Incidence and Impact of Persistent Viremia on SVR Rates in Patients Receiving Direct-Acting Antiviral Therapy

Alicia B Carver; Autumn D Zuckerman; Joshua DeClercq; Leena Choi; Cody A Chastain

doi:10.1093/ofid/ofaa569

Incidence and Impact of Persistent Viremia on SVR Rates in Patients Receiving Direct-Acting Antiviral Therapy

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa569 ◽

2020 ◽

Vol 7 (12) ◽

Author(s):

Alicia B Carver ◽

Autumn D Zuckerman ◽

Joshua DeClercq ◽

Leena Choi ◽

Cody A Chastain

Keyword(s):

Antiviral Therapy ◽

Real World ◽

Sustained Virologic Response ◽

Response Rates ◽

Virologic Response ◽

Direct Acting Antiviral ◽

Rapid Virologic Response ◽

Persistent Viremia ◽

Direct Acting ◽

High Sustained Virologic Response

Abstract Rates of persistent viremia (PV) while on direct-acting antiviral therapy were low (5.7%) in a real-world cohort of 983 patients. High sustained virologic response rates were achieved both in patients with PV (92.9%) and those with rapid virologic response (96.5%), without significant differences.

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Real‐world Australian data reflect very high sustained virologic response at 12 weeks with direct acting antiviral therapy for hepatitis C and suggests highly achievable even in those without an end‐of‐treatment response

Internal Medicine Journal ◽

10.1111/imj.14279 ◽

2019 ◽

Vol 49 (5) ◽

pp. 666-669

Author(s):

James Williams ◽

Nicolas Lucarelli ◽

Amanda Nicoll ◽

John Lubel

Keyword(s):

Hepatitis C ◽

Antiviral Therapy ◽

Real World ◽

Sustained Virologic Response ◽

Virologic Response ◽

Direct Acting Antiviral ◽

End Of Treatment ◽

Direct Acting ◽

High Sustained Virologic Response ◽

Very High

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Faculty Opinions recommendation of High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717948566.793458146 ◽

2012 ◽

Author(s):

Alex Thompson

Keyword(s):

Clinical Trials ◽

Real World ◽

Sustained Virologic Response ◽

Randomized Clinical Trials ◽

Response Rates ◽

Virologic Response ◽

Rapid Virologic Response ◽

High Sustained Virologic Response

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High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials

Hepatology ◽

10.1002/hep.25892 ◽

2012 ◽

Vol 56 (6) ◽

pp. 2039-2050 ◽

Cited By ~ 74

Author(s):

Patrick Marcellin ◽

Hugo Cheinquer ◽

Manuela Curescu ◽

Geoffrey M. Dusheiko ◽

Peter Ferenci ◽

...

Keyword(s):

Clinical Trials ◽

Real World ◽

Sustained Virologic Response ◽

Randomized Clinical Trials ◽

Response Rates ◽

Virologic Response ◽

Rapid Virologic Response ◽

High Sustained Virologic Response

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Faculty Opinions recommendation of High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717948566.793453623 ◽

2012 ◽

Author(s):

Stan Deresinski

Keyword(s):

Clinical Trials ◽

Real World ◽

Sustained Virologic Response ◽

Randomized Clinical Trials ◽

Response Rates ◽

Virologic Response ◽

Rapid Virologic Response ◽

High Sustained Virologic Response

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DI-062 Sustained virologic response rates of new direct acting antiviral agents for HCV

European Journal of Hospital Pharmacy ◽

10.1136/ejhpharm-2016-000875.328 ◽

2016 ◽

Vol 23 (Suppl 1) ◽

pp. A145.2-A146

Author(s):

C Caballero Requejo ◽

M Onteniente Candela ◽

JJ Franco Miguel ◽

M Garcia Coronel ◽

A Trujillano Ruiz ◽

...

Keyword(s):

Sustained Virologic Response ◽

Antiviral Agents ◽

Response Rates ◽

Virologic Response ◽

Direct Acting Antiviral ◽

Direct Acting ◽

Direct Acting Antiviral Agents

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HCV genotype 4, 5 and 6: Distribution of viral subtypes and sustained virologic response rates in clinical trials of approved direct-acting antiviral regimens

Journal of Viral Hepatitis ◽

10.1111/jvh.12896 ◽

2018 ◽

Vol 25 (8) ◽

pp. 969-975 ◽

Cited By ~ 7

Author(s):

S. D. Boyd ◽

P. Harrington ◽

T. E. Komatsu ◽

L. K. Naeger ◽

K. Chan-Tack ◽

...

Keyword(s):

Clinical Trials ◽

Sustained Virologic Response ◽

Response Rates ◽

Virologic Response ◽

Genotype 4 ◽

Hcv Genotype ◽

Direct Acting Antiviral ◽

Direct Acting ◽

Viral Subtypes

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Hepatitis C “true” late relapse beyond 48 weeks of sustained virologic response after direct acting antiviral therapy

Journal of Hepatology ◽

10.1016/j.jhep.2017.01.002 ◽

2017 ◽

Vol 66 (4) ◽

pp. 862-863 ◽

Cited By ~ 9

Author(s):

Thomas Klag ◽

Julia Dietz ◽

Christoph R. Werner ◽

Julia M. Schwarz ◽

Ulrich M. Lauer ◽

...

Keyword(s):

Hepatitis C ◽

Antiviral Therapy ◽

Sustained Virologic Response ◽

Virologic Response ◽

Late Relapse ◽

Direct Acting Antiviral ◽

Direct Acting

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Sustained virologic response with 6 weeks or less of direct‐acting antiviral therapy for chronic hepatitis C: Experience at a veterans affairs healthcare system

Journal of Gastroenterology and Hepatology ◽

10.1111/jgh.14703 ◽

2019 ◽

Vol 34 (12) ◽

pp. 2173-2178

Author(s):

Prajwol Joshi ◽

Amanda Atherton

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Antiviral Therapy ◽

Chronic Hepatitis C ◽

Healthcare System ◽

Sustained Virologic Response ◽

Virologic Response ◽

Veterans Affairs ◽

Direct Acting Antiviral ◽

Direct Acting

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What Are the Benefits of a Sustained Virologic Response to Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection?

Gastroenterology ◽

10.1053/j.gastro.2018.10.033 ◽

2019 ◽

Vol 156 (2) ◽

pp. 446-460.e2 ◽

Cited By ~ 49

Author(s):

George N. Ioannou ◽

Jordan J. Feld

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Antiviral Therapy ◽

Sustained Virologic Response ◽

Virologic Response ◽

Hepatitis C Virus Infection ◽

Direct Acting Antiviral ◽

Direct Acting

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THU-190-Characteristics associated with sustained virologic response in chronic hepatitis C patients who received an abbreviated course of direct-acting antiviral therapy

Journal of Hepatology ◽

10.1016/s0618-8278(19)30465-7 ◽

2019 ◽

Vol 70 (1) ◽

pp. e246

Author(s):

Kirsten Vest ◽

Mei Chang ◽

Troy Kish ◽

Amy Horey ◽

Mitchell Snyder ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Antiviral Therapy ◽

Chronic Hepatitis C ◽

Sustained Virologic Response ◽

Virologic Response ◽

Direct Acting Antiviral ◽

Direct Acting ◽

Chronic Hepatitis C Patients

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