scholarly journals Targeting the postpartum period to promote weight loss: a systematic review and meta-analysis

2018 ◽  
Vol 76 (8) ◽  
pp. 639-654 ◽  
Author(s):  
Jodie M Dodd ◽  
Andrea R Deussen ◽  
Cecelia M O’Brien ◽  
Danielle A J M Schoenaker ◽  
Amanda Poprzeczny ◽  
...  
2015 ◽  
Vol 17 (11) ◽  
pp. e253 ◽  
Author(s):  
Gemma Flores Mateo ◽  
Esther Granado-Font ◽  
Carme Ferré-Grau ◽  
Xavier Montaña-Carreras

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1671-1671
Author(s):  
Jéssica Polet ◽  
Flávia Silva ◽  
Taiana dos Santos ◽  
Julia Bregolin ◽  
Vivian Luft ◽  
...  

Abstract Objectives To evaluate the effect of lifestyle change programs on weight-loss and its maintenance in obese individuals. The trial sequential analysis (TSA) was applied to determine whether the currently available evidence is sufficient. Methods The PubMed, EMBASE and Lilacs databases were searched for randomized clinical trials published before May of 2018. Data were pooled using an inverse-variance random-effects meta-analysis and expressed as weighted mean differences (WMD) with 95% confidence intervals (CI). Heterogeneity was quantified and explored using subgroup analyses. Results Eleven trials (12 publications, 1416 participants) were considered eligible to be included in this meta-analysis. Caloric restriction was effective to promote weight-loss at 12 months [WMD − 3.79 kg (95%CI − 4.78 to − 2.79), I² = 87.5%] and 24 months [WMD − 6.20 kg (95%CI − 10.81 to − 1.59), I² = 71.2%] and TSA showed convincing evidence of an effect. At 36 months, there were no differences in body weight change [−2.06 kg (95%CI − 7.00 to 2.89), I² = 0.0%] and the meta-analysis included less patients than the required information size according to TSA. Subgroup analyses suggest improved weight-loss for caloric restrictions that are greater than 501 Kcal, Dietitian as the interventionist, intensity of intervention twice a month and dropout rates of < 20%. Conclusions For obesity management in clinical practice, caloric restriction is effective to promote weight-loss for up to two years, preferably with a caloric deficit that is greater than 501 Kcal, if performed by registered Dietitian and if associated with a behavioral component and at least twice-monthly contact with a health team. For weight-loss maintenance greater than three years, large-scale trials are required to support these findings. Funding Sources This systematic review was supported by Fundo de Incentivo à Pesquisa e Eventos (FIPE) from Hospital de Clínicas de Porto Alegre. JPP was recipient of scholarships from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).


2016 ◽  
Vol 10 (3) ◽  
pp. 358-372 ◽  
Author(s):  
Jason C. H. Tang ◽  
Charles Abraham ◽  
Colin J. Greaves ◽  
Vasilis Nikolaou

BMJ ◽  
2021 ◽  
pp. m4743
Author(s):  
Joshua Z Goldenberg ◽  
Andrew Day ◽  
Grant D Brinkworth ◽  
Junko Sato ◽  
Satoru Yamada ◽  
...  

