scholarly journals A Connectomic Atlas of the Human Cerebrum—Chapter 18: The Connectional Anatomy of Human Brain Networks

2018 ◽  
Vol 15 (suppl_1) ◽  
pp. S470-S480 ◽  
Author(s):  
Robert G Briggs ◽  
Andrew K Conner ◽  
Cordell M Baker ◽  
Joshua D Burks ◽  
Chad A Glenn ◽  
...  
Keyword(s):  
Network Modeling ◽  
Brain Networks ◽  
Network Models ◽  
Brain Surgery ◽  
Functional Magnetic Resonance ◽  
Novel Technologies ◽  
Fiber Tracts ◽  
Cortical Parcellation ◽  
Cortical Regions ◽  
And Task

ABSTRACT BACKGROUND It is widely understood that cortical functions are mediated by complex, interdependent brain networks. These networks have been identified and studied using novel technologies such as functional magnetic resonance imaging under both resting-state and task-based conditions. However, no one has attempted to describe these networks in terms of their cortical parcellations. OBJECTIVE To describe our approach to network modeling and discuss its significance for the future of neuronavigation in brain surgery using the cortical parcellation scheme detailed within this supplement. METHODS Using network models previously elucidated by our group using coordinate-based meta-analytic techniques, we show the anatomic position and underlying white matter tracts of the cortical regions comprising 8 functional networks of the human cerebrum. These network models are displayed using Synaptive's clinically available BrightMatter tractography software (Synaptive Medical, Toronto, Canada). RESULTS The relevant cortical parcellations of 8 different cerebral networks have been identified. The fiber tracts between these regions were used to construct anatomically precise models of the networks. Models are described for the dorsal attention, ventral attention, semantic, auditory, supplementary motor, ventral premotor, default mode, and salience networks. CONCLUSION Our goal is to move towards more precise, anatomically specific models of brain networks that can be constructed for individual patients and utilized in navigational platforms during brain surgery. We believe network modeling and future advances in navigation technology can provide a foundation for improving neurosurgical outcomes by allowing us to preserve complex brain networks.

scholarly journals On the structural connectivity of large-scale models of brain networks at cellular level

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Giuseppe Giacopelli ◽  
Domenico Tegolo ◽  
Emiliano Spera ◽  
Michele Migliore
Keyword(s):  
Large Scale ◽  
Brain Networks ◽  
Structural Connectivity ◽  
Network Models ◽  
Brain Regions ◽  
Cellular Level ◽  
Scale Model ◽  
Mathematical Framework ◽  
Underlying Mechanisms ◽  
Experimental Findings

AbstractThe brain’s structural connectivity plays a fundamental role in determining how neuron networks generate, process, and transfer information within and between brain regions. The underlying mechanisms are extremely difficult to study experimentally and, in many cases, large-scale model networks are of great help. However, the implementation of these models relies on experimental findings that are often sparse and limited. Their predicting power ultimately depends on how closely a model’s connectivity represents the real system. Here we argue that the data-driven probabilistic rules, widely used to build neuronal network models, may not be appropriate to represent the dynamics of the corresponding biological system. To solve this problem, we propose to use a new mathematical framework able to use sparse and limited experimental data to quantitatively reproduce the structural connectivity of biological brain networks at cellular level.

scholarly journals Investigating the Structure of Intelligence Using Latent Variable and Psychometric Network Modeling: A Commentary and Reanalysis

2021 ◽  
Vol 9 (1) ◽  
pp. 8
Author(s):  
Christopher J. Schmank ◽  
Sara Anne Goring ◽  
Kristof Kovacs ◽  
Andrew R. A. Conway
Keyword(s):  
Cognitive Processes ◽  
Latent Variable ◽  
Network Modeling ◽  
Network Models ◽  
Mental Ability ◽  
Variable Model ◽  
General Mental Ability ◽  
Theories Of Intelligence ◽  
Psychological Theories ◽  
Model Preference

In a recent publication in the Journal of Intelligence, Dennis McFarland mischaracterized previous research using latent variable and psychometric network modeling to investigate the structure of intelligence. Misconceptions presented by McFarland are identified and discussed. We reiterate and clarify the goal of our previous research on network models, which is to improve compatibility between psychological theories and statistical models of intelligence. WAIS-IV data provided by McFarland were reanalyzed using latent variable and psychometric network modeling. The results are consistent with our previous study and show that a latent variable model and a network model both provide an adequate fit to the WAIS-IV. We therefore argue that model preference should be determined by theory compatibility. Theories of intelligence that posit a general mental ability (general intelligence) are compatible with latent variable models. More recent approaches, such as mutualism and process overlap theory, reject the notion of general mental ability and are therefore more compatible with network models, which depict the structure of intelligence as an interconnected network of cognitive processes sampled by a battery of tests. We emphasize the importance of compatibility between theories and models in scientific research on intelligence.

