scholarly journals The Relationship Between Hepatitis C Virus Rates and Office-Based Buprenorphine Access in Ohio

2021 ◽  
Author(s):  
Daniel L Brook ◽  
Angela T Hetrick ◽  
Shibani R Chettri ◽  
Christine A Schalkoff ◽  
Adams L Sibley ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
The Relationship

scholarly journals Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies

2008 ◽  
Vol 82 (24) ◽  
pp. 12020-12029 ◽  
Author(s):  
Joe Grove ◽  
Søren Nielsen ◽  
Jin Zhong ◽  
Margaret F. Bassendine ◽  
Heidi E. Drummer ◽  
...  
Keyword(s):  
Cell Culture ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Neutralizing Antibodies ◽  
Particle Density ◽  
Gradient Centrifugation ◽  
Scavenger Receptor ◽  
Scavenger Receptor Bi ◽  
Host Immune Responses ◽  
The Relationship

ABSTRACT Hepatitis C virus (HCV) infection is dependent on at least three coreceptors: CD81, scavenger receptor BI (SR-BI), and claudin-1. The mechanism of how these molecules coordinate HCV entry is unknown. In this study we demonstrate that a cell culture-adapted JFH-1 mutant, with an amino acid change in E2 at position 451 (G451R), has a reduced dependency on SR-BI. This altered receptor dependency is accompanied by an increased sensitivity to neutralization by soluble CD81 and enhanced binding of recombinant E2 to cell surface-expressed and soluble CD81. Fractionation of HCV by density gradient centrifugation allows the analysis of particle-lipoprotein associations. The cell culture-adapted mutation alters the relationship between particle density and infectivity, with the peak infectivity occurring at higher density than the parental virus. No association was observed between particle density and SR-BI or CD81 coreceptor dependence. JFH-1 G451R is highly sensitive to neutralization by gp-specific antibodies, suggesting increased epitope exposure at the virion surface. Finally, an association was observed between JFH-1 particle density and sensitivity to neutralizing antibodies (NAbs), suggesting that lipoprotein association reduces the sensitivity of particles to NAbs. In summary, mutation of E2 at position 451 alters the relationship between particle density and infectivity, disrupts coreceptor dependence, and increases virion sensitivity to receptor mimics and NAbs. Our data suggest that a balanced interplay between HCV particles, lipoprotein components, and viral receptors allows the evasion of host immune responses.

scholarly journals A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Hirayuki Enomoto ◽  
Nobuhiro Aizawa ◽  
Hideji Nakamura ◽  
Ryo Takata ◽  
Yoshiyuki Sakai ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Liver Function ◽  
Glycated Hemoglobin ◽  
Glycated Albumin ◽  
Albumin Level ◽  
Metabolic Variables ◽  
Branched Chain ◽  
The Relationship

Background. Only a few biomarkers based on metabolic parameters for evaluating liver fibrosis have been reported. The aim of this study was to investigate the relevance of an index obtained from three metabolic variables (glycated albumin: GA, glycated hemoglobin: HbA1c, and branched-chain amino acids to tyrosine ratio: BTR) to the degree of liver fibrosis in hepatitis C virus virus- (HCV-) positive patients.Methods. A total of 394 HCV-positive patients were assessed based on the values of a new index (GA/HbA1c/BTR). The index findings were used to investigate the relationship with the degree of liver fibrosis.Results. The new index showed an association with the stage of fibrosis (METAVIR scores: F0-1: 0.42 ± 0.10, F2: 0.48 ± 0.15, F3: 0.56 ± 0.22, and F4: 0.71 ± 0.30). The index was negatively correlated with three variables of liver function: the prothrombin time percentage (P<0.0001), albumin level (P<0.0001), and cholinesterase level (P<0.0001). The new index showed a higher correlation related to liver function than FIB-4 and the APRI did. In addition, the index showed a higher AUROC value than that of FIB-4 and the APRI for prediction of liver cirrhosis.Conclusion. The new metabolism-related index, GA/HbA1c/BTR value, is shown to relate to the degree of liver fibrosis in HCV-positive patients.

scholarly journals The Relationship between Virological Characteristics of Hepatitis C Virus HCV and Reactivity to the Regional Specific Proteins of HCV

2000 ◽  
Vol 15 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Seung Kew Yoon ◽  
Young Min Park ◽  
Byung Hoon Byun ◽  
Si Hyun Bae ◽  
Jin Mo Yang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Specific Proteins ◽  
The Relationship

scholarly journals Deciphering the Relationship Between Hepatitis C Virus (HCV) P7 and Its Foes

2010 ◽  
Vol 98 (3) ◽  
pp. 654a
Author(s):  
Chee Foong Chew ◽  
Nicole Zitzmann ◽  
Philip C. Biggin
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
The Relationship

The Impact of Hepatitis C Virus Infection on Buprenorphine Dose in Pregnancy

2019 ◽  
Vol 37 (01) ◽  
pp. 073-078
Author(s):  
Misty L. McDowell ◽  
Tiffany R. Tonismae ◽  
James E. Slaven ◽  
Mary P. Abernathy ◽  
Anthony L. Shanks ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Liver Enzymes ◽  
Hcv Infection ◽  
Third Trimester ◽  
Correlation Tests ◽  
The Impact ◽  
The Relationship ◽  
In Pregnancy

Abstract Objective Buprenorphine (BUP) is commonly used for opioid maintenance therapy in pregnancy. Our goal was to determine whether liver dysfunction related to hepatitis C virus (HCV) infection impacts BUP dosing requirements in pregnancy. Study Design This was a retrospective cohort study of pregnant women with antenatal exposure to BUP to compare dosing between individuals positive versus negative for HCV infection. Spearman correlation tests were used to assess the relationship between BUP dose and HCV status. Results HCV infection was present in 103 (39%) of the patients. Patients with HCV infection required lower dose increases of BUP throughout pregnancy (p = 0.02). HCV viral load was positively correlated with the liver enzymes aspartate transaminase (r = 0.30, p = 0.003) and alanine transaminase (r = 0.25, p = 0.01). There was a negative correlation between HCV viral load and BUP dose during the second trimester (r = −0.27, p = 0.01) and third trimester (r = −0.20, p = 0.04). Conclusion Women with HCV infection required less of an increase in BUP dose throughout pregnancy compared with women without HCV infection. Severity of HCV infection, as measured by viral load and liver enzymes, was also associated with BUP dosing.

Examination of the Relationship between the Hepatitis C Virus and Behçet's Disease

2004 ◽  
Vol 31 (5) ◽  
pp. 442-443 ◽  
Author(s):  
Meral Sönmezoglu ◽  
Emine Derviş ◽  
Selim Badur ◽  
O.Şadi Yenen
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
The Relationship
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