scholarly journals Francisella tularensis bacteraemia causing multi-organ failure

2018 ◽  
Vol 2018 (9) ◽  
Author(s):  
Bent-Are Hansen ◽  
Rune Tilseth ◽  
Torgeir Finjord ◽  
Øyvind Bruserud
Keyword(s):  
Organ Failure ◽  
Francisella Tularensis ◽  
Multi Organ Failure

Thirty-eight-negative-kinase-1 is a major mediator of trauma-induced intestinal injury and multi-organ failure

2018 ◽  
Vol 56 (08) ◽  
pp. e205-e206
Author(s):  
M Armacki ◽  
AK Trugenberger ◽  
A Ellwanger ◽  
T Eiseler ◽  
L Bettac ◽  
...  
Keyword(s):  
Organ Failure ◽  
Intestinal Injury ◽  
Multi Organ Failure ◽  
Major Mediator

scholarly journals Simultaneous Occurrence of Choriocarcinoma in an Infant and Mother

2021 ◽  
Vol 18 (4) ◽  
pp. 1934
Author(s):  
Małgorzata Rzanny-Owczarzak ◽  
Joanna Sawicka-Metkowska ◽  
Katarzyna Jończyk-Potoczna ◽  
Ewelina Gowin ◽  
Patrycja Sosnowska-Sienkiewicz ◽  
...  
Keyword(s):  
Rare Disease ◽  
Organ Failure ◽  
Liver Tumor ◽  
Serum Levels ◽  
Simultaneous Occurrence ◽  
Positive History ◽  
Multi Organ Failure ◽  
History Of

Infantile choriocarcinoma is an extremely rare disease. We present a case study of a 1-month-old male with choriocarcinoma diagnosed simultaneously with his mother. On admission to hospital, the disease was very advanced and massive progression and multi-organ failure caused the death of the patient despite the implemented treatment. It was too late to save the child’s life, but early enough to save his mother. The authors believe that the serum levels of hCG should be determined in every newborn with anemia and liver tumor, especially when the mother has a positive history of miscarriage.

Multi-organ failure in adult onset Still’s disease: a septic disguise

2008 ◽  
Vol 28 (S1) ◽  
pp. 3-6 ◽  
Author(s):  
Paul R. J. Ames ◽  
Emily Walker ◽  
Darren Aw ◽  
David Marshall ◽  
Francois de Villiers ◽  
...  
Keyword(s):  
Organ Failure ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Multi Organ Failure ◽  
Adult Onset Still's Disease

Pathophysiology of Hemorrhage as It Relates to the Warfighter

Physiology ◽  
2022 ◽  
Author(s):  
Carmen Hinojosa-Laborde ◽  
Ian L. Hudson ◽  
Evan Ross ◽  
Lusha Xiang ◽  
Kathy L. Ryan
Keyword(s):  
Blood Transfusion ◽  
Organ Failure ◽  
Oxygen Delivery ◽  
Multi Organ Failure ◽  
Care Situation

Saving lives of wounded military Warfighters often depends on the ability to resolve or mitigate the pathophysiology of hemorrhage, specifically diminished oxygen delivery to vital organs that leads to multi-organ failure and death. However, caring for hemorrhaging patients on the battlefield presents unique challenges that extend beyond applying a tourniquet and giving a blood transfusion, especially when battlefield care must be provided for a prolonged period. This review will describe these challenges and potential strategies for treating hemorrhage on the battlefield in a prolonged casualty care situation.

scholarly journals Ceftizoxime-induced immune hemolytic anemia associated with multi-organ failure

2017 ◽  
Vol 34 (1) ◽  
pp. 123-127 ◽  
Author(s):  
Jin Young Huh ◽  
Ari Ahn ◽  
Hyungsuk Kim ◽  
Seog Woon Kwon ◽  
Sujong An ◽  
...  
Keyword(s):  
Organ Failure ◽  
Hemolytic Anemia ◽  
Multi Organ Failure ◽  
Immune Hemolytic Anemia

Time course of plasma and pulmonary lymph endothelin-like immunoreactivity during sustained endotoxaemia in chronically instrumented sheep

1991 ◽  
Vol 81 (3) ◽  
pp. 357-365 ◽  
Author(s):  
D. R. Morel ◽  
J. F. Pittet ◽  
K. Gunning ◽  
A. Hemsen ◽  
J. S. Lacroix ◽  
...  
Keyword(s):  
Septic Shock ◽  
Organ Failure ◽  
Thoracic Duct ◽  
Time Course ◽  
Reversed Phase ◽  
Left Ventricular ◽  
Endotoxin Infusion ◽  
Endothelin 1 ◽  
Multi Organ Failure ◽  
Conscious Sheep

