scholarly journals Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study

2021 ◽  
Vol 8 (12) ◽  
Author(s):  
Timothy M Rawson ◽  
Richard C Wilson ◽  
Luke S P Moore ◽  
Alasdair P Macgowan ◽  
Andrew M Lovering ◽  
...  
Keyword(s):  
Steady State ◽  
Healthy Volunteer ◽  
Serum Concentrations ◽  
Base Population ◽  
Penicillin V ◽  
Volunteer Study ◽  
Population Pk ◽  
Healthy Volunteer Study

Abstract This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data.

scholarly journals Steady-state 4D flow using double gating: a healthy volunteer study

2015 ◽  
Vol 17 (S1) ◽  
Author(s):  
Stanislas Rapacchi ◽  
Yutaka Natsuaki ◽  
Paul J Finn ◽  
Gerhard Laub ◽  
Daniel B Ennis ◽  
...  
Keyword(s):  
Steady State ◽  
Healthy Volunteer ◽  
4D Flow ◽  
Volunteer Study ◽  
Healthy Volunteer Study

scholarly journals Pharmacokinetics of Lopinavir in HIV-Infected Adults Receiving Rifampin with Adjusted Doses of Lopinavir-Ritonavir Tablets

2011 ◽  
Vol 55 (7) ◽  
pp. 3195-3200 ◽  
Author(s):  
Eric H. Decloedt ◽  
Helen McIlleron ◽  
Peter Smith ◽  
Concepta Merry ◽  
Catherine Orrell ◽  
...  
Keyword(s):  
Steady State ◽  
Healthy Volunteer ◽  
Tablet Formulation ◽  
Double Dose ◽  
Capsule Formulation ◽  
Time Curve ◽  
Concentration Time ◽  
Volunteer Study ◽  
Healthy Volunteer Study ◽  
Grade 3

ABSTRACTRifampin coadministration dramatically reduces plasma lopinavir (LPV) concentrations. In healthy volunteers, doubling the dose of a lopinavir-ritonavir (LPV/r) capsule formulation overcame this interaction, but a subsequent study of double doses of the tablet formulation was stopped early owing to hepatotoxicity. However, healthy-volunteer study findings may not apply to HIV-infected adults. We evaluated the steady-state pharmacokinetics of LPV in HIV-infected adults virologically suppressed on an LPV/r regimen who were given rifampin, and the dose of the LPV/r tablet formulation was gradually increased. The steady-state pharmacokinetics of LPV/r were evaluated at baseline, a week after commencing rifampin, a week after the LPV/r dose was increased 1.5 times, and a week after the LPV/r dose was doubled. Twenty-one participants were enrolled. The median [interquartile range (IQR)] predose LPV concentrations (C0) were 8.1 (6.2 to 9.8) mg/liter at baseline, 1.7 (0.3 to 3.0) mg/liter after 7 days of rifampin, 5.9 (2.1 to 9.9) mg/liter with 1.5 times the dose of LPV/r, and 10.8 (7.0 to 13.1) mg/liter with double-dose LPV/r. There were no significant differences in the LPV area under the plasma concentration-time curve from 0 to 12 h (AUC0-12),C0,C12, maximum concentration of drug in serum (Cmax), or half-life (t1/2) between the baseline and double-dose LPV/r time points. Treatment was generally well tolerated, with two participants developing asymptomatic grade 3/4 transaminitis. Doubling the dose of the tablet formulation of LPV/r overcomes induction by rifampin. Less hepatotoxicity occurred in our cohort of HIV-infected participants than was reported in healthy-volunteer studies.

Management of hyperglycemia associated with pasireotide (SOM230): Healthy volunteer study

2014 ◽  
Vol 103 (3) ◽  
pp. 458-465 ◽  
Author(s):  
Astrid Breitschaft ◽  
Ke Hu ◽  
Karina Hermosillo Reséndiz ◽  
Christelle Darstein ◽  
Georg Golor
Keyword(s):  
Healthy Volunteer ◽  
Volunteer Study ◽  
Healthy Volunteer Study

Abstract A57: High‐dose resveratrol modulates drug and carcinogen metabolizing enzymes in a healthy volunteer study

2010 ◽  
Author(s):  
H‐H Sherry Chow ◽  
Linda Garland ◽  
Chiu‐Hsieh Hsu ◽  
Donna Vining ◽  
Wade Chew ◽  
...  
Keyword(s):  
Healthy Volunteer ◽  
High Dose ◽  
Metabolizing Enzymes ◽  
Volunteer Study ◽  
Healthy Volunteer Study

Effects of Spicy Stimulation and Spicy-Food Consumption on Human Pain Sensitivity: A Healthy Volunteer Study

2020 ◽  
Vol 21 (7-8) ◽  
pp. 848-857
Author(s):  
Guangyou Duan ◽  
Zhuoxi Wu ◽  
Zhenxin Duan ◽  
Guiying Yang ◽  
Liang Fang ◽  
...  
Keyword(s):  
Healthy Volunteer ◽  
Food Consumption ◽  
Pain Sensitivity ◽  
Spicy Food ◽  
Volunteer Study ◽  
Healthy Volunteer Study

Randomized Phase I Healthy Volunteer Study of UTTR 1147A ( IL ‐22Fc): A Potential Therapy for Epithelial Injury

2018 ◽  
Vol 105 (1) ◽  
pp. 177-189 ◽  
Author(s):  
Michael E. Rothenberg ◽  
Yehong Wang ◽  
Annemarie Lekkerkerker ◽  
Dimitry M. Danilenko ◽  
Romeo Maciuca ◽  
...  
Keyword(s):  
Healthy Volunteer ◽  
Phase I ◽  
Epithelial Injury ◽  
Volunteer Study ◽  
Healthy Volunteer Study
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