scholarly journals Can’t Work from Home: Pooled Nucleic Acid Testing of Laboratory Workers During The COVID-19 Pandemic

2021 ◽  
Author(s):  
Stephen A Rawlings ◽  
Brianna Scott ◽  
Laura Layman ◽  
Pramod Naranatt ◽  
Roy Heltsley ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Working Environment ◽  
Nucleic Acid Testing ◽  
Testing Strategy ◽  
Protective Measures ◽  
Work From Home ◽  
Returning To Work ◽  
Margin Of Safety ◽  
Laboratory Workers ◽  
Safe Working

Abstract Together with protective measures, routine screening for SARS-CoV-2 infection help provide a safe working environment. We evaluated a pooled nucleic acid testing strategy in a research laboratory. It allowed to maintain its activity and would save 25,920 person-hours and $1,684,800/year by increasing the margin of safety for returning to work.

Pooled nucleic acid testing strategy for monitoring HIV-1 treatment in resource limited settings

2019 ◽  
Vol 117 ◽  
pp. 56-60 ◽  
Author(s):  
Boobalan J ◽  
Dinesha TR ◽  
Gomathi S ◽  
Elakkiya E ◽  
Pradeep A ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Testing ◽  
Testing Strategy ◽  
Resource Limited Settings ◽  
Resource Limited ◽  
Hiv 1

scholarly journals Does Employee Care Trigger Innovation Under a Healthy and Safe Working Environment? Evidence from the Pharmaceutical Industry in China

Healthcare ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 194
Author(s):  
Minghui Yang ◽  
Qian Lin ◽  
Petra Maresova
Keyword(s):  
Safety Management ◽  
Positive Impact ◽  
Health And Safety ◽  
Working Environment ◽  
Firm Innovation ◽  
Corporate Managers ◽  
Pharmaceutical Firms ◽  
Corporate Ability ◽  
Safe Working

Sustainability of the workforce becomes a crucial issue, of which responsible care for employees can increase job satisfaction and human capital that impact corporate ability to absorb and generate new knowledge. Firms are obligated to provide a healthy and safe working environment for their employees, but it may in turn hinder innovation due to rigid and structured institutional regulations. Drawing on data of 308 China’s pharmaceutical firms from 2010 to 2017, we investigated whether employee care can trigger innovation under corporate adoption of the occupational health and safety management system (OHSMS). Our results suggest that both employee care and OHSMS adoption have a positive impact on innovation. Moreover, the positive relationship between employee care and innovation was more pronounced in firms that had adopted the OHSMS certification. These findings are valuable to policymakers and corporate managers in emerging economies through corroborating the important role of workforce sustainability in facilitating firm innovation.

scholarly journals Recognize Yourself—Innate Sensing of Non-LTR Retrotransposons

Viruses ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 94
Author(s):  
Justine Lagisquet ◽  
Kilian Zuber ◽  
Thomas Gramberg
Keyword(s):  
Pattern Recognition ◽  
Nucleic Acid ◽  
Autoimmune Diseases ◽  
Ltr Retrotransposons ◽  
Autoinflammatory Disorders ◽  
Protective Measures ◽  
Active Elements ◽  
Enhanced Expression ◽  
Long Interspersed Element

Although mobile genetic elements, or transposons, have played an important role in genome evolution, excess activity of mobile elements can have detrimental consequences. Already, the enhanced expression of transposons-derived nucleic acids can trigger autoimmune reactions that may result in severe autoinflammatory disorders. Thus, cells contain several layers of protective measures to restrict transposons and to sense the enhanced activity of these “intragenomic pathogens”. This review focuses on our current understanding of immunogenic patterns derived from the most active elements in humans, the retrotransposons long interspersed element (LINE)-1 and Alu. We describe the role of known pattern recognition receptors in nucleic acid sensing of LINE-1 and Alu and the possible consequences for autoimmune diseases.

Elevated white blood cell count does not predict Clostridium difficile nucleic acid testing results

2021 ◽  
Author(s):  
Dustin E Bosch ◽  
Patrick C Mathias ◽  
Niklas Krumm ◽  
Andrew Bryan ◽  
Ferric C Fang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Clostridium Difficile ◽  
Blood Cell ◽  
Cell Count ◽  
Prognostic Marker ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Inpatient Setting ◽  
Nucleic Acid Testing ◽  
Blood Cell Count

Abstract Background An elevated white blood cell count (>15 thousand/μL) is an established prognostic marker in patients with Clostridium difficile infection (CDI). Small observational studies have suggested that a markedly elevated WBC should prompt consideration of CDI. However, there is limited evidence correlating WBC elevation with the results of C. difficile nucleic acid testing (NAAT). Methods Retrospective review of laboratory testing, outcomes, and treatment of 16,568 consecutive patients presenting to 4 hospitals over four years with NAAT and WBC testing on the same day. Results No significant relationship between C. difficile NAAT results and concurrent WBC in the inpatient setting was observed. Although an elevated WBC did predict NAAT results in the outpatient and emergency department populations (p<0.001), accuracy was poor, with receiver-operator areas under the curve of 0.59 and 0.56. An elevated WBC (>15 thousand/μL) in CDI was associated with a longer median hospital length of stay (15.5 vs. 11.0 days, p<0.01), consistent with leukocytosis as a prognostic marker in CDI. NAAT-positive inpatients with elevated WBC were more likely to be treated with metronidazole and/or vancomycin (relative ratio 1.2, 95% confidence interval 1.1–1.3) and die in the hospital (relative ratio 2.9, 95% CI 2.0–4.3). Conclusions Although WBC is an important prognostic indicator in patients with CDI, an isolated WBC elevation has low sensitivity and specificity as a predictor of fecal C. difficile NAAT positivity in the inpatient setting. A high or rising WBC in isolation is not a sufficient indication for CDI testing.

scholarly journals Comprehensive large-scale nucleic acid–testing strategies support China’s sustained containment of COVID-19

2021 ◽  
Author(s):  
Zhongjie Li ◽  
Fengfeng Liu ◽  
Jinzhao Cui ◽  
Zhibin Peng ◽  
Zhaorui Chang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Large Scale ◽  
Nucleic Acid Testing ◽  
Testing Strategies
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