scholarly journals Effect of a Single Standard Dose (150–200 μg/kg) of Ivermectin onLoa loaMicrofilaremia: Systematic Review and Meta-analysis

2019 ◽  
Vol 6 (4) ◽  
Author(s):  
Sébastien D Pion ◽  
Jules Brice Tchatchueng-Mbougua ◽  
Cédric B Chesnais ◽  
Joseph Kamgno ◽  
Jacques Gardon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Standard Dose ◽  
Meta Analysis ◽  
Single Standard

scholarly journals Reduction of biologics in rheumatoid arthritis treatment

2019 ◽  
Author(s):  
Leticia Breda e Vasconcelos ◽  
Tais Freire Galvao
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Relative Risk ◽  
Disease Activity ◽  
Clinical Outcomes ◽  
Standard Dose ◽  
Meta Analysis ◽  
Biological Drugs ◽  
Low Disease Activity ◽  
Standardized Mean Difference

This systematic review assesses the effectiveness and safety of reducing the dose of biological drugs in patients with rheumatoid arthritis at low disease activity, compared to standard dose treatment. Clinical outcomes data were collected and summarized in meta-analysis of standardized mean difference or relative risk. Most outcomes were non-significant.

High versus standard dose caffeine for apnoea: a systematic review

2018 ◽  
Vol 103 (6) ◽  
pp. F523-F529 ◽  
Author(s):  
Roos Vliegenthart ◽  
Martijn Miedema ◽  
Gerard J Hutten ◽  
Anton H van Kaam ◽  
Wes Onland
Keyword(s):  
Systematic Review ◽  
Standard Dose ◽  
Meta Analysis ◽  
Neurodevelopmental Outcome ◽  
Optimal Dose ◽  
Controlled Trials ◽  
Level Of Evidence ◽  
Assessment Development ◽  
Postmenstrual Age ◽  
Randomised Controlled

BackgroundPlacebo-controlled trials have shown that caffeine is highly effective in treating apnoea of prematurity and reduces the risk of bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI).ObjectiveTo identify, appraise and summarise studies investigating the modulating effect of different caffeine dosages.MethodsA systematic review identified all randomised controlled trials (RCTs) comparing a high versus a standard caffeine treatment regimen in infants with a gestational age <32 weeks, by searching the main electronic databases and abstracts of the Pediatric Academic Societies. Studies comparing caffeine to placebo or theophylline only were excluded. Primary outcomes were BPD and mortality at 36 weeks postmenstrual age. Secondary key-outcome was neurodevelopmental outcome at 12 and 24 months corrected age. Meta-analysis was performed using RevMan 5.3.ResultsSix RCTs including 620 infants were identified. Meta-analysis showed a significant decrease in BPD, the combined outcome BPD or mortality, and failure to extubate in infants allocated to a higher caffeine dose. No differences were found in mortality alone and NDI. The quality of the outcome measures were deemed low to very low according to the Grading of Recommendations Assessment, Development and Evaluation guidelines.ConclusionsAlthough this review suggests that administering a higher dose of caffeine might enhance its beneficial effect on death or BPD, firm recommendations on the optimal caffeine dose cannot be given due to the low level of evidence. A large RCT is urgently needed to confirm or refute these findings and determine the optimal dose of caffeine.

LOW DOSE VS. STANDARD DOSE OF ANTIPSYCHOTICS FOR RELAPSE PREVENTION IN SCHIZOPHRENIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

2010 ◽  
Vol 117 (2-3) ◽  
pp. 503-504
Author(s):  
Hiroyuki Uchida ◽  
Takefumi Suzuki ◽  
Hiroyoshi Takeuchi ◽  
Tamara Arenovich ◽  
David C. Mamo
Keyword(s):  
Systematic Review ◽  
Relapse Prevention ◽  
Low Dose ◽  
Standard Dose ◽  
Meta Analysis
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