scholarly journals Insights into Plant Extracellular ATP Signaling Revealed by the Discovery of an ATP-Regulated Transcription Factor

2020 ◽  
Vol 61 (4) ◽  
pp. 673-674
Author(s):  
Stephen Chivasa
Keyword(s):  
Transcription Factor ◽  
Extracellular Atp ◽  
Atp Signaling

Cyclic Nucleotide Gated Ion Channel 6 is involved in extracellular ATP signaling and plant immunity

2021 ◽  
Author(s):  
Ha N. Duong ◽  
Sung‐Hwan Cho ◽  
Limin Wang ◽  
An Q. Pham ◽  
Julia M. Davies ◽  
...  
Keyword(s):  
Ion Channel ◽  
Cyclic Nucleotide ◽  
Plant Immunity ◽  
Extracellular Atp ◽  
Atp Signaling

Extracellular ATP signaling in equine digital blood vessels

2013 ◽  
Vol 702 (1-3) ◽  
pp. 242-249 ◽  
Author(s):  
Hector Zerpa ◽  
Carol Crawford ◽  
Gillian E. Knight ◽  
Alice F. Fordham ◽  
Silvia E. Janska ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Extracellular Atp ◽  
Atp Signaling

scholarly journals Extracellular ATP signaling and homeostasis in plant cells

2012 ◽  
Vol 7 (5) ◽  
pp. 566-569 ◽  
Author(s):  
Jian Sun ◽  
Chunlan Zhang ◽  
Xuan Zhang ◽  
Shurong Deng ◽  
Rui Zhao ◽  
...  
Keyword(s):  
Plant Cells ◽  
Extracellular Atp ◽  
Atp Signaling

scholarly journals Chronic fructose renders pancreatic β-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling

2019 ◽  
Vol 317 (1) ◽  
pp. E25-E41 ◽  
Author(s):  
Clarissa Bartley ◽  
Thierry Brun ◽  
Lucie Oberhauser ◽  
Mariagrazia Grimaldi ◽  
Filippo Molica ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Atp Release ◽  
Extracellular Atp ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Cellular Mechanisms ◽  
Kinase Activation ◽  
Glucose Stimulated Insulin Secretion ◽  
Insulinoma Cells ◽  
Atp Signaling

Fructose is widely used as a sweetener in processed food and is also associated with metabolic disorders, such as obesity. However, the underlying cellular mechanisms remain unclear, in particular, regarding the pancreatic β-cell. Here, we investigated the effects of chronic exposure to fructose on the function of insulinoma cells and isolated mouse and human pancreatic islets. Although fructose per se did not acutely stimulate insulin exocytosis, our data show that chronic fructose rendered rodent and human β-cells hyper-responsive to intermediate physiological glucose concentrations. Fructose exposure reduced intracellular ATP levels without affecting mitochondrial function, induced AMP-activated protein kinase activation, and favored ATP release from the β-cells upon acute glucose stimulation. The resulting increase in extracellular ATP, mediated by pannexin1 (Panx1) channels, activated the calcium-mobilizer P2Y purinergic receptors. Immunodetection revealed the presence of both Panx1 channels and P2Y1 receptors in β-cells. Addition of an ectonucleotidase inhibitor or P2Y1 agonists to naïve β-cells potentiated insulin secretion stimulated by intermediate glucose, mimicking the fructose treatment. Conversely, the P2Y1 antagonist and Panx1 inhibitor reversed the effects of fructose, as confirmed using Panx1-null islets and by the clearance of extracellular ATP by apyrase. These results reveal an important function of ATP signaling in pancreatic β-cells mediating fructose-induced hyper-responsiveness.

scholarly journals Extracellular ATP signaling in plants

2010 ◽  
Vol 20 (10) ◽  
pp. 601-608 ◽  
Author(s):  
Kiwamu Tanaka ◽  
Simon Gilroy ◽  
Alan M. Jones ◽  
Gary Stacey
Keyword(s):  
Extracellular Atp ◽  
Atp Signaling

Extracellular ATP signaling and clinical relevance

2018 ◽  
Vol 188 ◽  
pp. 67-73 ◽  
Author(s):  
Lei Dou ◽  
Yi-Fa Chen ◽  
Peter J. Cowan ◽  
Xiao-Ping Chen
Keyword(s):  
Clinical Relevance ◽  
Extracellular Atp ◽  
Atp Signaling

Extracellular ATP and ADP Activate Transcription Factor NF-κB and Induce Endothelial Cell Apoptosis

1998 ◽  
Vol 248 (3) ◽  
pp. 822-829 ◽  
Author(s):  
Michaela von Albertini ◽  
Alois Palmetshofer ◽  
Elzbieta Kaczmarek ◽  
Katarzyna Koziak ◽  
Deborah Stroka ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Extracellular Atp ◽  
Endothelial Cell Apoptosis ◽  
Activate Transcription Factor

scholarly journals P2X-GCaMPs as versatile tools for imaging extracellular ATP signaling

eNeuro ◽  
2020 ◽  
pp. ENEURO.0185-20.2020
Author(s):  
Matthias Ollivier ◽  
Juline Beudez ◽  
Nathalie Linck ◽  
Thomas Grutter ◽  
Vincent Compan ◽  
...  
Keyword(s):  
Extracellular Atp ◽  
Atp Signaling
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