scholarly journals Symptoms of Autonomic Dysfunction in Human Immunodeficiency Virus

2015 ◽  
Vol 2 (3) ◽  
Author(s):  
Dominic Chow ◽  
Beau K. Nakamoto ◽  
Katherine Sullivan ◽  
David M. Sletten ◽  
Satomi Fujii ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Retrospective Study ◽  
Antiretroviral Therapy ◽  
Sexual Dysfunction ◽  
Autonomic Dysfunction ◽  
Immunodeficiency Virus ◽  
Combined Antiretroviral Therapy ◽  
Male Sexual Dysfunction ◽  
Hiv Negative

Abstract This retrospective study evaluated the frequencies of symptoms associated with autonomic dysfunction in human immunodeficiency virus (HIV)-infected patients on stable combined antiretroviral therapy. Patients infected with HIV reported higher frequencies of dysautonomia symptoms compared with HIV-negative patients, particularly in the autonomic domains related to urinary, sleep, gastroparesis, secretomotor, pupillomotor, and male sexual dysfunction.

scholarly journals Occurrence of Accelerated Epigenetic Aging and Methylation Disruptions in Human Immunodeficiency Virus Infection Before Antiretroviral Therapy

2020 ◽  
Author(s):  
Chen Xi Yang ◽  
Emma Schon ◽  
Ma’en Obeidat ◽  
Michael S Kobor ◽  
Lisa McEwen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Cellular Aging ◽  
Epigenetic Clock ◽  
Cell Counts ◽  
Immunodeficiency Virus ◽  
Negative Controls ◽  
Hiv Negative

Abstract Background Whether accelerated aging develops over the course of chronic human immunodeficiency virus (HIV) infection or can be observed before significant immunosuppression on is unknown. We studied DNA methylation in blood to estimate cellular aging in persons living with HIV (PLWH) before the initiation of antiretroviral therapy (ART). Methods A total of 378 ART-naive PLWH who had CD4 T-cell counts >500/µL and were enrolled in the Strategic Timing of Antiretroviral Therapy trial (Pulmonary Substudy) were compared with 34 HIV-negative controls. DNA methylation was performed using the Illumina MethylationEPIC BeadChip. Differentially methylated positions (DMPs) and differentially methylated regions (DMRs) in PLWH compared with controls were identified using a robust linear model. Methylation age was calculated using a previously described epigenetic clock. Results There were a total of 56 639 DMPs and 6103 DMRs at a false discovery rate of <0.1. The top 5 DMPs corresponded to genes NLRC5, VRK2, B2M, and GPR6 and were highly enriched for cancer-related pathways. PLWH had significantly higher methylation age than HIV-negative controls (P = .001), with black race, low CD4 and high CD8 T-cell counts, and duration of HIV being risk factors for age acceleration. Conclusions PLWH before the initiation of ART and with preserved immune status show evidence of advanced methylation aging.

scholarly journals Cardiovascular Autonomic Dysfunction in Africans Infected with Human Immunodeficiency Virus

2002 ◽  
Vol 95 (9) ◽  
pp. 445-447 ◽  
Author(s):  
Divine Nzuobontane ◽  
Blackett Kathleen Ngu ◽  
Kuaban Christopher
Keyword(s):  
Blood Pressure ◽  
Human Immunodeficiency Virus ◽  
Autonomic Dysfunction ◽  
Hiv Positive ◽  
Cardiovascular Autonomic Dysfunction ◽  
Hiv Test ◽  
Immunodeficiency Virus ◽  
Blood Pressure Responses ◽  
African Patients ◽  
Hiv Negative

The effects of human immunodeficiency virus (HIV) on cardiovascular autonomic function have been little investigated in African patients. We performed standard heart-rate and blood pressure tests on 75 consecutive consenting patients referred for an HIV test in Yaounde, Cameroon. 54 patients proved to be HIV-infected (30 having progressed to AIDS). Cardiovascular autonomic dysfunction was present in 8 (28%) patients with AIDS and in 1 (4%) HIV-positive patient without AIDS; no HIV-negative individuals had abnormal results. If borderline results are included, over 80% of HIV-positive patients had cardiovascular autonomic dysfunction. In HIV-infected patients, simple tests such as blood pressure responses to standing or handgrip can warn of cardiovascular autonomic dysfunction, thus signalling the need for added precautions when invasive procedures are proposed.

scholarly journals Evaluation of Kidney Function Tests in HIV-Positive Patients Receiving Combined Antiretroviral Therapy

2021 ◽  
Author(s):  
emre aydın ◽  
Fatma Yılmaz Aydın ◽  
Yakup Demir ◽  
Yaşar Yıldırım ◽  
Mustafa Kemal Çelen
Keyword(s):  
Human Immunodeficiency Virus ◽  
Glomerular Filtration Rate ◽  
Antiretroviral Therapy ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Hiv Positive ◽  
Group 4 ◽  
Immunodeficiency Virus ◽  
Combined Antiretroviral Therapy ◽  
Group 5

Introduction: Human Immunodeficiency virus is a chronic infection that attacks the immune system of the human body, particularly CD4 T lymphocytes. Combined antiretroviral therapies are highly effective in virological suppression of human immunodeficiency virus infection. It has been shown that some retroviral therapies have a higher nephrotoxicity potential. As a result of renal injury, serum creatinine increases, and the estimated glomerular filtration rate is reduced. The aim of our study was to assess changes in kidney function during a 24-month period in HIV-positive patients who were begun on combined antiretroviral therapy. Material-method: A total of 127 HIV positive patients were enrolled. The patients were divided into five groups; patients who received no therapy were designated as Group 1; those that received Dolutegravir/Abacavir/Lamivudine combination as Group 2; those that received Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Fumarate combination as Group 3; those that received Emtricitabine/Tenofovir Disoproxil Fumarate/Dolutegravir combination as Group 4; and those that received Emtricitabine/Tenofovir Disoproxil Fumarate/Raltegravir combination as Group 5. We compared the effects of these drugs on estimated glomerular filtration rate during a 24-month follow-up period. Results: At the 24th month of therapy, a significant difference was observed between the eGFR levels of the study groups (p:<0.001). eGFR level was significantly higher in Group 4 compared to Groups 1, 2, and 3 (p:0.009, p:<0.001, p:<0.001, respectively) while it was significantly lower in Group 5 than groups 1, 2, and 3 (p:0.005, p:<0.001, p:<0.001, respectively). No significant eGFR difference was found between Group 4 and Group 5 (p>0.05). Serum creatinine level was significantly higher in Groups 4 and 5 compared to the other groups (p<0.001). Conclusion: The use of TDF-containing regimens causes renal dysfunction. Therefore, we recommend close monitoring of renal function, especially in patients treated with TDF.

Sign in / Sign up

Export Citation Format

Share Document