scholarly journals Intolerance of uncertainty is associated with heightened responding in the prefrontal cortex during instructed threat of shock

2020 ◽  
Author(s):  
Jayne Morriss ◽  
Tiffany Bell ◽  
Nicolò Biagi ◽  
Tom Johnstone ◽  
Carien M. van Reekum
Keyword(s):  
Prefrontal Cortex ◽  
Anxiety Disorder ◽  
Intolerance Of Uncertainty ◽  
Neural Circuitry ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Prefrontal Cortical ◽  
Cortical Regions ◽  
Rostral Prefrontal Cortex ◽  
Threat Of Shock

AbstractHeightened responding to uncertain threat is associated with anxiety disorder pathology. Here, we sought to determine if individual differences in self-reported intolerance of uncertainty (IU) underlie differential recruitment of neural circuitry during instructed threat of shock (n = 42). During the task, cues signalled uncertain threat of shock (50%) or certain safety from shock. Ratings, skin conductance and functional magnetic resonance imaging was acquired. Overall, participants displayed greater amygdala activation to uncertain threat vs. safe cues, in the absence of an effect of IU. However, we found that high was associated with greater activity in the medial prefrontal cortex and dorsomedial rostral prefrontal cortex to uncertain threat vs safe cues. These findings suggest that, during instructed threat of shock, IU is specifically related, over trait anxiety, to activation in prefrontal cortical regions. Taken together, these findings highlight the potential of self-reported IU in identifying mechanisms that may be related to conscious threat appraisal and anxiety disorder pathology.

scholarly journals Dynamical differential covariance recovers directional network structure in multiscale neural systems

2021 ◽  
Author(s):  
Yusi Chen ◽  
Burke Q Rosen ◽  
Terrence J Sejnowski
Keyword(s):  
Structural Connectivity ◽  
Network Models ◽  
Ground Truth ◽  
Neural Systems ◽  
Noise Tolerance ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Dynamical Models ◽  
Wide Range ◽  
Neural Interactions

Investigating causal neural interactions are essential to understanding sub- sequent behaviors. Many statistical methods have been used for analyzing neural activity, but efficiently and correctly estimating the direction of net- work interactions remains difficult. Here, we derive dynamical differential covariance (DDC), a new method based on dynamical network models that detects directional interactions with low bias and high noise tolerance with- out the stationary assumption. The method is first validated on networks with false positive motifs and multiscale neural simulations where the ground truth connectivity is known. Then, applying DDC to recordings of resting-state functional magnetic resonance imaging (rs-fMRI) from over 1,000 individual subjects, DDC consistently detected regional interactions with strong structural connectivity. DDC can be generalized to a wide range of dynamical models and recording techniques.

Graph Theory-Based Brain Network Connectivity Analysis and Classification of Alzheimer’s Disease

2021 ◽  
Author(s):  
A. Thushara ◽  
C. Ushadevi Amma ◽  
Ansamma John
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Graph Theory ◽  
Neurodegenerative Disorder ◽  
Brain Networks ◽  
Network Connectivity ◽  
Brain Regions ◽  
Brain Network ◽  
Fiber Tracts ◽  
The Brain

Alzheimer’s Disease (AD) is basically a progressive neurodegenerative disorder associated with abnormal brain networks that affect millions of elderly people and degrades their quality of life. The abnormalities in brain networks are due to the disruption of White Matter (WM) fiber tracts that connect the brain regions. Diffusion-Weighted Imaging (DWI) captures the brain’s WM integrity. Here, the correlation betwixt the WM degeneration and also AD is investigated by utilizing graph theory as well as Machine Learning (ML) algorithms. By using the DW image obtained from Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, the brain graph of each subject is constructed. The features extracted from the brain graph form the basis to differentiate between Mild Cognitive Impairment (MCI), Control Normal (CN) and AD subjects. Performance evaluation is done using binary and multiclass classification algorithms and obtained an accuracy that outperforms the current top-notch DWI-based studies.

