Emerging role of alpha-lipoic acid in the prevention and treatment of bone loss

2015 ◽  
Vol 73 (2) ◽  
pp. 116-125 ◽  
Author(s):  
J. L. Roberts ◽  
R. Moreau
Keyword(s):  
Bone Loss ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Prevention And Treatment

Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2 O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats

2015 ◽  
Vol 230 (9) ◽  
pp. 2184-2201 ◽  
Author(s):  
Chao Fu ◽  
Dong Xu ◽  
Chang-Yuan Wang ◽  
Yue Jin ◽  
Qi Liu ◽  
...  
Keyword(s):  
Bone Loss ◽  
Lipoic Acid ◽  
Ovariectomized Rats ◽  
Alpha Lipoic Acid

scholarly journals The role of oxidative stress and effect of alpha-lipoic acid in reexpansion pulmonary edema – an experimental study

2010 ◽  
Vol 6 ◽  
pp. 848-853 ◽  
Author(s):  
Seyfettin Gumus ◽  
Orhan Yucel ◽  
Mehmet Gamsizkan ◽  
Ayse Eken ◽  
Omer Deniz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Experimental Study ◽  
Pulmonary Edema ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Reexpansion Pulmonary Edema

scholarly journals Diabetic polyneuropathy: diagnosis, prevention, and treatment

2020 ◽  
Vol 12 (4) ◽  
pp. 113-118
Author(s):  
V. A. Golovacheva ◽  
I. A. Strokov
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Trials ◽  
Nervous System ◽  
Lipoic Acid ◽  
Diabetic Polyneuropathy ◽  
Patient Treatment ◽  
Alpha Lipoic Acid ◽  
Sensorimotor Polyneuropathy ◽  
Chronic Hyperglycemia ◽  
Prevention And Treatment

The most common form of peripheral nervous system damage in diabetes mellitus is distal symmetric sensorimotor polyneuropathy (DSSMPN). Chronic hyperglycemia, dyslipidemia, and impaired microcirculation are considered to be the key mechanisms for the development of DSSMPN, but its pathogenesis is still unclear and continues to be studied. The paper analyzes the issues of diagnosis of DSSMPN and the effective principles of patient treatment. It also discusses the use of alpha-lipoic acid (ALA) as a drug for the pathogenetic treatment of DSSMPN and describes the results of clinical trials of its treatment with ALA preparations.

Potential role of lipoic acid as a chelator in prevention and treatment of gadolinium brain retention

2018 ◽  
Vol 114 ◽  
pp. 29
Author(s):  
Ashkan Heshmatzadeh Behzadi ◽  
Ajay Gupta ◽  
Martin R. Prince
Keyword(s):  
Lipoic Acid ◽  
Potential Role ◽  
Prevention And Treatment

scholarly journals The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

Biology ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 239
Author(s):  
Fatma M. Ghoneim ◽  
Hani Alrefai ◽  
Ayman Z. Elsamanoudy ◽  
Salwa M. Abo El-khair ◽  
Hanaa A. Khalaf
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Lipoic Acid ◽  
Caspase 3 ◽  
Protective Role ◽  
Alpha Lipoic Acid ◽  
Group Iii ◽  
Rat Offspring ◽  
Group I

Background: Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) is a natural compound inducing endogenous antioxidant production. Our study aimed to investigate the effect of prenatal administration of VPA on the pancreas of rat offspring and assess the potential protective role of ALA co-administration during pregnancy. Methods: Twenty-eight pregnant female albino rats were divided into four groups: group I (negative control), group II (positive control, ALA treated), group III (VPA-treated), and group IV (VPA-ALA-treated). The pancreases of the rat offspring were removed at the fourth week postpartum and prepared for histological, immune-histochemical, morphometric, molecular, and oxidative stress marker studies. Results: In group III, there were pyknotic nuclei, vacuolated cytoplasm with ballooning of acinar, α, and β cells of the pancreas. Ultrastructural degeneration of cytoplasmic organelles was detected. Additionally, there was a significant increase in oxidative stress, a decrease in insulin-positive cell percentage, and an increase in glucagon positive cells in comparison to control groups. Moreover, VPA increased the gene expression of an apoptotic marker, caspase-3, with a decrease in anti-apoptotic Bcl2 and nuclear factor erythroid 2-related factor 2 (Nrf2) transcriptional factor. Conversely, ALA improved oxidative stress and apoptosis in group VI, and a consequent improvement of the histological and ultrastructure picture was detected. Conclusion: ALA co-administration with VPA significantly improved the oxidative stress condition, histological and morphometric picture of the pancreas, and restored normal expression of related genes, including Nrf2, caspase-3, and Bcl-2. Administration of α-lipoic acid has a protective effect against VPA-induced pancreatic oxidative damage via its cytoprotective antioxidant effect.

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