scholarly journals Case Report: Overwhelming Babesia Parasitemia Successfully Treated Promptly With RBC Apheresis and Triple Therapy With Clindamycin, Azithromycin, and Atovaquone

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Yijia Li ◽  
Susan Stanley ◽  
Julian A Villalba ◽  
Sandra Nelson ◽  
Jeffrey Gelfand

Abstract Babesiosis with high-grade parasitemia is life-threatening, especially in asplenic hosts. We report an asplenic patient with parasitemia >50% who was successfully treated with prompt red blood cell apheresis and triple therapy with clindamycin + azithromycin + atovaquone. This regimen may be an alternative to poorly tolerated clindamycin + quinine in severe cases.

2014 ◽  
Vol 25 (4) ◽  
pp. 384-386 ◽  
Author(s):  
Claudia Stöllberger ◽  
Gabriele Krutisch ◽  
Josef Finsterer

2003 ◽  
Vol 17 (5) ◽  
pp. 399-402
Author(s):  
S. Angelides ◽  
M. G. Gibson ◽  
J. Kurtovic ◽  
S. Riordan

Blood ◽  
2012 ◽  
Vol 120 (3) ◽  
pp. 528-537 ◽  
Author(s):  
Karina Yazdanbakhsh ◽  
Russell E. Ware ◽  
France Noizat-Pirenne

Abstract Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk factors associated with alloimmunization with emphasis on possible mechanisms that can trigger delayed hemolytic transfusion reactions in sickle cell disease, and we describe the challenges in transfusion management of these patients, including opportunities and emerging approaches for minimizing this life-threatening complication.


2020 ◽  
Vol 32 (6) ◽  
pp. 908-911
Author(s):  
Rebecca Radisic ◽  
Sean D. Owens ◽  
Charles A. Manire ◽  
Nicole Montgomery ◽  
Doug Mader ◽  
...  

Loggerhead ( Caretta caretta; Cc) and green sea ( Chelonia mydas; Cm) turtles admitted to rehabilitation facilities may require blood transfusions for supportive treatment of disorders resulting in life-threatening anemia, but, considering the unique erythrocyte chemistry of sea turtles, standardized donor red blood cell (RBC) storage protocols have not been established. Prolonged cold storage and the effects of various anticoagulant-preservative solutions have been associated with increased RBC osmotic fragility across a broad range of species. Increased RBC fragility in stored RBC products has been associated with acute transfusion reactions. The osmotic fragility test is used to measure erythrocyte resistance to hemolysis while being exposed to a series of dilutions of a saline solution. We obtained baseline measurements for osmotic fragility in healthy Cc and Cm. Osmotic fragility testing was performed on samples from 10 Cc to 10 Cm. Fifty percent (50%) RBC hemolysis was identified at a mean NaCl concentration of 0.38% in both species. Results of our study will help guide future studies evaluating optimal storage solutions for sea turtle blood products.


2018 ◽  
Vol 46 (1) ◽  
pp. 332-332 ◽  
Author(s):  
Crystal Breighner ◽  
Xavier Fonseca Fuentes ◽  
Mahrukh Rizvi ◽  
Joseph Hyder
Keyword(s):  

2020 ◽  
Vol 23 (2) ◽  
pp. 55-58
Author(s):  
Robert E. Stowers ◽  
Elie M. Richa ◽  
James R. Stubbs ◽  
S. Breanndan Moore

Author(s):  
Maryam Darnahal ◽  
Hamed Azhdari Tehrani ◽  
Mohammad Vaezi ◽  
Shirin Haghighi

Endothelial injury by toxins, drugs, immune complexes leads to activation of coagulation cascade and thrombosis, which result in platelet consumption and red blood cell injury. These thrombotic microangiopathies can potentially injure numerous organs and result in organ dysfunction. In this case, we present the fourth reported patient with thrombotic thrombocytopenic purpura associated with COVID-19.


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