Abstract Objective To determine the efficacy and safety of low carbohydrate diets (LCDs) and very low carbohydrate diets (VLCDs) for people with type 2 diabetes. Design Systematic review and meta-analysis. Data sources Searches of CENTRAL, Medline, Embase, CINAHL, CAB, and grey literature sources from inception to 25 August 2020. Study selection Randomized clinical trials evaluating LCDs (<130 g/day or <26% of a 2000 kcal/day diet) and VLCDs (<10% calories from carbohydrates) for at least 12 weeks in adults with type 2 diabetes were eligible. Data extraction Primary outcomes were remission of diabetes (HbA 1c <6.5% or fasting glucose <7.0 mmol/L, with or without the use of diabetes medication), weight loss, HbA 1c , fasting glucose, and adverse events. Secondary outcomes included health related quality of life and biochemical laboratory data. All articles and outcomes were independently screened, extracted, and assessed for risk of bias and GRADE certainty of evidence at six and 12 month follow-up. Risk estimates and 95% confidence intervals were calculated using random effects meta-analysis. Outcomes were assessed according to a priori determined minimal important differences to determine clinical importance, and heterogeneity was investigated on the basis of risk of bias and seven a priori subgroups. Any subgroup effects with a statistically significant test of interaction were subjected to a five point credibility checklist. Results Searches identified 14 759 citations yielding 23 trials (1357 participants), and 40.6% of outcomes were judged to be at low risk of bias. At six months, compared with control diets, LCDs achieved higher rates of diabetes remission (defined as HbA 1c <6.5%) (76/133 (57%) v 41/131 (31%); risk difference 0.32, 95% confidence interval 0.17 to 0.47; 8 studies, n=264, I 2 =58%). Conversely, smaller, non-significant effect sizes occurred when a remission definition of HbA 1c <6.5% without medication was used. Subgroup assessments determined as meeting credibility criteria indicated that remission with LCDs markedly decreased in studies that included patients using insulin. At 12 months, data on remission were sparse, ranging from a small effect to a trivial increased risk of diabetes. Large clinically important improvements were seen in weight loss, triglycerides, and insulin sensitivity at six months, which diminished at 12 months. On the basis of subgroup assessments deemed credible, VLCDs were less effective than less restrictive LCDs for weight loss at six months. However, this effect was explained by diet adherence. That is, among highly adherent patients on VLCDs, a clinically important reduction in weight was seen compared with studies with less adherent patients on VLCDs. Participants experienced no significant difference in quality of life at six months but did experience clinically important, but not statistically significant, worsening of quality of life and low density lipoprotein cholesterol at 12 months. Otherwise, no significant or clinically important between group differences were found in terms of adverse events or blood lipids at six and 12 months. Conclusions On the basis of moderate to low certainty evidence, patients adhering to an LCD for six months may experience remission of diabetes without adverse consequences. Limitations include continued debate around what constitutes remission of diabetes, as well as the efficacy, safety, and dietary satisfaction of longer term LCDs. Systematic review registration PROSPERO CRD42020161795.


Obesity Facts ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 222-245
Author(s):  
Giovanna Muscogiuri ◽  
Marwan El Ghoch ◽  
Annamaria Colao ◽  
Maria Hassapidou ◽  
Volkan Yumuk ◽  
...  

<b><i>Background:</i></b> The very low-calorie ketogenic diet (VLCKD) has been recently proposed as an appealing nutritional strategy for obesity management. The VLCKD is characterized by a low carbohydrate content (&#x3c;50 g/day), 1–1.5 g of protein/kg of ideal body weight, 15–30 g of fat/day, and a daily intake of about 500–800 calories. <b><i>Objectives:</i></b> The aim of the current document is to suggest a common protocol for VLCKD and to summarize the existing literature on its efficacy in weight management and weight-related comorbidities, as well as the possible side effects. <b><i>Methods:</i></b> This document has been prepared in adherence with Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Literature searches, study selection, methodology development, and quality appraisal were performed independently by 2 authors and the data were collated by means of a meta-analysis and narrative synthesis. <b><i>Results:</i></b> Of the 645 articles retrieved, 15 studies met the inclusion criteria and were reviewed, revealing 4 main findings. First, the VLCKD was shown to result in a significant weight loss in the short, intermediate, and long terms and improvement in body composition parameters as well as glycemic and lipid profiles. Second, when compared with other weight loss interventions of the same duration, the VLCKD showed a major effect on reduction of body weight, fat mass, waist circumference, total cholesterol and triglyceridemia as well as improved insulin resistance. Third, although the VLCKD also resulted in a significant reduction of glycemia, HbA1c, and LDL cholesterol, these changes were similar to those obtained with other weight loss interventions. Finally, the VLCKD can be considered a safe nutritional approach under a health professional’s supervision since the most common side effects are usually clinically mild and easily to manage and recovery is often spontaneous. <b><i>Conclusions:</i></b> The VLCKD can be recommended as an effective dietary treatment for individuals with obesity after considering potential contra-indications and keeping in mind that any dietary treatment has to be personalized. <b><i>Prospero Registry:</i></b> The assessment of the efficacy of VLCKD on body weight, body composition, glycemic and lipid parameters in overweight and obese subjects: a meta-analysis (CRD42020205189).


2017 ◽  
Vol 19 (2) ◽  
pp. 164-177 ◽  
Author(s):  
K. Carrière ◽  
B. Khoury ◽  
M. M. Günak ◽  
B. Knäuper

2007 ◽  
Vol 107 (10) ◽  
pp. 1755-1767 ◽  
Author(s):  
Marion J. Franz ◽  
Jeffrey J. VanWormer ◽  
A. Lauren Crain ◽  
Jackie L. Boucher ◽  
Trina Histon ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document