scholarly journals Evaluation of 2 Lateral Flow Rapid Tests in the Diagnosis of Chagas Disease in the Washington Metropolitan Area

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Yagahira E Castro-Sesquen ◽  
Antonella Saldaña ◽  
Dhayanna Patino Nava ◽  
Diana Paulette Evans ◽  
Tabitha Bayangos ◽  
...  
Keyword(s):  
Latent Class Analysis ◽  
Chagas Disease ◽  
Metropolitan Area ◽  
Latent Class ◽  
Lateral Flow ◽  
Hispanic Immigrants ◽  
Diverse Populations ◽  
Class Analysis ◽  
Rapid Tests

Abstract We compared the accuracy of the Stat-Pak and Chagas Detect Plus with a latent class analysis. Sensitivity values of 89.7% and 91.9% and specificities of 97.1% and 80.3%, respectively, were seen in the serodiagnosis of Chagas disease in Hispanic immigrants, revealing the limitations of these tests in diverse populations.

scholarly journals Use of a Latent Class Analysis in the diagnosis of chronic Chagas disease in the Washington Metropolitan area

2020 ◽  
Author(s):  
Yagahira E Castro-Sesquen ◽  
Antonella Saldaña ◽  
Dhayanna  Patino Nava ◽  
Tabitha Bayangos ◽  
Diana Paulette Evans ◽  
...  
Keyword(s):  
South America ◽  
Latent Class Analysis ◽  
Metropolitan Area ◽  
Latent Class ◽  
Main Type ◽  
Class Analysis ◽  
Predictive Values ◽  
Secretory Antigen ◽  
Antibody Levels ◽  
The U.S

Abstract Background The diversity of individuals at risk for Trypanosoma cruzi infection in the U.S. poses challenges for diagnosis. We evaluated the diagnostic accuracy of FDA-cleared tests in the Washington Metropolitan area (WMA). Methods 1514 individuals living were evaluated (1078 from Mexico, Central and northern South America [TcI-predominant areas], and 436 from southern South America [TcII/V/VI-predominant areas]). OD values from the Hemagen EIA and Chagatest v.3 Wiener, and categorical results of the IgG-TESA-blot (Western Blot with Trypomastigote Excretory-Secretory Antigen), and the Chagas Detect Plus (CDP), as well as information of area of origin were used to determine T. cruzi serostatus using Latent Class Analysis. Results We detected two latent class (LC) of seropositives with low (LC1) and high (LC2) antibody levels. A significantly lower number of seropositives were detected by the Wiener, IgG-TESA-blot, and CDP in LC1 (60.6%, p<0.001, 93.1%, p=0.014, and 84.9%, p=0.002, respectively) as compared to LC2 (100%, 100%, and 98.2%, respectively). LC1 was the main type of seropositives in TcI-predominant areas, representing 65.0% of all seropositives as opposed to 22.8% in TcII/V/VI-predominant areas. The highest sensitivity was observed for the Hemagen (100%, 95% CI: 96.2-100.0), but this test has a low specificity (90.4%, 95% CI: 88.7-91.9). The best balance between positive (90.9%, 95% CI: 83.5-95.1), and negative (99.9%, 95% CI: 99.4-99.9) predictive values was obtained with the Wiener. Conclusion Deficiencies in current FDA-cleared assays were observed. Low antibody levels are the main type of seropositives in individuals from TcI-predominant areas, the most frequent immigrant group in the U.S.

scholarly journals Highly Accurate Chimeric Proteins for the Serological Diagnosis of Chronic Chagas Disease: A Latent Class Analysis

2018 ◽  
Vol 99 (5) ◽  
pp. 1174-1179 ◽  
Author(s):  
Fred Luciano Neves Santos ◽  
Ana Clara Paixão Campos ◽  
Leila Denise Alves Ferreira Amorim ◽  
Edimilson Domingos Silva ◽  
Nilson Ivo Tonin Zanchin ◽  
...  
Keyword(s):  
Latent Class Analysis ◽  
Chagas Disease ◽  
Latent Class ◽  
Serological Diagnosis ◽  
Chimeric Proteins ◽  
Class Analysis ◽  
Chronic Chagas Disease

Latent Class Analysis of Psychosocial and Psychophysiological Risks for Drinking

2009 ◽  
Author(s):  
Tomoko Udo ◽  
Jennifer F. Buckman ◽  
Marsha E. Bates ◽  
Evgeny Vaschillo ◽  
Bronya Vaschillo ◽  
...  
Keyword(s):  
Latent Class Analysis ◽  
Latent Class ◽  
Class Analysis
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