scholarly journals Omadacycline for the Treatment of Mycobacterium abscessus Disease: A Case Series

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Jeffrey C Pearson ◽  
Brandon Dionne ◽  
Aaron Richterman ◽  
Samuel J Vidal ◽  
Zoe Weiss ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Medical Center ◽  
Academic Medical Center ◽  
Case Series ◽  
Mycobacterium Abscessus ◽  
Academic Medical ◽  
The Us ◽  
Culture Positive ◽  
Definitive Role

Abstract Background Omadacycline is an aminomethylcycline antimicrobial approved by the US Food and Drug Administration in 2018 for community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. It has in vitro activity against nontuberculous mycobacteria, including Mycobacterium abscessus complex, but clinical data for this indication are lacking. Methods Omadacycline use was reviewed at an 804-bed academic medical center. Patients were included if they received omadacycline for culture-proven M abscessus disease in 2019. Results Four patients received omadacycline for the treatment of culture-positive M abscessus disease in 2019. Two patients had cutaneous disease, 1 had pulmonary disease, and 1 had osteomyelitis and bacteremia. The patients received omadacycline for a median duration of 166 days (range, 104–227) along with a combination of other antimicrobial agents. Omadacycline-containing regimens were associated with a clinical cure in 3 of 4 patients, with 1 patient improving on ongoing treatment. Omadacycline’s tolerability was acceptable for patients with M abscessus disease, with 1 patient discontinuing therapy in month 6 due to nausea. Conclusions Omadacycline is a novel oral option for the treatment of M abscessus disease, for which safe and effective options are needed. Although this case series is promising, further data are required to determine omadacycline’s definitive role in the treatment of M abscessus disease.

Growth and Management of Repaired Complete Tracheal Rings after Slide Tracheoplasty

2019 ◽  
Vol 161 (1) ◽  
pp. 164-170 ◽  
Author(s):  
Lyndy J. Wilcox ◽  
Claudia Schweiger ◽  
Catherine K. Hart ◽  
Alessandro de Alarcon ◽  
Nithin S. Peddireddy ◽  
...  
Keyword(s):  
Medical Center ◽  
Academic Medical Center ◽  
Balloon Dilation ◽  
Case Series ◽  
Slide Tracheoplasty ◽  
Time Period ◽  
Academic Medical ◽  
Operative Notes ◽  
Over Time

ObjectiveThis study documents the growth and course of repaired complete tracheal rings over time after slide tracheoplasty.Study DesignCase series with review.SettingTertiary pediatric academic medical center.Subjects/MethodsMedical records of pediatric patients with confirmed tracheal rings on bronchoscopy who underwent slide tracheoplasty between January 2001 and December 2015 were reviewed. Patients who had operative notes documenting tracheal sizing over time were included. Exclusion criteria included tracheal stenosis not caused by complete tracheal rings, surgical repair prior to presentation at our institution, or lack of adequate sizing information. The postoperative follow-up was examined and airway growth over time documented.ResultsOf 197 slide tracheoplasties performed during the study time period, 139 were for complete tracheal rings, and 40 of those children met inclusion criteria. The median age at time of surgery was 7 months, and the median initial airway size was 3.9 mm (n = 34). The median growth postoperatively was 1.9 mm over a median follow-up period of 57 months (0.42 mm/year), which is similar to growth rates of unrepaired complete tracheal rings ( P = .53). Children underwent a median of 10 postoperative endoscopies, with time between endoscopies increasing further out from surgery. The most commonly performed adjunctive procedure was balloon dilation.ConclusionsThis is the first study documenting continued growth of repaired complete tracheal rings after slide tracheoplasty. Postoperative endoscopic surveillance ensures adequate growth. Intervals between airway endoscopies can be increased as the child gets older, as the airway increases in size, and as long as symptoms are minimal.

Abstract 1435: Cabozantinib for relapsed neuroblastoma: Case series from one academic medical center

2020 ◽  
Author(s):  
Michael P. Perisa ◽  
Keri Streby ◽  
Mark Ranalli ◽  
Micah A. Skeens ◽  
Nilay Shah
Keyword(s):  
Medical Center ◽  
Academic Medical Center ◽  
Case Series ◽  
Academic Medical

scholarly journals Epidemiology of Hospital-Acquired Urinary Tract–Related Bloodstream Infection at a University Hospital

2011 ◽  
Vol 32 (11) ◽  
pp. 1127-1129 ◽  
Author(s):  
Robert Chang ◽  
M. Todd Greene ◽  
Carol E. Chenoweth ◽  
Latoya Kuhn ◽  
Emily Shuman ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Bloodstream Infection ◽  
Case Fatality Rate ◽  
Medical Center ◽  
Academic Medical Center ◽  
Case Series ◽  
Case Fatality ◽  
University Hospital ◽  
Academic Medical ◽  
Hospital Acquired