1. Endothelin, a novel vasoconstrictor 21-residue peptide isolated from the supernatant of cultured porcine endothelial cells, has been shown to be increased in plasma in a variety of cardiovascular disease states, including acute myocardial infarction, acute renal failure and essential hypertension. We determined the time course of plasma and pulmonary lymph endothelin-like immunoreactivity in relation to the progressive deterioration of cardiopulmonary function in an ovine septic shock model leading to multi-organ failure syndrome and death within 42 h of a continuous intravenous infusion of Escherichia coli endotoxin (40 ng min−1 kg−1). 2. Plasma and pulmonary lymph endothelin-like immunoreactivity were measured by r.i.a. using a specific antiserum raised in rabbits against porcine endothelin-1. Endothelin-like immunoreactivity was further determined in lung tissue and the thoracic duct lymph of endotoxin-treated sheep by reversed-phase h.p.l.c. In control instrumented conscious sheep not infused with endotoxin, there were no significant changes in any of the measured cardiopulmonary and biochemical variables, with plasma and pulmonary lymph endothelin-like immunoreactivity remaining below the detection limit (< 1 pg/tube) throughout the 72 h study period. 3. Conscious sheep receiving endotoxin showed a major hypotensive septic syndrome, including persistently decreased systemic blood pressure, systemic vascular resistance, stroke volume, left ventricular stroke work, associated with sustained pulmonary vasoconstriction and protein-rich pulmonary oedema (> five-fold increase in pulmonary lymph flow and protein clearance), and marked lactic acidosis, leading to the death of animals within 14–42 h despite institution of mechanical ventilation and adequate intravascular volume replacement. 4. Appearance of endothelin-like immunoreactivity, as revealed by r.i.a., in arterial plasma and pulmonary lymph was simultaneous in both circulatory beds, with peak values measured between 4 and 12 h after the start of endotoxin infusion (plasma: 68 ± 8 pg/ml, pulmonary lymph: 88 ± 18 pg/ml, P < 0.05 compared with control sheep). After 12 h of endotoxaemia, endothelin-like immunoreactivity in both fluids progressively decreased up to the death of the animals, although remaining significantly above that measured in control sheep. The analysis of extracts of lung and thoracic duct by reversed-phase h.p.l.c. revealed that the r.i.a. method used in the present study mainly detected endothelin-1. 5. Our results demonstrate the presence of a marked and persistent increase in endothelin-like immunoreactivity in plasma and pulmonary lymph of sheep during lethal endotoxin shock with multi-organ failure, suggesting a continuous production and/or release of endothelin-1 into the pulmonary lymph and the systemic circulation upon continuous endotoxin infusion. These findings suggest that endothelin may contribute to the vasomotor disturbances observed during the development of septic shock, although studies using selective receptor antagonists or synthesis inhibitors are required to definitively confirm a potential pathophysiological role of endothelin during endotoxaemia.

scholarly journals COVID-19 pneumonitis induced myocardial infarction and multi-organ failure: an ethical and clinical challenge

2021 ◽  
Vol 3 (2) ◽  
pp. 01-04
Author(s):  
Susil Pallikadavath ◽  
Zakariyya Vali ◽  
Sanjay S Bhandari ◽  
Gerry P McCann
Keyword(s):  
Myocardial Infarction ◽  
Organ Failure ◽  
Late Presentation ◽  
Left Ventricular ◽  
Haemodynamic Instability ◽  
Acute Pulmonary Oedema ◽  
St Segment Elevation ◽  
Difficult Decision ◽  
Multi Organ Failure ◽  
Clinical Scenarios

A 62-year-old man presented at the height of the first wave of the coronavirus disease 2019 (COVID-19) pandemic with hypoxia, multi-organ failure and haemodynamic instability. The electrocardiogram and echocardiogram were indicative of inferolateral ST segment elevation myocardial infarction. His hypoxia was initially thought to be driven by acute pulmonary oedema due to cardiac failure, but this was out-of-proportion to his left-ventricular function. This aroused suspicion of COVID-19 which he subsequently tested positive for. He was not deemed to be candidate for primary percutaneous intervention, intubation or mechanical ventilation; a difficult decision to make in a previously healthy, young patient. Clinical decisions were complicated by late presentation and hospital pressures related to the pandemic. Similar clinical scenarios are likely as we move into the next stages of the pandemic. Establishing clinical frameworks to help clinicians make these decisions, and identifying barriers to healthcare attendance, may be priorities for policy-makers.

scholarly journals NATAL INJURIES OF VISCERAL ORGANS

2018 ◽  
Vol 63 (5) ◽  
pp. 197-201
Author(s):  
V. I. Morozov ◽  
A. A. Podshivalin ◽  
G. E. Chigvintsev ◽  
G. A. Yulmetov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Organ Failure ◽  
Clinical Case ◽  
Perinatal Period ◽  
Internal Organs ◽  
Visceral Organs ◽  
Multi Organ Failure

The article describes surgical diseases of newborns after a trauma of central nervous system in the perinatal period. There is a detailed diagnostic and therapeutic tactics for injuries of internal organs. There is a clinical case of natal injury, leading to severe multi-organ failure and death.

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