scholarly journals Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Julia A. Messina ◽  
Eileen K. Maziarz ◽  
Andrej Spec ◽  
Dimitrios P. Kontoyiannis ◽  
John R. Perfect
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Involvement ◽  
Potential Complication ◽  
System Involvement ◽  
Lymphoid Malignancies ◽  
Brain Involvement

Abstract We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system mycoses should be considered as a potential complication of ibrutinib.

CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement

2006 ◽  
Vol 397 (1-2) ◽  
pp. 145-148 ◽  
Author(s):  
Linda M.P. le Blanc ◽  
Antoine W.T. van Lieshout ◽  
Gosse J. Adema ◽  
Piet L.C.M. van Riel ◽  
Marcel M. Verbeek ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Involvement ◽  
System Involvement ◽  
Inflammatory Conditions
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