scholarly journals Parvovirus B19-Infected Tubulointerstitial Nephritis in Hereditary Spherocytosis

2020 ◽  
Vol 7 (8) ◽  
Author(s):  
Kei Nishiyama ◽  
Yuka Watanabe ◽  
Masataka Ishimura ◽  
Kenichi Tetsuhara ◽  
Takashi Imai ◽  
...  
Keyword(s):  
Kidney Biopsy ◽  
Hereditary Spherocytosis ◽  
Tubulointerstitial Nephritis ◽  
Parvovirus B19 ◽  
Kidney Injury ◽  
Histopathological Diagnosis ◽  
Tubular Epithelial Cells ◽  
Continuous Hemodiafiltration ◽  
Aplastic Crisis ◽  
Virus Capsid Protein

Abstract Background Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis. Methods Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure. Results A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells. Conclusions Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.

Tubulitis in a patient treated with nivolumab: Case report and literature review

2018 ◽  
Vol 2 (2-3) ◽  
pp. 107-112
Author(s):  
Viral Vakil ◽  
Mark Birkenbach ◽  
Katti Woerner ◽  
Lihong Bu
Keyword(s):  
Acute Kidney Injury ◽  
Immune Checkpoint Inhibitors ◽  
Kidney Biopsy ◽  
Tubulointerstitial Nephritis ◽  
Checkpoint Inhibitors ◽  
Kidney Injury ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Metastatic Urothelial Carcinoma ◽  
Programmed Death 1

Kidney injury associated with use of immune checkpoint inhibitors that target the programmed death-1 molecule commonly manifests as acute tubulointerstitial nephritis on kidney biopsy. We present a case of a 66-year-old man who developed acute kidney injury at 6 months after initiation of treatment with anti-programmed death-1 antibody, nivolumab, for treatment of metastatic urothelial carcinoma. A renal biopsy showed focal moderate-to-severe lymphocytic tubulitis with minimal interstitial inflammation. Programmed death ligand-1 immunopositivity was detected only in tubules exhibiting lymphocytic tubulitis. The patient’s renal function improved to baseline with conservative management consisting of discontinuation of nivolumab followed by prednisone treatment.

scholarly journals Parvovirus B19 infection and kidney injury: report of 4 cases and analysis of immunization and viremia in an adult cohort of 100 patients undergoing a kidney biopsy.

2020 ◽  
Author(s):  
Maëlis Kauffmann ◽  
Mickaël Bobot ◽  
Laurent Daniel ◽  
Julia Torrents ◽  
Yannick Knefati ◽  
...  
Keyword(s):  
Primary Infection ◽  
Kidney Biopsy ◽  
Kidney Diseases ◽  
Parvovirus B19 ◽  
Kidney Injury ◽  
Etiologic Agent ◽  
Additional Patient ◽  
Viral Dna ◽  
Systematic Screening ◽  
Tubular Necrosis

Abstract BACKGROUND: The seroprevalence of human Parvovirus B19 (PVB19) is 70-85 % in adults worldwide. PVB19 is the etiologic agent of the fifth disease, is a cause of aplastic anemia, and can be associated with kidney injury. We aimed to describe the cases of 4 patients with kidney injury related to PVB19 primary infection, and to evaluate the seroprevalence of PVB19 and the incidence of PVB19 primary infection in patients undergoing a native kidney biopsy.METHODS: Cases of PVB19 infection with kidney injury were reviewed from the archives of the department of Nephrology. A systematic screening of anti-PVB19 IgG and IgM antibodies and viral DNA was performed in sera from 100 consecutive patients with a kidney biopsy in 2017-2018.RESULTS: The 4 patients with PVB19 infection-associated kidney disease displayed: one lupus-like glomerulonephritis (GN) without lupus auto-antibodies, one minimal change disease with tubular necrosis, one secondary hemolytic and uremic syndrome and one membrano-proliferative GN. In the 100 patients biopsied, 67 had elevated anti-PVB19 IgG, among whom 8 had elevated IgM, without circulating viral DNA, without any particular renal pathological pattern. One additional patient showed a seroconversion at the time of kidney biopsy, which revealed a class V lupus nephritis. CONCLUSION: PVB19 primary infection can be associated with different kidney diseases. The seroprevalence of PVB19 among patients with a kidney biopsy is similar to the overall population, and primary infection is rarely documented (1%) after systematic screening. Whether PV19 is nephrotoxic, or triggers renal endothelial injury and immune activation, remains to be elucidated.

scholarly journals An Adult with Aplastic Crisis induced by Human Parvovirus B19 as an Initial Presentation of Hereditary Spherocytosis

2005 ◽  
Vol 20 (1) ◽  
pp. 96 ◽  
Author(s):  
Sook Eui Oh ◽  
Jung Han Kim ◽  
Chi Hun Choi ◽  
Kwang Hyuk Park ◽  
Joo Young Jung ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Initial Presentation ◽  
Human Parvovirus B19 ◽  
Aplastic Crisis

scholarly journals Clinical Case of Aplastic Crisis Associated with Extramedullary Hematopoiesis in an Adult With Hereditary Spherocytosis and Parvovirus B19 Infection

2015 ◽  
Vol 34 (1-2) ◽  
pp. 39-44
Author(s):  
Andreea Jercan ◽  
Rusu Munteanu Gina ◽  
Camelia Dobrea ◽  
Daniel Coriu ◽  
Aurelia Tatic
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Extramedullary Hematopoiesis ◽  
Blood Film ◽  
Red Cell Membrane ◽  
Infectious Episode ◽  
Indirect Bilirubin ◽  
Aplastic Crisis ◽  
Chronic Hemolysis ◽  
Parvovirus B19 Infection

