Alarming tuberculosis rate among people who inject drugs in Vietnam
Abstract Background The tuberculosis (TB) epidemic is not homogeneous in the general population but presents high-risk groups. People who inject drugs (PWID) are such a group. However, TB among PWID remains largely undocumented. Our goal was to assess the prevalence of TB and the risk factors associated with TB among PWID in Vietnam. Methods We implemented a cross-sectional survey among two community-based cohorts of HIV-positive and HIV-negative PWID in Hai Phong. Participants were screened for TB using questions on TB symptoms. Those who reported any symptom were accompanied by peers to the TB clinic for chest X-Ray. If the latter was abnormal, a sputum was collected to perform an Xpert® MTB/RIF test. Results 885 PWID were screened for TB. For both cohorts, most PWID were male (>90.0%), with a median age of 42 years. Beside heroin injection, 52.5% of participants reported smoking methamphetamine, and 63.2% were on methadone. Among HIV-positive PWID (N=451), 90.4% were on antiretroviral therapy and 81.6% had a viral load <1,000 copies/mL. Using a complete-case analysis, the estimated TB prevalence was 2.3% (95%CI: 1.0-4.5) and 2.1% (95%CI: 0.8-4.2) among HIV-positives and HIV-negatives, respectively. Living in couple, arrest over the past six months, homelessness and smoking methamphetamine were independently associated with TB but not HIV infection. Conclusions In a context of very large antiretroviral therapy coverage, this extremely high rate of TB among PWID requires urgent actions.