Little is known about the epidemiology of nosocomial urinary tract-related bloodstream infection. In a case series from an academic medical center, Enterococcus (28.7%) and Candida (19.6%) species were the predominant microorganisms, which suggests a potential shift from gram-negative microorganisms. A case-fatality rate of 32.8% highlights the severity of this condition.

scholarly journals COVID-19 Related Deaths in an Urban Academic Medical Center in Brooklyn – A Descriptive Case Series

2020 ◽  
Author(s):  
James Andrew McCracken ◽  
Mohamed Nakeshbandi ◽  
Jeffrey Arace ◽  
Wayne J Riley ◽  
Roopali Sharma
Keyword(s):  
New York ◽  
Medical Center ◽  
Academic Medical Center ◽  
Case Series ◽  
Retrospective Chart Review ◽  
Black Population ◽  
International Travel ◽  
Normal Limits ◽  
Academic Medical ◽  
Patients At Risk

Abstract Background Available studies are lacking in analysis of baseline demographics and hospital presentation of patients at risk of expiring due to coronavirus disease 2019 (COVID-19), particularly Black American patients. We conducted a retrospective chart review to determine similarities in demographics and hospital presentation among patients who expired due to COVID-19 at an academic medical center in Brooklyn, New York.Study design and methods This is a retrospective observational study of 200 patients who expired due to complications of COVID-19. Patients were included in this study if they had laboratory-confirmed SARS-CoV-2 infection and expired during their admission. Data were collected on patients who expired between March 17 and April 16, 2020. Results A vast majority of patients were Black Americans (89%) with no history of international travel who had more than one comorbidity (81%), with the most common comorbidities being hypertension (84·5%), diabetes mellitus (57·5%), and obesity (41·5%). Fifty-five percent of our patient population had three or more comorbidities. Among patients with available data, C-reactive protein, lactate dehydrogenase, and ferritin values were elevated above normal limits at admission. Dyspnea was the most common presenting symptom (92·5%). Most (90·5%) presented within the first week of symptoms, with a median time of symptoms prior to expiration being 8·42 days (IQR 5·57 – 12·72). Interpretation Socioeconomic status and healthcare inequalities have greatly affected the Black population of Brooklyn, New York, and these disparities become even more apparent in COVID-19 infection. Patients presenting with numerous comorbidities and elevated inflammatory markers represent a population at high risk of in-hospital mortality.

Characteristics of Postgraduate Physician Assistant Residency/fellowship Programs: A National Survey

2021 ◽  
Author(s):  
Vasco Kidd ◽  
Sarah Vanderlinden ◽  
Roderick Hooker
Keyword(s):  
Physician Assistant ◽  
Medical Center ◽  
Academic Medical Center ◽  
Postgraduate Education ◽  
Physician Assistants ◽  
Teaching Hospitals ◽  
Assigned Reading ◽  
Academic Medical ◽  
Wide Range ◽  
The Us

Abstract Introduction: The development of postgraduate programs for physician assistants (PAs) began in 1973 and by 2020 there were approximately 100 programs spread across a broad range of medical and surgical disciplines. An assessment of these programs was undertaken. Method: A non-experimental, descriptive research study was designed to obtain information on the characteristics of PA postgraduate education programs in the US. The source of information was from surveyed members of the Association of Postgraduate Physician Assistant Programs. Questions were drawn from consensus discussions. Programs that were operational in 2020 were eligible to participate. Results: Seventy-two programs were invited to the survey and 34 replied. They are geographically distributed across the US in 13 states. The respondents represent a wide range of medicine: surgery, emergency medicine, critical care, orthopaedics, hospitalist, psychiatry, oncology, primary care, pediatrics, and cardiology. Most programs are associated with an academic medical center. The curriculum includes bedside teaching, lectures, mentorship, assigned reading, procedures, simulation, and conferences. The PA fellow serves as house officer alongside physician residents and fellows. An average program length is 12 months and awards a certificate. Stipends for PA fellows are $50,000-80,000 (2020 dollars) and benefits include paid time off, health and liability insurance. About half of the programs bill for the services rendered by the PA. Over 90% of graduates are employed within two months of fellowship completion. Conclusion: A trend is underway in American medicine to include PAs in postgraduate education. PA fellowships occur across a broad spectrum of medical and surgical areas, as well as diverse institutions and organizations overseeing the programs. Most are in academic medical centers or teaching hospitals. This study expands information on PA fellowships and their operation.

scholarly journals Are USMLE Scores Valid Measures for Chief Resident Selection?

