Operational evaluation of Long-Lasting Insecticidal Nets effectiveness on human-vector contact in African urban malaria context
Abstract Background Malaria is still a major public health concern in Côte d’Ivoire despite mass distribution of long-lasting insecticidal nets (LLINs) as a key preventive strategy. This study intended to evaluate the operational effectiveness of LLINs on the level of human-vector contact using one antibody-based biomarker of exposure to Anopheles in urban areas. Methods A cross-sectional study collected socio-demographic data and use of LLINs from 9 neighborhoods of the city of Bouaké (Côte d’Ivoire). Dry blood spots performed in children over 6 months and adults were used to evaluate immunoglobulin G (IgG) responses to the Anopheles gSG6-P1 salivary peptide. Result IgG response levels to the salivary peptide were significantly lower in individuals who declared having “always, n = 270” slept under a LLIN compared to those who had “often, n = 2087” and “never, n = 88” slept under a LLIN (P < 0.0001). IgG response levels to gSG6-P1 between those who declared having “always” and “not always” slept under a LLIN use varied according to the neighborhood, the socio-professional category and the age groups studied. Conclusion The human IgG level to this gSG6-P1 salivary peptide could be a useful tool to evaluate the actual effectiveness of LLINs and help design behavioural change interventions that are crucial for sustaining universal coverage.