Bayesian Network Modeling of Transcription Factor Binding Sites

2007 ◽  
pp. 300-318
Author(s):  
Vipin Narang ◽  
Rajesh Chowdhary ◽  
Ankush Mittal ◽  
Wing-Kin Sung
Keyword(s):  
Transcription Factor ◽  
Parameter Estimation ◽  
Bayesian Network ◽  
Network Modeling ◽  
Network Models ◽  
Transcription Factor Binding Sites ◽  
Physical Problem ◽  
Network Applications ◽  
Bayesian Network Modeling ◽  
Bayesian Network Models

A predicament that engineers who wish to employ Bayesian networks to solve practical problems often face is the depth of study required in order to obtain a workable understanding of this tool. This chapter is intended as a tutorial material to assist the reader in efficiently understanding the fundamental concepts involved in Bayesian network applications. It presents a complete step by step solution of a bioinformatics problem using Bayesian network models, with detailed illustration of modeling, parameter estimation, and inference mechanisms. Considerations in determining an appropriate Bayesian network model representation of a physical problem are also discussed.

Integration of High Resolution EEG and Functional Magnetic Resonance in the Study of Human Movement-Related Potentials

2000 ◽  
Vol 39 (02) ◽  
pp. 179-182 ◽  
Author(s):  
F. Carducci ◽  
F. Cincotti ◽  
C. Del Gratta ◽  
G. M. Roberti ◽  
G. L. Romani ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Figure Of Merit ◽  
Human Movement ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Finger Extension ◽  
Eeg Data ◽  
Related Potentials ◽  
Standard Linear ◽  
Cortical Regions

Abstract:Cortical sources of human movement-related potentials (i.e. unilateral finger extension) were modeled using functional magnetic resonance imaging (fMR) data as a constraint of a linear inverse source estimation from highly sampled (128 channels) EEG data. Remarkably, this estimation was performed within realistic subject’s MR-constructed head models by boundary element techniques. An appropriate figure of merit served to set the optimal amount of fMR constraints. With respect to standard linear inverse source estimates, fMR-constrained ones presented increased spatial detail and provided a more reliable timing of activation in bilateral sensorimotor cortical regions of interest.

scholarly journals Frequency-based brain networks: From a multiplex framework to a full multilayer description

2018 ◽  
Vol 2 (4) ◽  
pp. 418-441 ◽  
Author(s):  
Javier M. Buldú ◽  
Mason A. Porter
Keyword(s):  
Brain Networks ◽  
Network Models ◽  
Real Data ◽  
Laplacian Matrix ◽  
Brain Regions ◽  
Brain Diseases ◽  
Multilayer Networks ◽  
Frequency Bands ◽  
Multiplex Network ◽  
The Brain

We explore how to study dynamical interactions between brain regions by using functional multilayer networks whose layers represent different frequency bands at which a brain operates. Specifically, we investigate the consequences of considering the brain as (i) a multilayer network, in which all brain regions can interact with each other at different frequency bands; and as (ii) a multiplex network, in which interactions between different frequency bands are allowed only within each brain region and not between them. We study the second-smallest eigenvalue λ2 of the combinatorial supra-Laplacian matrix of both the multiplex and multilayer networks, as λ2 has been used previously as an indicator of network synchronizability and as a biomarker for several brain diseases. We show that the heterogeneity of interlayer edge weights and, especially, the fraction of missing edges crucially modify the value of λ2, and we illustrate our results with both synthetic network models and real data obtained from resting-state magnetoencephalography. Our work highlights the differences between using a multiplex approach and a full multilayer approach when studying frequency-based multilayer brain networks.

A Weighted Network Modeling Approach for Analyzing Product Competition

2020 ◽  
Author(s):  
Yaxin Cui ◽  
Faez Ahmed ◽  
Zhenghui Sha ◽  
Lijun Wang ◽  
Yan Fu ◽  
...  
Keyword(s):  
Network Theory ◽  
Network Modeling ◽  
Network Models ◽  
Social Aspects ◽  
Exponential Random Graph Models ◽  
Graph Models ◽  
Random Graph Models ◽  
Exponential Random Graph ◽  
The Social ◽  
Product Competition

Abstract Statistical network models allow us to study the co-evolution between the products and the social aspects of a market system, by modeling these components and their interactions as graphs. In this paper, we study competition between different car models using network theory, with a focus on how product attributes (like fuel economy and price) affect which cars are considered together and which cars are finally bought by customers. Unlike past work, where most systems have been studied with the assumption that relationships between competitors are binary (i.e., whether a relationship exists or not), we allow relationships to take strengths (i.e., how strong a relationship is). Specifically, we use valued Exponential Random Graph Models and show that our approach provides a significant improvement over the baselines in predicting product co-considerations as well as in the validation of market share. This is also the first attempt to study aggregated purchase preference and car competition using valued directed networks.

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