2020 ◽  
Vol 12 (4) ◽  
pp. 441-446
Author(s):  
Elaine R. Cohen ◽  
Joshua L. Goldstein ◽  
Clara J. Schroedl ◽  
Nancy Parlapiano ◽  
William C. McGaghie ◽  
...  
Keyword(s):  
Medical Center ◽  
Academic Medical Center ◽  
Chief Resident ◽  
Academic Medical ◽  
The Us ◽  
Residency Selection ◽  
P 16 ◽  
Usmle Step 1 ◽  
Usmle Step ◽  
Resident Selection

ABSTRACT Background The US Medical Licensing Examination (USMLE) Step 1 and Step 2 scores are often used to inform a variety of secondary medical career decisions, such as residency selection, despite the lack of validity evidence supporting their use in these contexts. Objective We compared USMLE scores between non–chief residents (non-CRs) and chief residents (CRs), selected based on performance during training, at a US academic medical center that sponsors a variety of graduate medical education programs. Methods This was a retrospective cohort study of residents' USMLE Step 1 and Step 2 Clinical Knowledge (CK) scores from 2015 to 2020. The authors used archived data to compare USMLE Step 1 and Step 2 CK scores between non-CR residents in each of the eligible programs and their CRs during the 6-year study period. Results Thirteen programs enrolled a total of 1334 non-CRs and 211 CRs over the study period. There were no significant differences overall between non-CRs and CRs average USMLE Step 1 (239.81 ± 14.35 versus 240.86 ± 14.31; P = .32) or Step 2 scores (251.06 ± 13.80 versus 252.51 ± 14.21; P = .16). Conclusions There was no link between USMLE Step 1 and Step 2 CK scores and CR selection across multiple clinical specialties over a 6-year period. Reliance on USMLE Step 1 and 2 scores to predict success in residency as measured by CR selection is not recommended.

Implementation of a Prolonged Infusion Guideline for Time-Dependent Antimicrobial Agents at a Tertiary Academic Medical Center

2016 ◽  
Vol 23 (6) ◽  
pp. e1768-e1773 ◽  
Author(s):  
Benjamin Hohlfelder ◽  
David W. Kubiak ◽  
Jeremy R. Degrado ◽  
David P. Reardon ◽  
Paul M. Szumita
Keyword(s):  
Antimicrobial Agents ◽  
Medical Center ◽  
Academic Medical Center ◽  
Time Dependent ◽  
Prolonged Infusion ◽  
Academic Medical

scholarly journals Disorders Involving a Persistent Craniopharyngeal Canal: A Case Series

2019 ◽  
Vol 81 (05) ◽  
pp. 562-566
Author(s):  
Seerat K. Poonia ◽  
Diego Cazzador ◽  
Adam C. Kaufman ◽  
Michael A. Kohanski ◽  
Edward C. Kuan ◽  
...  
Keyword(s):  
Congenital Anomaly ◽  
Surgical Repair ◽  
Medical Center ◽  
Academic Medical Center ◽  
Case Series ◽  
Cerebrospinal Fluid Leak ◽  
Preoperative Imaging ◽  
Academic Medical ◽  
Craniopharyngeal Canal ◽  
Transnasal Endoscopic Repair

Objectives A persistent craniopharyngeal canal (CPC) is a rare embryologic remnant that presents as a well-corticated defect of the midline sphenoid body extending from the sellar floor to the nasopharynx. Our case series aims to describe three unique presentations of this congenital anomaly and their subsequent management.Design Retrospective review.Setting Tertiary academic medical center.Participants Patients who underwent endoscopic transnasal surgical repair of a CPC lesion.Main Outcome Measures Resolution of symptoms and surgical outcomes.Results A total of three patients were identified. The clinical presentation varied, however, all cases prompted further imaging which demonstrated a persistent CPC and associated pathologic lesion. The presentation of a persistent CPC with nasal obstruction and subsequent iatrogenic cerebrospinal fluid leak as in Case 1 demonstrates the importance of imaging in this work-up. Cases 2 and 3 in the series were representative of the larger subset of patients in the literature who present with the defect incidentally but still warrant surgical management. Nonetheless, a standard approach to diagnosis with preoperative imaging and subsequent transnasal endoscopic repair of the skull base defect was undertaken.Conclusion The persistent CPC is a rare congenital anomaly associated with diverse pathology and careful review of preoperative radiology is critical to the management. When warranted, subsequent surgical repair and reconstruction is associated with excellent postoperative outcomes.

Validation of PLASMIC score: an academic medical center case series (2012‐present)

Transfusion ◽  
2020 ◽  
Vol 60 (7) ◽  
pp. 1536-1543 ◽  
Author(s):  
Harrison Moosavi ◽  
Yamin Ma ◽  
Maureen J. Miller ◽  
Alexander Duncan
Keyword(s):  
Medical Center ◽  
Academic Medical Center ◽  
Case Series ◽  
Academic Medical
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