Abstract Hereditary spherocytosis is an inherited hemolytic anemia due to red cell membrane defects, characterised by chronic hemolysis with different severity degrees, splenomegaly and microspherocytosis on the peripheral blood film. Among the possible complications in these patients are aplastic crisis and extramedullary hematopoiesis. In this article we present the case of a 42 years old man with hereditary spherocytosis diagnosed during childhood (average haemoglobin (Hb) value of 11-12 g/dl), which presented with worsening anemia, fever, chills, bone and muscle pain. The evolution was with accentuation of anemia (Hb 4.2 g/dl), decease of reticulocyte number (Ret 0,8%) and bilirubin (indirect bilirubin 2.7 g/dl). ParvovirusB19 DNA was 100.000.000 copies/ml. A computer tomography (CT)scan was performed and showed extramedullary hematopoiesis areas situated paravertebraly in the inferior thorax and hepatosplenomegaly. The infectious episode was self-limited and improved with substitution treatment.

scholarly journals Transient aplastic crisis triggered by parvovirus B19 in a family with hereditary spherocytosis

IDCases ◽  
2020 ◽  
Vol 21 ◽  
pp. e00802
Author(s):  
Nicolas Cilla ◽  
Léa Domitien ◽  
Neila Arrada ◽  
Delphine Chiffre ◽  
Perrine Mahe ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Aplastic Crisis ◽  
Transient Aplastic Crisis

scholarly journals Acute kidney injury during parvovirus B19-induced transient aplastic crisis in sickle cell disease

2018 ◽  
Vol 93 (8) ◽  
pp. E198-E200 ◽  
Author(s):  
Jamie Oakley ◽  
Rima Zahr ◽  
Inmaculada Aban ◽  
Varsha Kulkarni ◽  
Rakesh P. Patel ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Kidney Injury ◽  
Cell Disease ◽  
Aplastic Crisis ◽  
Transient Aplastic Crisis

scholarly journals Reversal of Gastric Bypass Resolves Hyperoxaluria and Improves Oxalate Nephropathy Secondary to Roux-en-Y Gastric Bypass

2016 ◽  
Vol 6 (3) ◽  
pp. 114-119 ◽  
Author(s):  
Varun Agrawal ◽  
Jonathan B. Wilfong ◽  
Christopher E. Rich ◽  
Pamela C. Gibson
Keyword(s):  
Gastric Bypass ◽  
Kidney Biopsy ◽  
Tubulointerstitial Nephritis ◽  
Gastrointestinal Symptoms ◽  
Kidney Injury ◽  
Urine Dipstick ◽  
Limited Efficacy ◽  
Risk Of Progression ◽  
Urine Oxalate ◽  
Oxalate Nephropathy

Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) increases the risk for kidney injury. Medical therapies for hyperoxaluria have limited efficacy. A 65-year-old female was evaluated for acute kidney injury [AKI, serum creatinine (Cr) 2.1 mg/dl, baseline Cr 1.0 mg/dl]. She did not have any urinary or gastrointestinal symptoms or exposure to nephrotoxic agents. Sixteen months prior to this evaluation, she underwent RYGB for morbid obesity. Her examination was unremarkable for hypertension or edema and there was no protein or blood on urine dipstick. Kidney biopsy revealed acute tubulointerstitial nephritis with oxalate crystals in tubules. The concurrent finding of severe hyperoxaluria (urine oxalate 150 mg/day) confirmed the diagnosis of oxalate nephropathy. Despite medical management of hyperoxaluria, her AKI worsened. Laparoscopic reversal of RYGB was performed and within 1 month, her hyperoxaluria resolved (urine oxalate 20 mg/day) and AKI improved (Cr 1.7 mg/dl). Surgical reversal of RYGB may be considered in patients with oxalate nephropathy at high risk of progression who fail medical therapy. Physicians need to be aware of the possibility of oxalate nephropathy after RYGB and promptly treat the hyperoxaluria to halt further kidney damage.

scholarly journals Acute tubulointerstitial nephritis due to the use of rifampicin. Case report

Case reports ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. 44-51
Author(s):  
Juan Camilo Motta ◽  
Camilo Andrés Rodríguez ◽  
Camilo Cortes ◽  
Jaime Escobar
Keyword(s):  
Acute Kidney Injury ◽  
Case Report ◽  
Side Effects ◽  
Pulmonary Tuberculosis ◽  
Fanconi Syndrome ◽  
Kidney Biopsy ◽  
Tubulointerstitial Nephritis ◽  
Kidney Injury ◽  
History Of ◽  
Or History

Introduction: Rifampin is a cornerstone for the first phase of the treatment of pulmonary tuberculosis. This report presents the case of a patient with allergic tubulointerstitial nephritis (ATIN) due to rifampin, situation that has not been reported in Colombia.Case presentation: A male patient with a history of pulmonary tuberculosis treated with rifampin developed acute kidney injury. On admission, no evidence of abnormalities or history to explain the injury was found, but he did present tubular acidosis and associated Fanconi syndrome. The kidney injury was temporarily consistent with rifampicin use, and a kidney biopsy confirmed ATIN. The drug was suspended, resulting in improved kidney function.Discussion: ATIN as a side effect of rifampin is a scarcely reported disease. The risk of developing this condition should be considered when starting and restarting treatments with this medication.Conclusion: ATIN is one of the side effects of tuberculosis treatment. Albeit rare, it should be considered when starting tuberculosis medications.

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