deinococcus. We propose that a part of the zinc pool coordinated with cysteine thiolates is released due to their oxidation. Predicted regulation systems involving IrrE- and DdrO-like proteins are present in many bacteria, including pathogens, suggesting that such a redox signaling pathway including zinc as a second messenger is widespread and participates in various stress responses.

Apoplastic and Chloroplastic Redox Signaling Networks in Plant Stress Responses

2013 ◽  
Vol 18 (16) ◽  
pp. 2220-2239 ◽  
Author(s):  
Maija Sierla ◽  
Moona Rahikainen ◽  
Jarkko Salojärvi ◽  
Jaakko Kangasjärvi ◽  
Saijaliisa Kangasjärvi
Keyword(s):  
Stress Responses ◽  
Plant Stress ◽  
Redox Signaling ◽  
Signaling Networks ◽  
Plant Stress Responses

Acquiring control: The evolution of ROS-Induced oxidative stress and redox signaling pathways in plant stress responses

2019 ◽  
Vol 141 ◽  
pp. 353-369 ◽  
Author(s):  
Muhammad Ansar Farooq ◽  
Adnan Khan Niazi ◽  
Javaid Akhtar ◽  
Saifullah ◽  
Muhammad Farooq ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathways ◽  
Stress Responses ◽  
Plant Stress ◽  
Redox Signaling ◽  
Plant Stress Responses

Emotions and health: The impact of emotions, emotions regulation, music, and acculturation on health

2008 ◽  
Vol 16 (3) ◽  
pp. 112-115 ◽  
Author(s):  
Stephan Bongard ◽  
Volker Hodapp ◽  
Sonja Rohrmann
Keyword(s):  
Stress Responses ◽  
Physiological Stress ◽  
Anger Expression ◽  
Domain Specific ◽  
Cardiovascular Stress ◽  
Expression Behavior ◽  
Cardio Vascular ◽  
And Coping ◽  
Relationship Of ◽  
The Impact

Abstract. Our unit investigates the relationship of emotional processes (experience, expression, and coping), their physiological correlates and possible health outcomes. We study domain specific anger expression behavior and associated cardio-vascular loads and found e.g. that particularly an open anger expression at work is associated with greater blood pressure. Furthermore, we demonstrated that women may be predisposed for the development of certain mental disorders because of their higher disgust sensitivity. We also pointed out that the suppression of negative emotions leads to increased physiological stress responses which results in a higher risk for cardiovascular diseases. We could show that relaxation as well as music activity like singing in a choir causes increases in the local immune parameter immunoglobuline A. Finally, we are investigating connections between migrants’ strategy of acculturation and health and found e.g. elevated cardiovascular stress responses in migrants when they where highly adapted to the German culture.

Childbirth and Posttraumatic Stress Responses

2006 ◽  
Vol 22 (4) ◽  
pp. 259-267 ◽  
Author(s):  
Eelco Olde ◽  
Rolf J. Kleber ◽  
Onno van der Hart ◽  
Victor J.M. Pop
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Responses ◽  
Rating Scales ◽  
Rating Scale ◽  
Stress Disorder ◽  
Traumatic Experience ◽  
Event Scale ◽  
Self Rating ◽  
The Impact

Childbirth has been identified as a possible traumatic experience, leading to traumatic stress responses and even to the development of posttraumatic stress disorder (PTSD). The current study investigated the psychometric properties of the Dutch version of the Impact of Event Scale-Revised (IES-R) in a group of women who recently gave birth (N = 435). In addition, a comparison was made between the original IES and the IES-R. The scale showed high internal consistency (α = 0.88). Using confirmatory factor analysis no support was found for a three-factor structure of an intrusion, an avoidance, and a hyperarousal factor. Goodness of fit was only reasonable, even after fitting one intrusion item on the hyperarousal scale. The IES-R correlated significantly with scores on depression and anxiety self-rating scales, as well as with scores on a self-rating scale of posttraumatic stress disorder. Although the IES-R can be used for studying posttraumatic stress reactions in women who recently gave birth, the original IES proved to be a better instrument compared to the IES-R. It is concluded that adding the hyperarousal scale to the IES-R did not make the scale stronger.

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